Association between nonalcoholic fatty liver disease and osteoporosis in elderly patients

Qian XUE; Chunling JIA; Jingtong WANG

doi:10.12449/JCH240813

Volume 40 Issue 8

Aug. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(8): 1585-1590

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Association between nonalcoholic fatty liver disease and osteoporosis in elderly patients

DOI: 10.12449/JCH240813

Department of Gerontology，Peking University People’s Hospital，Beijing 100044，China

Research funding:

National Project of Multidisciplinary Diagnosis and Treatment of Major Diseases (2020);

International Institute of Population Health, Peking University Health Science Center (JKCJ202102)

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Corresponding author: WANG Jingtong， wangjingtong11@163.com （ORCID： 0000-0002-8203-1323）
Received Date: 2023-11-23
Accepted Date: 2024-01-23
Published Date: 2024-08-25

Abstract

Abstract

Objective To investigate the association between nonalcoholic fatty liver disease （NAFLD） and osteoporosis in elderly patients. Methods A total of 824 patients， aged ≥60 years， who were hospitalized in Department of Gerontology， Peking University People’s Hospital， from June 2016 to April 2023 were enrolled， with 398 patients in the osteoporosis group and 426 in the non-osteoporosis group. Related data were collected from all subjects， including general information， blood biochemical parameters， liver ultrasound， and bone mineral density measured by dual-energy X-ray examination. The independent-samples t test was used for comparison of normally distributed continuous data between two groups， and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups； the chi-square test was used for comparison of categorical variables； a binary Logistic regression analysis was used to investigate the independent risk factors for osteoporosis. Results Compared with the non-osteoporosis group， the osteoporosis group had a significantly higher age， a significantly higher proportion of female patients or patients with diabetes， and a significantly lower body mass index （all P<0.05）. The osteoporosis group had a significantly higher proportion of patients with NAFLD than the non-osteoporosis group （36.2% vs 24.6%， χ²=12.878， P<0.001）. Compared with the non-osteoporosis group， the osteoporosis group had significantly lower levels of hemoglobin， uric acid， and albumin and significantly higher levels of total cholesterol， low-density lipoprotein cholesterol （LDL-C）， bone-specific alkaline phosphatase， and tartrate-resistant acid phosphatase （all P<0.05）. The binary Logistic regression analysis showed that old age （odd ratio ［OR］=1.040， 95% confidence interval ［CI］： 1.015‍ ‍—‍ ‍1.066， P=0.002）， female sex （OR=4.089， 95%CI： 2.607‍ ‍—‍ ‍6.411， P<0.001）， NAFLD （OR=1.697， 95%CI： 1.076‍ ‍—‍ ‍2.678， P=0.023）， diabetes （OR=1.509， 95%CI： 1.008‍ ‍—‍ ‍2.260， P=0.046）， and LDL-C （OR=1.431， 95%CI： 1.010‍ ‍—‍ ‍2.029， P=0.044） were independent risk factors for osteoporosis in elderly patients. Considering the impact of diabetes on the research findings， a subgroup analysis was performed for the patients without diabetes， and the results showed that NAFLD （OR=1.573， 95%CI： 1.015‍ ‍—‍ ‍2.439， P=0.043） was an independent risk factor for osteoporosis in the elderly patients without diabetes. Conclusion NAFLD， old age， and female sex are independent risk factors for osteoporosis in elderly patients.
- Non-Alcoholic Fatty Liver Disease,
- Osteoporosis,
- Aged

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References

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Association between nonalcoholic fatty liver disease and osteoporosis in elderly patients

DOI: 10.12449/JCH240813

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