Advances in the application of direct-acting antivirals in patients with hepatitis C cirrhosis

Xiping RAN; Dachuan CAI

doi:10.12449/JCH240828

Volume 40 Issue 8

Aug. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(8): 1682-1687

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Advances in the application of direct-acting antivirals in patients with hepatitis C cirrhosis

DOI: 10.12449/JCH240828

Xiping RAN¹,
Dachuan CAI^{2
,
,
,}

1.
Department of Infectious Diseases，The Second Affiliated Hospital of Chongqing Medical University，Chongqing 401336，China
2.
Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education，Institute for Viral Hepatitis，Chongqing Medical University，Chongqing 400010，China

Research funding:

Chongqing Medical Scientific Research Key Project （Joint Project of Chongqing Health Commission and Science and Technology Bureau） (2022ZDXM001);

The First Batch of Key Disciplines on Public Health in Chongqing

More Information

Corresponding author: CAI Dachuan， cqmucdc@cqmu.edu.cn （ORCID： 0000-0003-3269-8549）
Received Date: 2023-12-12
Accepted Date: 2024-01-12
Published Date: 2024-08-25

Abstract

Abstract

Chronic hepatitis C virus （HCV） infection can lead to liver cirrhosis， and complications after liver cirrhosis， including hepatocellular carcinoma （HCC）， are the leading causes of death in patients with chronic liver diseases. Antiviral therapy can help to realize sustained virologic response， improve hepatitis and liver fibrosis， and delay disease progression. The safety and efficacy of direct-acting antivirals （DAAs） have been confirmed in patients with HCV-related liver cirrhosis， and whether DAAs can improve the complications and prognosis of patients with liver cirrhosis has gradually become a research hotspot. Related data are mainly reported by foreign scholars， and since DAAs have not been marketed in China for a long time， there is still a lack of mid- and long-term data. This article reviews the latest studies on the application of DAAs in patients with HCV-related liver cirrhosis and the impact of DAAs on clinical prognosis.
- Hepacivirus,
- Liver Cirrhosis,
- Direct-Acting Antivirals,
- Treatment Outcome

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References(45)

References

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Advances in the application of direct-acting antivirals in patients with hepatitis C cirrhosis

DOI: 10.12449/JCH240828

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