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Vol.41 No.3 (293 in total) Mar. 2025

Theme Issue: Clinical Application and Research Progress of Albumin in Liver Disease 

Chief Editor: JIA Jidong

Beijing Friendship Hospital, Capital Medical University
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Editorial
Driving innovation and fostering collaboration to advance the development and clinical research of next-generation human serum albumin
Jidong JIA, Junqi NIU
2025, 41(3): 401-403. DOI: 10.12449/JCH250301
Abstract(68) HTML (18) PDF (508KB)(18)
Abstract:
Albumin is the most abundant protein in human plasma， and in addition to the function of maintaining plasma colloid osmotic pressure， it also has the functions of material transport， detoxification， maintaining vascular integrity， antioxidation， anti-inflammation， and immune modulation. In the field...
Expert Forum
A re-understanding of the physiological function of albumin
Jingjing WANG, Ligai LIU, Wen XIE
2025, 41(3): 404-408. DOI: 10.12449/JCH250302
Abstract(52) HTML (17) PDF (580KB)(19)
Abstract:
As an important protein synthesized by the liver， albumin is one of the most important markers for liver function， and its structure and function change with the progression of liver injury. Latest studies have shown that albumin in the disease state is not only reduced in quantity， but also damaged...
The application of human serum albumin in liver cirrhosis and its complications
Yaxin LI, Huiguo DING
2025, 41(3): 409-414. DOI: 10.12449/JCH250303
Abstract(59) HTML (14) PDF (607KB)(14)
Abstract:
Albumin is synthesized in the liver， and in case of severe liver injury， albumin synthesis is reduced with structural alterations （such as an increase in methylation and glycosylation）， leading to a significant reduction in effective albumin in circulation. Albumin not only maintains plasma oncotic ...
The development and application of genetically engineered human serum albumin
Yanhang GAO, Junqi NIU
2025, 41(3): 415-419. DOI: 10.12449/JCH250304
Abstract(33) HTML (12) PDF (600KB)(11)
Abstract:
Human serum albumin （HSA） is the most abundant protein in plasma and has many biological functions and clinical applications. An adequate and stable supply of functional HSA molecules that are easy to store and have a long half-life is still an unmet clinical need. Therefore， it is extremely necessa...
Statistical considerations in the design of albumin clinical trials
Yuanyuan KONG, Chen YAO, Jidong JIA
2025, 41(3): 420-423. DOI: 10.12449/JCH250305
Abstract(36) HTML (12) PDF (496KB)(12)
Abstract:
Albumin is widely used in clinical practice， and the rationality of trial design directly affects the reliability of research findings and clinical application value. This article reviews the key statistical considerations in the design of albumin clinical trials， including the selection of primary ...
Guideline
Guidelines for fecal microbiota transplantation therapy in patients with liver cirrhosis
Viral Hepatitis Group of Professional Committee of Liver Disease （combined traditional Chinese and western medicine） of Chinese Research Hospital Association, Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases
2025, 41(3): 424-431. DOI: 10.12449/JCH250306
Abstract(44) HTML (21) PDF (979KB)(14)
Abstract:
Expert consensus on precision detection of intrahepatic cholangiocarcinoma （2024 edition）
Pathology Group, Chinese Society of Liver Cancer of Chinese Anti-Cancer Association, Liver Pathology Group
2025, 41(3): 432-441. DOI: 10.12449/JCH250307
Abstract(42) HTML (21) PDF (1128KB)(12)
Abstract:
Intrahepatic cholangiocarcinoma （ICC） is a highly heterogeneous tumor， and molecular profiling serves as the foundation for personalized treatment of ICC. Accurate detection methods are clinically significant for comprehensively screening patients suitable for targeted therapies. This consensus is b...
Guideline Interpretation
Interpretation of metabolic dysfunction and alcohol-related liver disease： Position statement by an expert panel on alcohol-related liver disease （2024 edition）
Zhenyao JIANG, Binbin ZHANG, Jie LI, Junping SHI
2025, 41(3): 442-445. DOI: 10.12449/JCH250308
Abstract(38) HTML (17) PDF (575KB)(10)
Abstract:
In November 2024， the Expert Group on Alcohol-related Liver Disease released a position statement on metabolic dysfunction and alcohol-related liver disease （MetALD）. MetALD is a new subtype of steatotic liver disease and refers to MASLD patients with a relatively large amount of alcohol consumption...
