2024 No. 7

Vol.40 No.7 (285 in total) Jul. 2024

Theme Issue: Advances in the Treatment of Metastatic Liver Cancer

Executive Chief Editor: CHEN Jinhong

Huashan Hospital, Fudan University

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Editorial

Treatment of metastatic liver cancer： Current status and future perspectives

Xiangyu WANG, Jinhong CHEN

2024, 40(7): 1289-1294. DOI: 10.12449/JCH240701

Abstract(1579)

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The liver is a common metastatic site of malignant tumors， and liver metastasis is also the leading cause of death due to metastatic tumors. Metastatic liver cancer has high heterogeneity， and there has been slow progress in the treatment of metastatic liver cancer for a long time. In recent years， ...

Expert Forum

Treatment strategy of non-radical surgical resection for colorectal cancer liver metastases

Rui ZHANG, Jinhong CHEN

2024, 40(7): 1295-1300. DOI: 10.12449/JCH240702

Abstract(1118)

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Effective treatment of colorectal cancer liver metastases is crucial for improving the survival rate and quality of life of patients with colorectal cancer. With the application of systemic chemotherapy， there have been increases in the conversion rate and surgical resection rate of patients with co...

Surgical intervention strategies for liver metastasis of neuroendocrine tumors

Junqing WANG, Yongjun CHEN

2024, 40(7): 1301-1306. DOI: 10.12449/JCH240703

Abstract(1058)

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Neuroendocrine tumors are a group of rare tumor diseases that can occur in various visceral organs of the human body and exhibit significant tumor heterogeneity， and they often lead to secondary tumors mostly involving the liver and carcinoid syndrome. Liver metastasis is an important cause of treat...

Research advances in the treatment of cervical cancer with liver metastasis

Shangdan XIE, Qunchao HU, Haiyan ZHU

2024, 40(7): 1307-1311. DOI: 10.12449/JCH240704

Abstract(968)

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Though liver metastasis of cervical cancer has a relatively low incidence rate， it is often accompanied by metastasis in other sites and thus has a poor prognosis. For the patients with liver metastasis of cervical cancer， it is necessary to formulate individualized treatment regimens based on vario...

Guideline

Chinese guideline for diagnosis and treatment of autoimmune pancreatitis （Shanghai， 2023）

National Clinical Research Center for Digestive Diseases （Shanghai）； National Key Laboratory of Immunity and Inflammation；Professional Committee of Pancreatic Disease， Chinese Medical Doctor Association； Pancreas Study Group， Society of Gastroenterology，Chinese Medical Association； Editorial Board of Chinese Journal of Pancreatology

2024, 40(7): 1312-1320. DOI: 10.12449/JCH240705

Abstract(1454)

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Autoimmune pancreatitis （AIP） is an immune⁃mediated， special type of chronic pancreatitis， which can involve multiple organs. The clinical manifestation of AIP is complex and varied， making the diagnosis and treatment challenging. With reference to the latest guidelines and studies from both domesti...

An excerpt of the American College of Gastroenterology clinical guideline on alcohol-associated liver disease in 2024

Furong SUN, Bingyuan WANG

2024, 40(7): 1321-1323. DOI: 10.12449/JCH240706

Abstract(1118)

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The American College of Gastroenterology published the clinical guideline on alcohol-associated liver disease （ALD） in January 2024 in American Journal of Gastroenterology. This guideline elaborates on the epidemiology and disease burden of ALD and alcohol use disorder， the risk factors for ALD， the...

Guideline Interpretation

Interpretation of guidelines for the diagnosis and treatment of primary liver cancer （2024 edition）

Zhao LI, Jiye ZHU

2024, 40(7): 1324-1327. DOI: 10.12449/JCH240707

Abstract(2177)

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In June 2017， National Health Commission of the People’s Republic of China released Guidelines for the diagnosis and treatment of primary liver cancer （2017 edition）， which provided important recommendations for the diagnosis， staging， and treatment of liver cancer. Since then， high-level evidence i...

Viral Hepatitis

Establishment of a noninvasive predictive model for antiviral therapy in patients with chronic hepatitis B virus infection and an age of ≤30 years

Changxiang LAI, Qingrong TANG, Xiulian ZHANG, Qiyuan TANG, Zhiyu LI, Xuan ZHOU, Wenjie XIAN, Ruikun CHEN, Xiaojuan WU, Fang WANG

2024, 40(7): 1328-1333. DOI: 10.12449/JCH240708

Abstract(741)

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Objective To predict whether antiviral therapy is required in patients with chronic hepatitis B virus （HBV） infection and an age of ≤30 years by establishing a noninvasive model， and to investigate the diagnostic value of this model. Methods A retrospective analysis was performed for the clinical da...

