Theme Issue: Clinical Application and Research Progress of Albumin in Liver Disease
Chief Editor: JIA Jidong
Albumin is the most abundant protein in human plasma, and in addition to the function of maintaining plasma colloid osmotic pressure, it also has the functions of material transport, detoxification, maintaining vascular integrity, antioxidation, anti-inflammat...
As an important protein synthesized by the liver, albumin is one of the most important markers for liver function, and its structure and function change with the progression of liver injury. Latest studies have shown that albumin in the disease state is not on...
Albumin is synthesized in the liver, and in case of severe liver injury, albumin synthesis is reduced with structural alterations (such as an increase in methylation and glycosylation), leading to a significant reduction in effective albumin in circulation. Al...
Human serum albumin (HSA) is the most abundant protein in plasma and has many biological functions and clinical applications. An adequate and stable supply of functional HSA molecules that are easy to store and have a long half-life is still an unmet clinical ...
Albumin is widely used in clinical practice, and the rationality of trial design directly affects the reliability of research findings and clinical application value. This article reviews the key statistical considerations in the design of albumin clinical tri...
Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous tumor, and molecular profiling serves as the foundation for personalized treatment of ICC. Accurate detection methods are clinically significant for comprehensively screening patients suitable for...
In November 2024, the Expert Group on Alcohol-related Liver Disease released a position statement on metabolic dysfunction and alcohol-related liver disease (MetALD). MetALD is a new subtype of steatotic liver disease and refers to MASLD patients with a relati...
Hepatic angiomyolipoma (HAML) is a rare benign mesenchymal tumor frequently observed in middle-aged women. Due to the absence of prominent symptoms in the early stage and the lack of specific imaging findings, the diagnosis of this disease can be challenging, ...
Some patients with drug-induced liver injury (DILI) may present with similar features to patients with autoimmune hepatitis (AIH), and such cases are defined as drug-induced autoimmune-like hepatitis (DI-ALH). In 2022, the European Association for the Study of...
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. The pathogenesis of AIH remains unclear, but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system, while the speci...
Hepatitis B cirrhosis is the most significant component of liver cirrhosis in China, and there is a significant increase in the mortality rate of patients after progression from hepatitis to liver cirrhosis. A large number of studies have shown that gut microb...
The Model for End-Stage Liver Disease (MELD) score is currently used to prioritize liver allocation for cirrhotic patients awaiting liver transplantation in the world. With the application of MELD score in transplantation for patients with severe conditions, s...
Mesenchymal stem cells (MSCs) have emerged as a promising cellular therapy for end-stage liver disease (ESLD) due to their robust self-regenerative, paracrine, and immunomodulatory characteristics, providing new directions for the treatment of advanced liver d...
Acute-on-chronic liver failure (ACLF) is a dangerous disease with severe conditions, rapid progression, and high short-term mortality. Intestinal flora and metabolites are closely associated with the development, progression, and pathogenesis of ACLF. During t...
Liver failure is a common severe syndrome of liver diseases with high mortality. The function and structural integrity of the intestinal barrier as an entity are closely associated with the development and progression of liver failure. The cGAS-STING signaling...
After 50 years of clinical development, endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred method for the clinical diagnosis and treatment of cholangio-pancreatic duct diseases; however, the major postoperative complications of ERCP...
Intrahepatic cholangiocarcinoma is a malignant tumor with an extremely poor prognosis, and its pathogenesis is complex and remains unclear. In recent years, more and more studies have focused on the role of bile-gut axis in the development and progression of i...
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant liver tumor, and due to the absence of symptoms in its early stage and the lack of effective treatment measures, patients tend to have an extremely low 5-year survival rate. The tumor stroma-immune mi...
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- 1Current situation in the research of Gilbert’s syndrome
- 2Review of acute pancreatitis scoring systems
- 3Clinical value of 13C-methacetin breath test for assessing liver function in patients with cirrhosis
- 4Studies on relevant gactors of Child-Pugh grading in hepatic cirrhosis
- 5Meta-analysis of 111 patients with nonalcoholic steatohepatitis-associated hepatocellular carcinoma
- 6Research state and prospect of hyponatremia in cirrhosis
- 7Relationship between Epstein-Barr virus infection and hepatic lesions in children
- 8Congenital bile acid synthesis defect and cholestatic liver disease
- 9Interventional treatment for Budd-Chiari syndrome:reports of 883 cases
- 10
- 1The guideline of prevention and treatment for chronic hepatitis B: a 2015 update
- 2Chinese guidelines for the management of acute pancreatitis ( Shenyang , 2019 )
- 3The guideline of prevention and treatment for chronic hepatitis B(2010 version)
- 4Comprehensive guidelines for the diagnosis and treatment of pancreatic cancer (2018 version)
- 5Consensus on the diagnosis and management of primary biliary cirrhosis (cholangitis)(2015)
- 6Diagnosis, management, and treatment of hepatocellular carcinoma (V2017)
- 7Consensus on the diagnosis and management of autoimmune hepatitis(2015)
- 8Current situation in the research of Gilbert’s syndrome
- 9Guidelines for the prevention and treatment of chronic hepatitis B (version 2019)
- 10
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