Fatty Liver Disease
Quality assessment of guidelines/consensuses on traditional Chinese medicine/integrated traditional Chinese and Western medicine diagnosis and treatment of nonalcoholic fatty liver disease
Ruimin JIAO, Jingjie ZHAO, Juanjuan LI, Wei CHEN, Chaoru HAN, Li LI, Chunjun XU, Hong YOU
2025, 41(3): 446-452. DOI: 10.12449/JCH250309
Abstract(41) HTML (14) PDF (936KB)(8)
Abstract:
Objective To evaluate the methodological quality and reporting quality of published guidelines/consensuses on traditional Chinese medicine （TCM）/integrated traditional Chinese and Western medicine diagnosis and treatment of nonalcoholic fatty liver disease （NAFLD）， and to provide a basis for formula...
Diagnostic value of miR-128-3p， SIRT1， and AMPK in patients with type 2 diabetes mellitus comorbid with nonalcoholic fatty liver disease
Juyi LI, Yingqun NI, Yuanyuan ZHANG, Huaizhen LIU
2025, 41(3): 453-460. DOI: 10.12449/JCH250310
Abstract(33) HTML (12) PDF (1188KB)(7)
Abstract:
Objective To investigate the expression levels of miR-128-3p， SIRT1， and AMPK in the peripheral blood of patients with type 2 diabetes mellitus （T2DM） comorbid with nonalcoholic fatty liver disease （NAFLD）， as well as the role of miR-128-3p in predicting NAFLD in T2DM patients. Methods A total of 80...
Characteristics of T cells in the liver tissues of mice with nonalcoholic steatohepatitis
Ting MAO, Mingyi XU, Jiayi WANG
2025, 41(3): 461-468. DOI: 10.12449/JCH250311
Abstract(37) HTML (13) PDF (3813KB)(6)
Abstract:
Objective To investigate the heterogeneity and transcriptomic characteristics of T-cell subsets in the liver of mice with nonalcoholic steatohepatitis （NASH） at the single-cell level using single-cell RNA sequencing （scRNA-seq）， and to provide a reference for studying the mechanism of action of T ce...
Liver Fibrosis and Liver Cirrhosis
Effect of Yiqi Yangyin Jiedu Huayu prescription on intestinal metabolites in liver cirrhosis with minimal hepatic encephalopathy： A study based on metabolomics
Tingting JIANG, Qun ZHANG, Xianbo WANG, Yuyong JIANG, Xiaoli LIU, Hao YU, Zhiyun YANG
2025, 41(3): 469-477. DOI: 10.12449/JCH250312
Abstract(36) HTML (14) PDF (5152KB)(6)
Abstract:
Objective To investigate the effect of Yiqi Yangyin Jiedu Huayu prescription on minimal hepatic encephalopathy in liver cirrhosis based on intestinal metabolomics. Methods A total of 11 patients with liver cirrhosis who were hospitalized in Beijing Ditan Hospital， Capital Medical University， from Ma...
Liver Neoplasm
Effect of the nitroglycerin-controlled low central venous pressure technique on cerebral metabolic markers and cerebral blood oxygen saturation in patients undergoing laparoscopic hepatectomy for liver cancer
Bo WANG, Xia FU, Conghai LYU, Chunfang YIN, Qiyuan WU
2025, 41(3): 478-484. DOI: 10.12449/JCH250313
Abstract(33) HTML (11) PDF (743KB)(6)
Abstract:
Objective To investigate the effect of the nitroglycerin-controlled low central venous pressure （CLCVP） technique on brain metabolic markers and cerebral blood oxygen saturation in patients undergoing laparoscopic hepatectomy for liver cancer， and to reduce the risk of neurological complications. Me...
Effect of Go-Ichi-Ni-San complex subunit 1 on disease progression and chemotherapy resistance in hepatocellular carcinoma
Yishan HUO, Dawei LI, Xiangbing DUAN, Yuyu MA, Guojun ZHANG, Kainan ZHANG, Xiumin MA
2025, 41(3): 485-492. DOI: 10.12449/JCH250314
Abstract(28) HTML (12) PDF (3409KB)(4)
Abstract:
Objective To investigate the role and mechanism of Go-Ichi-Ni-San complex subunit 1 （GINS1） in the progression of hepatocellular carcinoma （HCC） and the development of chemotherapy resistance. Methods The tumor database GEPIA2 was used to analyze the differential expression of GINS1 between HCC pati...