Incidence rate of low-level viremia and related influencing factors in treatment-experienced chronic hepatitis B patients： A Meta-analysis

Lu XIE, Yanan LIU, Guangwei LIU, Pengyu LI, Xinning HU, Qiujia KANG, Huijun GUO

2024, 40(7): 1334-1342. DOI: 10.12449/JCH240709

Abstract(726)

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Objective To systematically evaluate the incidence rate of low-level viremia （LLV） in chronic hepatitis B （CHB） patients and related influencing factors， and to provide evidence-based medicine evidence for effective intervention and prevention of LLV in clinical practice. Methods This study was cond...

Virological features of chronic hepatitis B patients with metabolic associated fatty liver disease： A stratified analysis

Lingna LYU, Qi LI, Wenxia MA, Huiguo DING, Hui LIU

2024, 40(7): 1343-1348. DOI: 10.12449/JCH240710

Abstract(342)

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Objective To investigate the virological features of patients with chronic hepatitis B （CHB） and metabolic associated fatty liver disease （MAFLD） through a stratified analysis. Methods A retrospective analysis was performed for 131 patients with CHB and MAFLD and 168 patients with CHB alone who unde...

Fatty Liver Disease

Expression of serum 25-hydroxyvitamin D and its clinical significance in patients with nonalcoholic fatty liver disease and obesity

Linlin WU, Fan ZHANG

2024, 40(7): 1349-1353. DOI: 10.12449/JCH240711

Abstract(323)

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Objective To investigate the serum level of 25-hydroxyvitamin D in patients with nonalcoholic fatty liver disease （NAFLD） and obesity， as well as the correlation of 25-hydroxyvitamin D with liver function， blood lipids， and inflammatory indicators. Methods A total of 90 patients with NAFLD who atten...

Association between sleep disorders and different stages of nonalcoholic fatty liver disease

Jingjie ZHAO, Xinyu ZHAO, Chaoru HAN, Kaihui XIAO, Zhengzhao LU, Linyan QIN, Dong XU, Hong YOU

2024, 40(7): 1354-1359. DOI: 10.12449/JCH240712

Abstract(341)

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Abstract:
Objective To investigate the association of sleep disorders with the development and progression of nonalcoholic fatty liver disease （NAFLD）. Methods A total of 1 868 participants from the health examination cohort and fatty liver cohort of Beijing Friendship Hospital from June 2022 to June 2023 wer...

Association between Helicobacter pylori and nonalcoholic fatty liver disease： A Meta-analysis

Yuzhen YU, Liewang QIU, Ping HE

2024, 40(7): 1360-1369. DOI: 10.12449/JCH240713

Abstract(365)

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Abstract:
Objective To investigate the association between Helicobacter pylori infection and nonalcoholic fatty liver disease （NAFLD）. Methods This study was conducted acoording to the PRISMA guideline， with a PROSPERO registration number of CRD42023408932. Databases including PubMed， the Cochrane Library， We...

Autoimmune Liver Disease

Effect of ursodeoxycholic acid on symptoms after severe acute respiratory syndrome coronavirus 2 infection in patients with primary biliary cholangitis and their family members

Gui JIA, Chunmei YANG, Xiufang WANG, Juan DENG, Ruiqing SUN, Linhua ZHENG, Yulong SHANG, Ying HAN

2024, 40(7): 1370-1374. DOI: 10.12449/JCH240714

Abstract(421)

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Abstract:
Objective To investigate the effect of ursodeoxycholic acid （UDCA） on the symptoms after severe acute respiratory syndrome coronavirus 2 （SARS-CoV-2） infection in patients with primary biliary cholangitis （PBC） and their family member. Methods A questionnaire survey was conducted to collect related ...

Liver Fibrosis and Liver Cirrhosis

Influencing factors for rebleeding and 5-year survival rate after treatment in patients with liver cirrhosis and spontaneous splenorenal shunt

Chengzhao WENG, Wei JIANG, Shiyao CHEN, Linlin ZHENG

2024, 40(7): 1375-1381. DOI: 10.12449/JCH240715

Abstract(355)

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Objective To investigate the influencing factors for rebleeding and 5-year survival rate after treatment in patients with liver cirrhosis and spontaneous splenorenal shunt （SSRS）， and to provide a basis for clinical prognostic assessment. Methods A total of 95 patients with liver cirrhosis and SSRS ...

Effect of miRNA-933 on the apoptosis and proliferation of LX-2 cells and its molecular mechanism

Long HAI, Lina MA, Xia LUO, Xiangchun DING

2024, 40(7): 1382-1389. DOI: 10.12449/JCH240716

Abstract(537)

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Objective To investigate the regulatory effect of miRNA-933 on the apoptosis and proliferation of human hepatic stellate cell line LX-2 and its mechanism. Methods Firstly， with human liver tissue for research， gene microarray technology was used to detect the differentially expressed genes in liver ...

