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Vol.40 No.8 (286 in total) Aug. 2024
Theme Issue: Progress in Basic and Clinical Research on Herb-induced Liver Injury
Executive Chief Editor: LIU Chenghai  
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
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Editorial
Research advances and challenges in herb-induced liver injury
Chenghai LIU
2024, 40(8): 1505-1511. DOI: 10.12449/JCH240801
Abstract(837) HTML (602) PDF (791KB)(203) Cited By (1)
Abstract:
Herb-induced liver injury （HILI） shows a high incidence rate and has great impacts on the clinical medication safety of traditional Chinese medicine and the healthy development of the industry. In recent years， the research on HILI has attracted wide attention and made remarkable progress， and relat...
Expert Forum
The material basis and toxic mechanism of herb-induced liver injury
Xueying LIU, Huihui SHI, Haowen WANG, Tao YANG
2024, 40(8): 1512-1518. DOI: 10.12449/JCH240802
Abstract(1029) HTML (604) PDF (1503KB)(168) Cited By (2)
Abstract:
Herb-induced liver injury （HILI） tends to have complex toxic material basis and toxic mechanism， which greatly affects the safety of traditional Chinese medicine. This article summarizes the main toxic components of Chinese herbal medicine causing liver injury and their mechanism of action. The toxi...
Influence of combined drug administration on herb-induced liver injury
Hui ZHENG, Rong SUN
2024, 40(8): 1519-1524. DOI: 10.12449/JCH240803
Abstract(422) HTML (452) PDF (718KB)(70)
Abstract:
With the wide application of traditional Chinese medicine （TCM） globally and combined drug use in clinical practice， there have been significant increases in herb-induced liver injury （HILI） events and drug safety events， bringing great challenges to the research and development of new TCM drugs and...
Phenotypic characteristics and toxicological mechanisms of herb-induced liver injury
Tingting HE, Zhaofang BAI, Jiabo WANG, Xiaohe XIAO
2024, 40(8): 1525-1532. DOI: 10.12449/JCH240804
Abstract(586) HTML (487) PDF (955KB)(107) Cited By (1)
Abstract:
In order to deal with the problem of the safety of Chinese herbal medicine in a scientific way and further meet the growing health needs of people， it is particularly important to deepen the research on herb-induced liver injury. This article elaborates on the phenotypic characteristics and toxicolo...
Diagnosis of herb-induced liver injury： Challenges in practice
Yinuo DONG, Yang ZHI, Jieting TANG, Yimin MAO
2024, 40(8): 1533-1537. DOI: 10.12449/JCH240805
Abstract(414) HTML (401) PDF (666KB)(87)
Abstract:
With the increasingly wide application of herbal medicines and dietary supplements worldwide， herb-induced liver injury （HILI） has become an important etiology of drug-induced liver injury. Due to the diverse manifestations of HILI， the difficulty in medical history collection， and the lack of speci...
Management and treatment of herb-induced liver injury
Xin SUN, Qiong LUO, Tao YANG, Chenghai. LIU
2024, 40(8): 1538-1542. DOI: 10.12449/JCH240806
Abstract(570) HTML (441) PDF (663KB)(100)
Abstract:
Due to the diverse application forms of Chinese herbal medicine products， the wide range of users， and the complex conditions of medication in China， adverse events including herb-induced liver injury （HILI） occur frequently in recent years. In order to further understand HILI and standardize its ri...
Guideline
Expert recommendations on screening， testing and management for hepatitis B virus infection in adults
Society of Prevention and Control of Infectious Diseases of Chinese Preventive Medicine Association, Working Committee of Promoting the Elimination of Viral Hepatitis of Chinese Preventive Medicine Association
2024, 40(8): 1543-1550. DOI: 10.12449/JCH240807
Abstract(806) HTML (416) PDF (1971KB)(303) Cited By (3)
Abstract:
The prevalence of hepatitis B represents a significant public health concern with a heavy disease burden. In China， there is still a big gap between the current diagnosis and treatment rates of hepatitis B and the goal of eliminating viral hepatitis as a public health threat by 2030 set by the World...
Expert recommendations on hepatitis B vaccination in adults
Working Committee of Promoting the Elimination of Viral Hepatitis of Chinese Preventive Medicine Association, Society of Prevention and Control of Infectious Diseases of Chinese Preventive Medicine Association
2024, 40(8): 1551-1556. DOI: 10.12449/JCH240808
Abstract(505) HTML (370) PDF (722KB)(222) Cited By (4)
Abstract:
In order to achieve the target of eliminating viral hepatitis as a public health threat by 2030 and to prioritize the role of hepatitis B vaccination in reducing new hepatitis B virus infections， the Chinese Preventive Medicine Association commissioned experts to develop the Expert Recommendations o...