Effect and mechanism of gallic acid on the proliferation， migration， invasion， and apoptosis of human hepatocellular carcinoma HepG2 cells
Zhiru WANG, Wenjing ZHAO, Xi CHEN
2025, 41(3): 493-498. DOI: 10.12449/JCH250315
Abstract(31) HTML (9) PDF (3143KB)(4)
Abstract:
Objective To investigate the effect of gallic acid （GA） on the proliferation， migration， invasion， and apoptosis of human hepatocellular carcinoma HepG2 cells and its mechanism. Methods HepG2 cells were treated with different concentrations of GA （0， 5， 10， 20， 30， 40， and 50 μg/mL） for 24 and 48 ho...
Study on the protective efect and mechanism of paeoniflorin on palmitic acid-induced HepG2 cells
Tong LIU, Shanzheng LI, Cheng ZHOU, Sutong LIU, Lihui ZHANG, Wenxia ZHAO
2025, 41(3): 499-505. DOI: 10.12449/JCH250316
Abstract(33) HTML (16) PDF (2930KB)(4)
Abstract:
Objective To investigate the role and mechanism of action of paeoniflorin （PF） in protecting HepG2 cells induced by palmitic acid （PA）. Methods HepG2 cells were stimulated with PA at a concentration of 250 μmol/L to establish a NAFLD model. Compound C at a concentration of 10 μmol/L was used as an i...
Other Liver Disease
Influencing factors for meropenem-related liver injury and their predictive value
Yan HE, Hongqin KE, Hongliang LI, Jianyong ZHU, Lijun ZHAO, Huibin YU
2025, 41(3): 506-512. DOI: 10.12449/JCH250317
Abstract(43) HTML (24) PDF (1170KB)(7)
Abstract:
Objective To analyze the factors influencing meropenem-related liver injury （MRLI） and to explore their clinical predictive value. Methods A retrospective case-control study was conducted， and the Chinese Hospital Pharmacovigilance System （CHPS） was used to establish a retrieval scheme. A total of 1...
Biliary Disease
Efficacy and safety of endoscopic retrograde cholangiopancreatography combined with oral cholangiopancreatography in the treatment of duodenal papilla cholecystectomy
Liying TAO, Hongguang WANG, Qingmei GUO, Xiang GUO, Lianyu PIAO, Muyu YANG, Yong YU, Libin RUAN, Jianbin GU, Si CHEN, Yingting DU, Xiuying GAI, Sijie GUO
2025, 41(3): 513-517. DOI: 10.12449/JCH250318
Abstract(39) HTML (14) PDF (1711KB)(5)
Abstract:
Objective To investigate the feasibility and safety of endoscopic retrograde cholangiopancreatography （ERCP） combined with oral cholangiopancreatography in the treatment of major duodenal papilla gallbladder polyps. Methods A retrospective analysis was performed for the clinical data of eight patien...
Development of a predictive model and application for spontaneous passage of common bile duct stones based on automated machine learning
Jian CHEN, Kaijian XIA, Fuli GAO, Luojie LIU, Ganhong WANG, Xiaodan XU
2025, 41(3): 518-527. DOI: 10.12449/JCH250319
Abstract(40) HTML (21) PDF (3367KB)(10)
Abstract:
Objective To develop a predictive model and application for spontaneous passage of common bile duct stones using automated machine learning algorithms given the complexity of treatment decision-making for patients with common bile duct stones， and to reduce unnecessary endoscopic retrograde cholangi...
Pancreatic Disease
Distribution pattern of traditional Chinese medicine syndromes and analysis of influencing factors in pancreatic cancer
Zhiyao SHI, Shiyu WU, Shaojian REN, Yichan LIU, Yijie YIN, Yu GAO, Xixing WANG
2025, 41(3): 528-535. DOI: 10.12449/JCH250320
Abstract(37) HTML (18) PDF (750KB)(4)
Abstract:
Objective To investigate the influencing factors for traditional Chinese medicine （TCM） syndromes in pancreatic cancer by analyzing 608 cases， and to provide a theoretical reference for TCM syndrome differentiation and standardized treatment of pancreatic cancer. Methods A total of 608 patients with...