Liver Neoplasm

Expression and clinical significance of cell cycle protein-dependent kinase 1 and aurora kinase A in the serum of patients with hepatitis B virus-related hepatocellular carcinoma

Yanfang HE, Jiaojiao XIE, Lanlan ZHENG, Cai GUO, Yanhua MA

2024, 40(7): 1390-1396. DOI: 10.12449/JCH240717

Abstract(514)

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Objective To investigate the value of serum cell cycle protein-dependent kinase 1 （CDK1） and aurora kinase A （AURKA） in the diagnosis of patients with hepatitis B virus-related hepatocellular carcinoma （HBV-HCC）. Methods A total of 50 HBV-HCC patients， 50 patients with hepatitis B virus-related live...

Efficacy and safety of three-dimensional visualization technology in assisting ablation therapy for hepatocellular carcinoma： A Meta-analysis

Kaifu LI, Yongcheng TANG, Hao TANG, Xi ZHANG, Benjian GAO, De LUO, Song SU, Bo LI, Xiaoli YANG

2024, 40(7): 1397-1403. DOI: 10.12449/JCH240718

Abstract(323)

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Objective To systematically evaluate the efficacy and safety of three-dimensional visualization technology in assisting ablation therapy for hepatocellular carcinoma. Methods This study was conducted according to PRISMA guidelines， with a PROSPERO registration number of CRD42023488398. PubMed， Embas...

Value of contrast-enhanced ultrasound combined with shear wave elastography in the diagnosis of benign and malignant liver tumors： A Meta-analysis

Jun SONG, Lujia NI, Hanyu ZHANG, Xingzhao LI

2024, 40(7): 1404-1410. DOI: 10.12449/JCH240719

Abstract(346)

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Objective To investigate the value of contrast-enhanced ultrasound （CEUS） combined with shear wave elastography （SWE） in the diagnosis of liver tumors. Methods This study was conducted according to the PRISMA guideline， with a PROSPERO registration number of CRD42023491288. PubMed， Embase， the Cochr...

Performance of a nomogram model established based on clinical indices and magnetic resonance imaging signs in the diagnosis of traditional Chinese medicine syndrome types of primary liver cancer

Ying WANG, Xirong ZHANG

2024, 40(7): 1411-1419. DOI: 10.12449/JCH240720

Abstract(337)

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Objective To investigate the performance of a nomogram model established based on clinical indices and magnetic resonance imaging （MRI） signs in determining the traditional Chinese medicine （TCM） syndrome types of primary liver cancer. Methods A retrospective analysis was performed for the clinical ...

Role and prognostic value of matrix metalloproteinase-7 in the migration and immune cell infiltration of hepatocellular carcinoma

Shuyan LIU, Qichang YANG, Yi SHEN, Hong ZHOU, Jinfeng QIAN

2024, 40(7): 1420-1427. DOI: 10.12449/JCH240721

Abstract(394)

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Objective To investigate the role and prognostic value of matrix metalloproteinase-7 （MMP7） in the migration and immune cell infiltration of hepatocellular carcinoma. Methods MMP7_siRNA for downregulating the target gene MMP7 and pMMP7 for upregulating MMP7 were constructed and were used to transfec...

Biliary Disease

Expression of Midkine in cholangiocarcinoma and its value in predicting prognosis based on bioinformatics analysis

Yueyue GU, Shumin YU, Xiujuan CHANG, Xudong GAO, Jiagan HUANG, Xiaodong JIA, Zhen ZENG

2024, 40(7): 1428-1437. DOI: 10.12449/JCH240722

Abstract(414)

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Objective To investigate the expression of Midkine （MDK） in cholangiocarcinoma （CCA） and its value in predicting the prognosis of CCA， as well as the potential mechanism of the effect of MDK on the progression of CCA. Methods The data of CCA samples were obtained from TCGA database to analyze the di...

Pancreatic Disease

Influencing factors for chronic pancreatitis complicated by pancreatogenic portal hypertension and establishment of a predictive model

Jiani YANG, Zhini MA, Yingxia HU, Zongshuai LI, Yan LIU, Hairong ZHANG, Yinglei MIAO

2024, 40(7): 1438-1445. DOI: 10.12449/JCH240723

Abstract(524)

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Objective To investigate the influencing factors for chronic pancreatitis （CP） complicated by pancreatogenic portal hypertension （PPH）， and to establish a predictive model. Methods A retrospective analysis was performed for the clinical data of 99 patients with CP complicated by PPH who were hospita...

Case Report

Clinical cure of acute hepatitis B virus infection-related liver failure with HBsAg seroconversion： A case report

Xufeng QUAN, Shue XIONG, Wenqing ZHOU, Ruxia ZHOU, Jia LIU, Xin ZHENG

2024, 40(7): 1446-1449. DOI: 10.12449/JCH240724

Abstract(325)

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About 1% of the patients with acute hepatitis B can progress to acute liver failure， and 75% of the patients with hepatitis B virus （HBV）-related acute liver failure need to undergo liver transplantation or face death. This article reports a patient with HBV infection-related acute liver failure who...