Chinese practice guideline for the prevention and treatment of mother-to-child transmission of hepatitis B virus （version 2024）
Infectious Diseases Physicians Branch， Chinese Medical Doctor Association, Chinese Society of Infectious Diseases， Chinese Medical Association
2024, 40(8): 1557-1566. DOI: 10.12449/JCH240809
Abstract(1253) HTML (761) PDF (1365KB)(573) Cited By (8)
Abstract:
The 2019 Chinese practice guideline for the prevention and treatment of mother-to-child transmission of hepatitis B virus developed by Chinese Society of Infectious Diseases， Chinese Medical Association， has shown a good guiding effect in standardizing the process for blocking the mother-to-child tr...
An excerpt of EASL-EASD-EASO clinical practice guidelines on the management of metabolic dysfunction-associated steatotic liver disease in 2024
Wenjing NI, Nan GENG, Xue BAI, Jie LI
2024, 40(8): 1567-1574. DOI: 10.12449/JCH240810
Abstract(927) HTML (407) PDF (1636KB)(267) Cited By (1)
Abstract:
In June 2024， the European Association for the Study of the Liver， the European Association for the Study of Diabetes， and the European Association for the Study of Obesity jointly released the latest edition of clinical practice guidelines on the management of metabolic dysfunction-associated steat...
An excerpt of Asian Pacific Association for the Study of the Liver clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure in 2024
Jiaxuan HU, Tao HAN
2024, 40(8): 1575-1578. DOI: 10.12449/JCH240811
Abstract(443) HTML (337) PDF (558KB)(111)
Abstract:
Acute-on-chronic liver failure （ACLF） is a syndrome characterized by the rapid progression of organ failure and has a high short-term mortality rate. Kidney is one of the most frequently affected extrahepatic organs in ACLF patients. Recently Asian Pacific Association for the Study of the Liver （APA...
Fatty Liver Disease
Risk factors for the development of advanced liver fibrosis in nonalcoholic fatty liver disease and establishment of a nomogram model
Jinqiu YANG, Wenxia ZHAO, Cheng ZHOU, Tong LIU
2024, 40(8): 1579-1584. DOI: 10.12449/JCH240812
Abstract(404) HTML (129) PDF (1014KB)(45) Cited By (4)
Abstract:
Objective To investigate the risk factors for the development of advanced liver fibrosis by analyzing the clinical features of patients with in nonalcoholic fatty liver disease （NAFLD） and advanced liver fibrosis， and to establish a nomogram model for predicting the risk of advanced liver fibrosis. ...
Association between nonalcoholic fatty liver disease and osteoporosis in elderly patients
Qian XUE, Chunling JIA, Jingtong WANG
2024, 40(8): 1585-1590. DOI: 10.12449/JCH240813
Abstract(354) HTML (144) PDF (642KB)(38)
Abstract:
Objective To investigate the association between nonalcoholic fatty liver disease （NAFLD） and osteoporosis in elderly patients. Methods A total of 824 patients， aged ≥60 years， who were hospitalized in Department of Gerontology， Peking University People’s Hospital， from June 2016 to April 2023 were ...
Association of metabolic associated fatty liver disease with carotid atherosclerotic plaque and stenosis
Yingdie ZHU, Zhijiao ZHANG, Guilin ZHANG, Yunkun GAO, Mengyao ZHENG, Hua HUANG, Gongfang ZHAO
2024, 40(8): 1591-1597. DOI: 10.12449/JCH240814
Abstract(415) HTML (127) PDF (683KB)(28)
Abstract:
Objective To investigate the association between metabolic associated fatty liver disease （MAFLD） and carotid atherosclerotic plaque. Methods A total of 1 107 patients who were hospitalized in The Second Affiliated Hospital of Kunming Medical University from July， 2014 to December， 2022 were enrolle...
Autoimmune Liver Disease
Primary biliary cholangitis with metabolic associated fatty liver disease： Clinical features and risk factors
Linna YUAN, Yihui CHEN, Hengbin NA, Jie LU, Ye LIU, Wu LI
2024, 40(8): 1598-1604. DOI: 10.12449/JCH240815
Abstract(411) HTML (154) PDF (693KB)(49)
Abstract:
Objective To investigate the clinical features and risk factors of primary biliary cholangitis （PBC） comorbid with metabolic associated fatty liver disease （MAFLD） and the interaction between the two diseases. Methods A total of 187 patients who were diagnosed with PBC， MAFLD， or PBC with MAFLD in T...
