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CN 22-1108/R
Volume 40 Issue 8
Aug.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(8): 1639-1645

Value of urinary liver fatty acid-binding protein in predicting the short-term prognosis of patients with acute-on-chronic liver failure

DOI: 10.12449/JCH240821
  • 1.

    Department of Hepatology Unit and Infectious Diseases，Nanfang Hospital，Southern Medical University，Guangzhou 510515，China

  • 2.

    Hepatology Unit，Zengcheng Branch，Nanfang Hospital，Southern Medical University，Guangzhou 511300，China

  • 3.

    State Key Laboratory of Organ Failure Research，Guangzhou 510515，China

  • 4.

    Guangdong Provincial Key Laboratory of Viral Hepatitis Research，Guangzhou 510515，China

  • 5.

    Key Laboratory of Infectious Diseases Research in South China，Ministry of Education，Guangzhou 510515，China

Research funding:

National Key Research and Development Program of China (2022YFC2304800);

National Natural Science Foundation of China (82370614);

National Natural Science Foundation of China (82070650);

National Science and Technology Major Project (2018ZX10723203);

Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01S131);

Clinical Research Program of Nanfang Hospital, Southern Medical University (2018CR037);

Clinical Research Program of Nanfang Hospital, Southern Medical University (2020CR026);

Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education (LC2019ZD006);

President Foundation of Nanfang Hospital, Southern Medical University (2019Z003);

Key-Area Research and Development Program of Guangdong Province (2019B020227004)

More Information
  • Corresponding author: CHEN Jinjun， chjj@smu.edu.cn （ORCID： 0000-0003-4275-9149）
  • Received Date: 2024-02-20
  • Accepted Date: 2024-05-28
  • Published Date: 2024-08-25
    Abstract
  •   Objective  To investigate the value of liver fatty acid-binding protein （L-FABP） in predicting the severity and short-term prognosis of patients with acute-on-chronic liver failure （ACLF）.  Methods  A total of 149 patients with ACLF were selected from a prospective multicenter cohort assessing the platelet function of ACLF patients， and according to the 28-day prognosis after admission， they were divided into survival group with 97 patients and death group with 52 patients. The patients were analyzed in terms of sex， age， etiology， and blood routine， biochemical parameters， and organ failure status within 24 hours after admission， and the level of L-FABP in urine and blood was measured. The independent-samples t test was used for comparison of normally distributed continuous data between two groups， and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups； the chi-square test was used for comparison of categorical data between two groups. The Spearman test was used to evaluate the correlation between urinary L-FABP and indicators for liver failure. The receiver operating characteristic （ROC） curve was plotted to assess the value of CLIF-OFs， MELD score， and urinary L-FABP in predicting the short-term prognosis of ACLF patients； the Kaplan-Meier analysis was used to evaluate short-term mortality in the high urinary L-FABP group and the low urinary L-FABP group； the Cox proportional hazards model was used to investigate the association of each factor with the short-term prognosis of ACLF.  Results  There were significant differences between the two groups in white blood cell count， serum total bilirubin （TBil）， international normalized ratio， CLIF-OFs， MELD score， urinary L-FABP level， and the proportion of patients with cerebral failure， liver failure， coagulation failure， renal failure， or respiratory failure （all P<0.05）. The Spearman correlation analysis showed that urinary L-FABP was significantly positively correlated with serum TBil （r=0.225， P=0.006）. Urinary L-FABP level had an area under the ROC curve of 0.804 （95% confidence interval ［CI］： 0.729 ‍—‍ 0.865， P<0.001） and a cut-off value of 4.779 µg/dL， with a sensitivity of 73.08%， a specificity of 73.91%， and a Youden index of 0.469 9. The Kaplan-Meier survival analysis showed that compared with the low urinary L-FABP group （urinary L-FABP≤4.779 µg/dL）， the high urinary L-FABP group （urinary L-FABP>4.779 µg/dL） had a significantly lower 28-day survival rate （P<0.001）. The Cox proportional hazards model analysis showed that serum TBil （hazard ratio ［HR］=1.003， 95%CI： 1.001‍‍ —‍ ‍1.004， P<0.05）， CLIF-OFs （HR=2.283， 95%CI： 1.814 — 2.873， P<0.05）， and high urinary L-FABP level （HR=4.568， 95%CI： 2.424 — 8.608， P<0.05） were independent risk factors for the short-term prognosis of ACLF.  Conclusion  High urinary L-FABP level can be used as a clinical indicator for predicting the short-term prognosis of ACLF， and further studies with larger sample sizes are needed to evaluate its predictive value.

     

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    • References(21)
  • [1]
    ZHANG Q, HAN T. Prognostic evaluation of acute-on-chronic liver failure[J]. J Clin Hepatol, 2023, 39( 10): 2301- 2306. DOI: 10.3969/j.issn.1001-5256.2023.10.006.

    张倩, 韩涛. 慢加急性肝衰竭的预后评价[J]. 临床肝胆病杂志, 2023, 39( 10): 2301- 2306. DOI: 10.3969/j.issn.1001-5256.2023.10.006.
    [2]
    EGUCHI A, IWASA M. The role of elevated liver-type fatty acid-binding proteins in liver diseases[J]. Pharm Res, 2021, 38( 1): 89- 95. DOI: 10.1007/s11095-021-02998-x.
    [3]
    WANG NN, XU LZ, WANG YP. Progress in liver type fatty acid binding protein[J]. Chin Bull Life Sci, 2012, 24( 2): 139- 144. DOI: 10.13376/j.cbls/2012.02.002.