Review

Role of lipophagy in the prevention and treatment of nonalcoholic fatty liver disease

Zhili XIAO, Chenxia LU, Danni ZHOU, Zhuangzhuang CHEN, Mingzhong XIAO, Xiaodong LI

2024, 40(7): 1450-1458. DOI: 10.12449/JCH240725

Abstract(724)

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Nowadays， the prevalence of nonalcoholic fatty liver disease （NAFLD） is constantly rising in China and globally， and its incidence rate is increasing year by year， which has seriously affected human life and health. Lipophagy is molecular chaperone-mediated autophagy and has the functions of promoti...

Mechanism of action of sterol regulatory element-binding proteins in nonalcoholic fatty liver disease and related therapeutic targets

Anqi LI, Peiran ZHAO, Yuqiang ZHAO, Rui WANG, Jing YANG

2024, 40(7): 1459-1465. DOI: 10.12449/JCH240726

Abstract(971)

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Nonalcoholic fatty liver disease （NAFLD） has become the most common liver disease in the world and is an important risk factor for the progression to hepatocellular carcinoma. However， the pathogenesis of NAFLD remains unclear， and there is still a lack of specific treatment measures. Sterol regulat...

Mechanism of action of follicular helper T cells in autoimmune hepatitis

Longlong LUO, Lifei WANG, Guojing XING, Ying ZHENG, Lixia LU, Chuyi LI, Bin LI, Jun MA, Xiaohui YU, Jiucong ZHANG

2024, 40(7): 1466-1469. DOI: 10.12449/JCH240727

Abstract(380)

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Autoimmune hepatitis （AIH） is a type of chronic hepatitis caused by the attack of hepatocytes by the autoimmune system， and with the prolongation of disease course， it may gradually progress to liver cirrhosis and even hepatocellular carcinoma. Although great achievements have been made in the under...

Advances in the diagnosis and treatment of intrahepatic cholangiocarcinoma

Di HU, Jintao HUANG, Binyan ZHONG, Jian SHEN, Xiaoli ZHU

2024, 40(7): 1470-1476. DOI: 10.12449/JCH240728

Abstract(966)

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Intrahepatic cholangiocarcinoma （ICC） is a relatively rare type of primary liver cancer， and its incidence rate has gradually increased in recent years. Due to its insidious onset and atypical clinical symptoms， most patients are already in the advanced stage of the disease at the time of confirmed ...

Research advances in the mechanism of action of traditional Chinese medicine in inhibiting angiogenesis in hepatocellular carcinoma

Xiangxiang LI, Zhen WANG, Xing YANG, Suling LI

2024, 40(7): 1477-1485. DOI: 10.12449/JCH240729

Abstract(633)

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Angiogenesis is a key process in the development and progression of hepatocellular carcinoma （HCC） and can provide essential material conditions for the proliferation， invasion， and metastasis of HCC cells. Inhibition of angiogenesis has become a research hotspot in the field of HCC therapy. Traditi...

Research advances in liver cancer organoids

Li ZHAO, Ziqi GUO, Yong YANG, Hongxin YANG

2024, 40(7): 1486-1492. DOI: 10.12449/JCH240730

Abstract(741)

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Organoids are a novel disease model that is self-assembled from stem cells or malignant tumors and is used in clinical research. They are similar to tissues and organs in the body and have partially functional 3D cell structures. There are two types of traditional models for liver cancer research， i...

Mechanism of action and potential therapeutic targets of ferroptosis suppressor protein 1 in liver diseases

Sisi WANG, Yaru WANG, Rui LIU, Jie QIN

2024, 40(7): 1493-1497. DOI: 10.12449/JCH240731

Abstract(751)

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Ferroptosis suppressor protein 1 （FSP1） is another major ferroptosis regulator besides glutathione peroxidase 4， which can scavenge intracellular reactive oxygen species and lipid peroxides and inhibit ferroptosis. In view of the key role of the liver in iron and lipid metabolism and its susceptibil...

Metal ion metabolism： New ideas for the traditional Chinese medicine prevention and treatment of chronic liver disease

Xinhua GUO, Jiahui WANG, Xuelin DUAN, Yue PENG, Tiejian ZHAO, Yang ZHENG, Bin ZHAO

2024, 40(7): 1498-1504. DOI: 10.12449/JCH240732

Abstract(408)

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Chronic liver disease （CLD） tends to have a high incidence rate and impose a serious burden on society and families. Studies have shown that metal ion metabolism is closely associated with CLD， and some Chinese herbal medicines can play a role in the prevention and treatment of CLD by regulating met...