Liver Fibrosis and Liver Cirrhosis
Establishment and evaluation of a nomogram prediction model for overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with liver cirrhosis and esophagogastric variceal bleeding
Xinyi LI, Jiaojiao LI, Wei SUN
2024, 40(8): 1605-1611. DOI: 10.12449/JCH240816
Abstract(337) HTML (134) PDF (1030KB)(28) Cited By (1)
Abstract:
Objective To establish a nomogram prediction model for the development of overt hepatic encephalopathy （OHE） in patients with liver cirrhosis undergoing transjugular intrahepatic portosystemic shunt （TIPS） after esophagogastric variceal bleeding， and to evaluate the predictive ability of the model. ...
Effect of Yiguan Decoction on the efficacy of M1 bone marrow-derived macrophages in treatment of liver cirrhosis rats and its mechanism
Mengyao ZONG, Xun JIAN, Danyang WANG, Yannan XU, Xinrui ZHENG, Feifei XING, Gaofeng CHEN, Jiamei CHEN, Ping LIU, Yongping MU
2024, 40(8): 1612-1619. DOI: 10.12449/JCH240817
Abstract(388) HTML (285) PDF (4914KB)(26)
Abstract:
Objective To investigate the effect and mechanism of Yiguan Decoction （YGJD） on the efficacy of M1 bone marrow-derived macrophages （M1-BMDMs） in the treatment of rats with liver cirrhosis induced by 2-AAF/CCl4. Methods BMDMs were isolated and induced into M1-BMDMs by lipopolysaccharide. A total of 5...
Liver Neoplasm
Efficacy and safety of tyrosine kinase inhibitor combined with immune checkpoint inhibitor as the second-line therapy for advanced hepatocellular carcinoma
Hong NIE, Binyan ZHONG, Jian SHEN, Xiaoli ZHU
2024, 40(8): 1620-1626. DOI: 10.12449/JCH240818
Abstract(317) HTML (313) PDF (1031KB)(30) Cited By (1)
Abstract:
Objective To investigate the efficacy and safety of tyrosine kinase inhibitor （TKI） combined with immune checkpoint inhibitor as the second-line therapy for advanced hepatocellular carcinoma （HCC）. Methods A retrospective analysis was performed for the clinical data of 63 patients with advanced HCC ...
Other Liver Disease
Liver disease phenotypes and clinical features of patients with different genotypes of Wilson’s disease
Yuanzhi HUANG, Fuchuan WANG, Yi DONG, Zhiqiang XU, Yinjie GAO, Jianguo YAN, Lili CAO, Danni FENG, Min ZHANG
2024, 40(8): 1627-1632. DOI: 10.12449/JCH240819
Abstract(431) HTML (349) PDF (769KB)(42)
Abstract:
Objective To investigate the liver disease phenotypes and clinical features of patients with different genotypes of Wilson’s disease （WD）. Methods A retrospective analysis was performed for 163 patients with WD who were diagnosed and underwent genetic testing in The Fifth Medical Center of Chinese P...
Value of intestinal fatty acid binding protein in predicting the development and progression of acute-on-chronic liver failure
Caijun HAN, Meihua PIAO, Yuan HUANG, Zhengxie WU, Xing JIN, Guangyi LI
2024, 40(8): 1633-1638. DOI: 10.12449/JCH240820
Abstract(411) HTML (120) PDF (902KB)(32)
Abstract:
Objective To investigate the value of intestinal fatty acid binding protein （I-FABP） in predicting the development and progression of acute-on-chronic liver failure （ACLF）. Methods A retrospective analysis was performed for the clinical data of 168 patients with decompensated liver cirrhosis who wer...
Value of urinary liver fatty acid-binding protein in predicting the short-term prognosis of patients with acute-on-chronic liver failure
Hualan WU, Changze HONG, Xiuhua JIANG, Jinjun CHEN
2024, 40(8): 1639-1645. DOI: 10.12449/JCH240821
Abstract(256) HTML (137) PDF (964KB)(29)
Abstract:
Objective To investigate the value of liver fatty acid-binding protein （L-FABP） in predicting the severity and short-term prognosis of patients with acute-on-chronic liver failure （ACLF）. Methods A total of 149 patients with ACLF were selected from a prospective multicenter cohort assessing the plat...