    王南南, 徐力致, 王亚平. 肝型脂肪酸结合蛋白研究进展[J]. 生命科学, 2012, 24( 2): 139- 144. DOI: 10.13376/j.cbls/2012.02.002.
    [4]
    WEN YM, PARIKH CR. Current concepts and advances in biomarkers of acute kidney injury[J]. Crit Rev Clin Lab Sci, 2021, 58( 5): 354- 368. DOI: 10.1080/10408363.2021.1879000.
    [5]
    PRIYADARSHINI G, RAJAPPA M. Predictive markers in chronic kidney disease[J]. Clin Chim Acta, 2022, 535: 180- 186. DOI: 10.1016/j.cca.2022.08.018.
    [6]
    JUANOLA A, GRAUPERA I, ELIA C, et al. Urinary L-FABP is a promising prognostic biomarker of ACLF and mortality in patients with decompensated cirrhosis[J]. J Hepatol, 2022, 76( 1): 107- 114. DOI: 10.1016/j.jhep.2021.08.031.
    [7]
    JIANG XH, CHAI SQ, HUANG Y, et al. Design for a multicentre prospective cohort for the assessment of platelet function in patients with hepatitis-B-virus-related acute-on-chronic liver failure[J]. Clin Epidemiol, 2022, 14: 997- 1011. DOI: 10.2147/CLEP.S376068.
    [8]
    SARIN SK, CHOUDHURY A, SHARMA MK, et al. Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific association for the study of the liver(APASL): An update[J]. Hepatol Int, 2019, 13( 4): 353- 390. DOI: 10.1007/s12072-019-09946-3.
    [9]
    European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis[J]. J Hepatol, 2018, 69( 2): 406- 460. DOI: 10.1016/j.jhep.2018.03.024.
    [10]
    ANGELI P, GINÈS P, WONG F, et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: Revised consensus recommendations of the International Club of Ascites[J]. J Hepatol, 2015, 62( 4): 968- 974. DOI: 10.1016/j.jhep.2014.12.029.
    [11]
    BLEI AT, CÓRDOBA J. Hepatic encephalopathy[J]. Am J Gastroenterol, 2001, 96( 7): 1968- 1976. DOI: 10.1111/j.1572-0241.2001.03964.x.
    [12]
    KULKARNI AV, SHARMA M, KUMAR P, et al. Adipocyte fatty acid-binding protein as a predictor of outcome in alcohol-induced acute-on-chronic liver failure[J]. J Clin Exp Hepatol, 2021, 11( 2): 201- 208. DOI: 10.1016/j.jceh.2020.07.010.
    [13]
    CHEN AP, TANG YC, DAVIS V, et al. Liver fatty acid binding protein(L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease[J]. Hepatology, 2013, 57( 6): 2202- 2212. DOI: 10.1002/hep.26318.
    [14]
    LIN JG, ZHENG SZ, ATTIE AD, et al. Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells[J]. J Lipid Res, 2018, 59( 3): 416- 428. DOI: 10.1194/jlr.M077487.
    [15]
    PAWLAK M, LEFEBVRE P, STAELS B. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease[J]. J Hepatol, 2015, 62( 3): 720- 733. DOI: 10.1016/j.jhep.2014.10.039.
    [16]
    LÓPEZ-VICARIO C, CHECA A, URDANGARIN A, et al. Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis[J]. J Hepatol, 2020, 73( 4): 817- 828. DOI: 10.1016/j.jhep.2020.03.046.
    [17]
    ZHANG Y, LIU KC, HASSAN HM, et al. Liver fatty acid binding protein deficiency provokes oxidative stress, inflammation, and apoptosis-mediated hepatotoxicity induced by pyrazinamide in zebrafish larvae[J]. Antimicrob Agents Chemother, 2016, 60( 12): 7347- 7356. DOI: 10.1128/AAC.01693-16.
    [18]
    VOTH M, VERBOKET R, HENRICH D, et al. L-FABP and NGAL are novel biomarkers for detection of abdominal injury and hemorrhagic shock[J]. Injury, 2023, 54( 5): 1246- 1256. DOI: 10.1016/j.injury.2023.01.001.
    [19]
    LI Q, WANG J, LU MJ, et al. Acute-on-chronic liver failure from chronic-hepatitis-B, who is the behind scenes[J]. Front Microbiol, 2020, 11: 583423. DOI: 10.3389/fmicb.2020.583423.
    [20]
    EGUCHI A, HASEGAWA H, IWASA M, et al. Serum liver-type fatty acid-binding protein is a possible prognostic factor in human chronic liver diseases from chronic hepatitis to liver cirrhosis and hepatocellular carcinoma[J]. Hepatol Commun, 2019, 3( 6): 825- 837. DOI: 10.1002/hep4.1350.
    [21]
    MCMAHON BA, MURRAY PT. Urinary liver fatty acid-binding protein: Another novel biomarker of acute kidney injury[J]. Kidney Int, 2010, 77( 8): 657- 659. DOI: 10.1038/ki.2010.5.
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