Case Report
Rare giant hepatic angiomyolipoma with subcapsular rupture misdiagnosed as hepatocellular carcinoma： A case report
Zhiwei ZHANG, Feng LIU, Hezhao ZHANG, Qinying WANG, Zhiyong SHI
2025, 41(3): 536-541. DOI: 10.12449/JCH250321
Abstract(37) HTML (12) PDF (3282KB)(6)
Abstract:
Hepatic angiomyolipoma （HAML） is a rare benign mesenchymal tumor frequently observed in middle-aged women. Due to the absence of prominent symptoms in the early stage and the lack of specific imaging findings， the diagnosis of this disease can be challenging， leading to a high rate of misdiagnosis. ...
Review
Clinical diagnosis of drug-induced autoimmune-like hepatitis
Yongping LIU, Yaojie SHEN
2025, 41(3): 542-546. DOI: 10.12449/JCH250322
Abstract(41) HTML (17) PDF (640KB)(9)
Abstract:
Some patients with drug-induced liver injury （DILI） may present with similar features to patients with autoimmune hepatitis （AIH）， and such cases are defined as drug-induced autoimmune-like hepatitis （DI-ALH）. In 2022， the European Association for the Study of the Liver discussed the nomenclature， d...
Role of amino acid metabolism in autoimmune hepatitis and related therapeutic targets
Peipei GUO, Yang XU, Jiaqi SHI, Yang WU, Lixia LU, Bin LI, Xiaohui YU
2025, 41(3): 547-551. DOI: 10.12449/JCH250323
Abstract(33) HTML (14) PDF (595KB)(5)
Abstract:
Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease. The pathogenesis of AIH remains unclear， but it is mainly autoimmune injury caused by the breakdown of autoimmune tolerance due to the abnormal activation of the immune system， while the specific molecular mechanism remains unknown....
Gut microbiota in hepatitis B cirrhosis
Yannan LI, Changzheng LI
2025, 41(3): 552-555. DOI: 10.12449/JCH250324
Abstract(32) HTML (14) PDF (554KB)(5)
Abstract:
Hepatitis B cirrhosis is the most significant component of liver cirrhosis in China， and there is a significant increase in the mortality rate of patients after progression from hepatitis to liver cirrhosis. A large number of studies have shown that gut microbiota may influence the progression of he...
Application of Model for End-Stage Liver Disease score in end-stage liver disease
Rigan XIGU, Ya SU, Jing TONG, Bingyuan WANG
2025, 41(3): 556-560. DOI: 10.12449/JCH250325
Abstract(30) HTML (11) PDF (583KB)(5)
Abstract:
The Model for End-Stage Liver Disease （MELD） score is currently used to prioritize liver allocation for cirrhotic patients awaiting liver transplantation in the world. With the application of MELD score in transplantation for patients with severe conditions， several models have been proposed to refi...
Influencing factors for the homing ability of mesenchymal stem cells in end-stage liver disease and optimization measures
Yuxin LIU, Liaoyun ZHANG
2025, 41(3): 561-567. DOI: 10.12449/JCH250326
Abstract(33) HTML (16) PDF (761KB)(3)
Abstract:
Mesenchymal stem cells （MSCs） have emerged as a promising cellular therapy for end-stage liver disease （ESLD） due to their robust self-regenerative， paracrine， and immunomodulatory characteristics， providing new directions for the treatment of advanced liver disease. However， the clinical applicatio...
Effect of intestinal flora and metabolites on the development and progression of acute-on-chronic liver failure
Ke SHI, Qun ZHANG, Xianbo WANG, Ying FENG
2025, 41(3): 568-573. DOI: 10.12449/JCH250327
Abstract(32) HTML (14) PDF (680KB)(6)
Abstract:
Acute-on-chronic liver failure （ACLF） is a dangerous disease with severe conditions， rapid progression， and high short-term mortality. Intestinal flora and metabolites are closely associated with the development， progression， and pathogenesis of ACLF. During the development of ACLF， the destruction ...