Therapeutic effect of mesenchymal stem cells on acute-on-chronic liver failure： A Meta-analysis
Hang DING, Xiaofen LI, Yan XIONG, Yanyan LI, Xiuji CHEN, Xiaolin WANG
2024, 40(8): 1646-1652. DOI: 10.12449/JCH240822
Abstract(399) HTML (135) PDF (1767KB)(34) Cited By (1)
Abstract:
Objective To systematically evaluate the efficacy and safety of mesenchymal stem cells （MSC） in the treatment of acute-on-chronic liver failure （ACLF）. Methods This study was conducted according to PRISMA guidelines， with the PROSPERO registration number of CRD42024517851. PubMed， Embase， Wanfang Da...
Association between preoperative N-terminal pro-brain natriuretic peptide and acute kidney injury after liver transplantation
Naifan PAN, Xuesong SONG
2024, 40(8): 1653-1660. DOI: 10.12449/JCH240823
Abstract(316) HTML (191) PDF (659KB)(15)
Abstract:
Objective To investigate the association between preoperative N-terminal pro-brain natriuretic peptide （NT-proBNP） and acute kidney injury （AKI） after liver transplantation （LT）， to clarify the influencing factors for AKI after liver transplantation， and to provide diagnostic reference indicators fo...
Pancreatic Disease
Value of triglyceride glucose-body mass index in evaluating the severity of hyperlipidemic acute pancreatitis
Pingping LUO, Qun LIU, Liwen HUANG
2024, 40(8): 1661-1665. DOI: 10.12449/JCH240824
Abstract(361) HTML (211) PDF (610KB)(29)
Abstract:
Objective To investigate the value of triglyceride glucose-body mass index （TyG-BMI） index in predicting the severity of hyperlipidemic acute pancreatitis （HLAP）. Methods A retrospective analysis was performed for the clinical data of 185 patients with HLAP who were admitted to Tianyou Hospital Affi...
Case Report
Primary biliary cholangitis-autoimmune hepatitis overlap syndrome comorbid with pulmonary cryptococcosis： A case report
Mingming ZHANG, Huan LIU, Dongmei ZHANG, Dongbo WU, Hong TANG
2024, 40(8): 1666-1669. DOI: 10.12449/JCH240825
Abstract(370) HTML (145) PDF (1960KB)(57)
Abstract:
Patients with overlap syndrome （OS） of autoimmune liver disease may present with more than one biochemical， immunological， histological or cholangiography features of autoimmune liver disease （AILD） and often require a combination of immunosuppressants for treatment. Pulmonary cryptococcosis is a ty...
Review
The role of circadian clock-controlled mitochondrial dynamics in nonalcoholic fatty liver disease
Ce ZHANG, Jiarui MIAO, Xu FAN
2024, 40(8): 1670-1676. DOI: 10.12449/JCH240826
Abstract(400) HTML (152) PDF (1259KB)(46) Cited By (1)
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is a disease closely associated with metabolic abnormalities and is currently one of the most common chronic liver diseases. Mitochondria are highly dynamic organelles involved in a variety of metabolic and bioenergetic pathways in the liver， and they respond...
The role of necroptosis in liver fibrosis
Xuan WU, Hui LI, Haijian DONG, Xikun YANG, Kaixin WANG
2024, 40(8): 1677-1681. DOI: 10.12449/JCH240827
Abstract(343) HTML (227) PDF (629KB)(30)
Abstract:
As a crucial link in the progression of various chronic liver diseases to liver cirrhosis， liver fibrosis affects the prognosis and outcome of chronic liver diseases. Necrotosis is a novel pattern of programmed cell death （PCD）， and studies have shown that it plays an important role in the pathophys...
Advances in the application of direct-acting antivirals in patients with hepatitis C cirrhosis
Xiping RAN, Dachuan CAI
2024, 40(8): 1682-1687. DOI: 10.12449/JCH240828
Abstract(291) HTML (117) PDF (667KB)(26)
Abstract:
Chronic hepatitis C virus （HCV） infection can lead to liver cirrhosis， and complications after liver cirrhosis， including hepatocellular carcinoma （HCC）， are the leading causes of death in patients with chronic liver diseases. Antiviral therapy can help to realize sustained virologic response， impro...
