The development and application of genetically engineered human serum albumin

Yanhang GAO; Junqi NIU

doi:10.12449/JCH250304

Volume 41 Issue 3

Mar. 2025

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Article Navigation > Journal of Clinical Hepatology > 2025 > 41(3): 415-419

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The development and application of genetically engineered human serum albumin

DOI: 10.12449/JCH250304

Yanhang GAO^{1, 2, 3},
Junqi NIU^{1, 2, 3
,
,
,}

1.
Department of Hepatology，The First Hospital of Jilin University，Center of Infectious Diseases and Pathogen Biology，Changchun 130021，China
2.
Jilin Provincial Key Laboratory of Metabolic Liver Diseases，Jilin University，Changchun 130021，China
3.
China-Singapore Belt and Road Joint Laboratory on Liver Disease Research，Changchun 130021，China

Research funding:

National Natural Science Foundation of China (U24A20654);

National Natural Science Foundation of China (82170602);

The Project for Middle-aged and Young Excellent Technological Innovation Talents of Jilin Province (20220508079RC);

Natural Science Foundation for Self-Exploration Research of Jilin Province (YDZJ202401427ZYTS);

Jilin Provincial Key Laboratory of Metabolic Liver Diseases (YDZJ202502CXJD002);

National Key Research and Development Program of China (2024YFE0213800)

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Corresponding author: NIU Junqi， junqiniu@aliyun.com （ORCID： 0000-0002-1696-6008）
Received Date: 2025-01-13
Accepted Date: 2025-02-01
Published Date: 2025-03-25

Abstract

Abstract

Human serum albumin （HSA） is the most abundant protein in plasma and has many biological functions and clinical applications. An adequate and stable supply of functional HSA molecules that are easy to store and have a long half-life is still an unmet clinical need. Therefore， it is extremely necessary to develop alternative methods for large-scale production of HSA. Genetic engineering techniques can clone the HSA gene into microorganism， animal， and plant hosts for efficient expression， which provides new possibilities for the large-scale production of HSA. This article reviews the advances in recombinant HSA （rHSA） in different expression systems and the production of rHSA by xenogeneic animals such as pigs and cattle， in order to draw attention to the application potential of genetic engineering techniques in HSA production and the importance of rHSA in the biomedical field in future.
- Human Serum Albumin,
- Liver Diseases,
- Genetic Engineering

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References(15)

References

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The development and application of genetically engineered human serum albumin

DOI: 10.12449/JCH250304

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