Association between intestinal barrier disruption in liver failure and the cGAS-STING signaling pathway
Qiao TANG, Chao ZHOU, Ning ZHANG, Man GONG
2025, 41(3): 574-579. DOI: 10.12449/JCH250328
Abstract(31) HTML (12) PDF (937KB)(4)
Abstract:
Liver failure is a common severe syndrome of liver diseases with high mortality. The function and structural integrity of the intestinal barrier as an entity are closely associated with the development and progression of liver failure. The cGAS-STING signaling pathway can participate in innate immun...
Risk factors， diagnosis and treatment of perforation after endoscopic retrograde cholangiopancreatography
Wenyu ZHAO, Yan FU, Yajiao DUAN, Juan TANG, Jing NI
2025, 41(3): 580-587. DOI: 10.12449/JCH250329
Abstract(29) HTML (10) PDF (806KB)(4)
Abstract:
After 50 years of clinical development， endoscopic retrograde cholangiopancreatography （ERCP） has become the preferred method for the clinical diagnosis and treatment of cholangio-pancreatic duct diseases； however， the major postoperative complications of ERCP， such as pancreatitis， hemorrhage， and ...
Mechanism of action of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma
Xue YU, Tianhao SHEN, Cheng ZHOU, Yu LIU, Wei LI, Tinghui JIANG, Yongqiang ZHU, Yan LIU
2025, 41(3): 588-593. DOI: 10.12449/JCH250330
Abstract(33) HTML (15) PDF (1044KB)(4)
Abstract:
Intrahepatic cholangiocarcinoma is a malignant tumor with an extremely poor prognosis， and its pathogenesis is complex and remains unclear. In recent years， more and more studies have focused on the role of bile-gut axis in the development and progression of intrahepatic cholangiocarcinoma. Bile-gut...
Components of tumor stroma-immune microenvironment and their interactions in intrahepatic cholangiocarcinoma
Qiulu ZHANG, Zhuo LI, Congrong LIU, Limei GUO
2025, 41(3): 594-600. DOI: 10.12449/JCH250331
Abstract(35) HTML (17) PDF (1621KB)(4)
Abstract:
Intrahepatic cholangiocarcinoma （ICC） is a highly malignant liver tumor， and due to the absence of symptoms in its early stage and the lack of effective treatment measures， patients tend to have an extremely low 5-year survival rate. The tumor stroma-immune microenvironment （TSIME） is a complex ecos...
Introduction of High - quality Articles in Foreign Journals
Gut｜E-twenty-six-specific sequence variant 5 (ETV5) facilitates hepatocellular carcinoma progression and metastasis through enhancing polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC)-mediated immunosuppression
2025, 41(3): 484-484. DOI: 10.12449/JCH2503.gwqkjpwzjj1
Abstract(33) HTML (10) PDF (891KB)(6)
Abstract:
Hepatology International｜Non-canonical Wnt signaling pathway activated NFATC3 promotes GDF15 expression in MASH: prospective analyses of UK biobank proteomic data
2025, 41(3): 541-541. DOI: 10.12449/JCH2503.gwqkjpwzjj2
Abstract(27) HTML (13) PDF (904KB)(3)
Abstract:
Hepatology｜Genomic and the tumor microenvironment heterogeneity in multifocal hepatocellular carcinoma
2025, 41(3): 546-546. DOI: 10.12449/JCH2503.gwqkjpwzjj3
Abstract(28) HTML (10) PDF (891KB)(3)
Abstract:
Hepatology International｜Global, regional, and national burden of liver cancer due to non-alcoholic steatohepatitis and non-alcoholic fatty liver disease, 1990—2021: a multi-model trend analysis and forecasting study
2025, 41(3): 567-567. DOI: 10.12449/JCH2503.gwqkjpwzjj4
Abstract(28) HTML (10) PDF (888KB)(4)
Abstract:
Journal of Hepatology｜TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway
2025, 41(3): 587-587. DOI: 10.12449/JCH2503.gwqkjpwzjj5
Abstract(25) HTML (16) PDF (903KB)(3)
Abstract:
Acknowledgements
Current reviewers
2025, 41(3): 306-306. DOI: 10.12449/JCH2503.zhixie
Abstract(31) HTML (11) PDF (1045KB)(2)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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