Association of lipid metabolism reprogramming with the development and progression of primary liver cancer
Feiyan LI, Minggang WANG, Dewen MAO, Riyun ZHANG, Na WANG, Yinbing LUO, Xiaoping LIU, Yupei LIN
2024, 40(8): 1688-1692. DOI: 10.12449/JCH240829
Abstract(379) HTML (326) PDF (617KB)(39) Cited By (1)
Abstract:
Lipid metabolism， as the basis of life maintenance， is a prerequisite for cell survival， and lipid homeostasis can rapidly respond to metabolic changes in a coordinated manner. In cancers， there is an increase in lipid metabolism in cancer cells to meet the requirements for plasma membrane synthesis...
Role of ferroptosis in hepatic ischemia-reperfusion injury
Jiaxin LIANG, Baolin XU, Yu CHENG, Yong WEI
2024, 40(8): 1693-1698. DOI: 10.12449/JCH240830
Abstract(433) HTML (147) PDF (859KB)(39)
Abstract:
Ferroptosis is a new type of regulatory cell death and is mainly caused by changes in intracellular iron homeostasis due to various inducers， which promotes the occurrence of iron ion-dependent lipid peroxidation， thereby leading to the accumulation of toxic lipid peroxides and finally resulting in ...
Role of biliary microbiota in the development and progression of common biliary tract diseases
Li HUO, Zhihui CHANG
2024, 40(8): 1699-1703. DOI: 10.12449/JCH240831
Abstract(415) HTML (167) PDF (1104KB)(80)
Abstract:
The composition of biliary microbiota is closely associated with the development and progression of biliary diseases， and imbalance of biliary microbiota may lead to a series of biliary tract diseases such as gallstones， biliary tract infections， autoimmune cholangitis， and cholangiocarcinoma. This ...
Molecular mechanism of traditional Chinese medicine active components in regulating glucose metabolism against cholangiocarcinoma
Fangyan ZHAO, Shan LI, Xiangqi WANG, Yi YIN
2024, 40(8): 1704-1708. DOI: 10.12449/JCH240832
Abstract(378) HTML (341) PDF (681KB)(34) Cited By (1)
Abstract:
Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset， severe conditions， a high degree of malignancy， and an extremely poor prognosis. Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma， and the glucose metabolism pathway of cholangiocar...
Research advances in hereditary pancreatitis in children
Xiaozheng YU, Jie WU
2024, 40(8): 1709-1714. DOI: 10.12449/JCH240833
Abstract(317) HTML (199) PDF (701KB)(27) Cited By (1)
Abstract:
Hereditary pancreatitis （HP） is one of the major causes of pancreatitis in children and has a high risk of carcinogenesis after they become adults. This article reviews the recent research advances in HP， including historical development， epidemiology， pathogenic mechanism， and related pathogenic ge...
Pathogenesis of pancreatogenic diabetes
Chenxiao WANG, Xiao WANG, Xiwang WANG, Jingjing JIN, Ying WANG, Jiangkai LIU, Shuxun YAN
2024, 40(8): 1715-1720. DOI: 10.12449/JCH240834
Abstract(359) HTML (138) PDF (941KB)(23)
Abstract:
Pancreatogenic diabetes is a type of diabetes secondary to pancreatic exocrine disease， and it was officially named by American Diabetes Association in 2014. Chronic pancreatitis and pancreatic cancer are the most common causes of pancreatogenic diabetes. The pathogenesis of this disease remains unc...
Introduction of High - quality Articles in Foreign Journals
Journal of Hepatology｜Endothelial POFUT1 controls injury-induced liver fibrosis by repressing fibrinogen synthesis
2024, 40(8): 1537-1537. DOI: 10.12449/JCH2408.gwqkjpwzjj1
Abstract(241) HTML (101) PDF (894KB)(14)
Abstract:
Nutrition Journal｜Effects of vitamin D supplementation on liver fibrogenic factors, vitamin D receptor and liver fibrogenic microRNAs in metabolic dysfunction-associated steatotic liver disease (MASLD) patients: an exploratory randomized clinical trial
2024, 40(8): 1626-1626. DOI: 10.12449/JCH2408.gwqkjpwzjj2
Abstract(226) HTML (96) PDF (896KB)(14)
Abstract:
Journal of the American Medical Association｜Aspirin for metabolic dysfunction-associated steatotic liver disease without cirrhosis: A randomized clinical trial
2024, 40(8): 1652-1652. DOI: 10.12449/JCH2408.gwqkjpwzjj3
Abstract(197) HTML (92) PDF (903KB)(22)
Abstract:
Acknowledgements
Current reviewers
2024, 40(8): 1532-1532. DOI: 10.12449/JCH2408.zhixie
Abstract(129) HTML (72) PDF (873KB)(9)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

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