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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 8
Aug.  2024
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Article Contents

Diagnosis of herb-induced liver injury: Challenges in practice

DOI: 10.12449/JCH240805
Research funding:

National Key Research and Development Program of China (2022YFC35022101);

National Science and Technology Major Project during the 13th Five Year Plan Period (2017ZX09304016);

National Natural Science Foundation of China (81970513);

National Natural Science Foundation of China (82270619)

More Information
  • Corresponding author: TANG Jieting, start_tjt@msn.com (ORCID: 0000-0002-6048-9173); MAO Yimin, maoym11968@163.com (ORCID: 0000-0002-2928-3425)
  • Received Date: 2024-07-01
  • Accepted Date: 2024-07-13
  • Published Date: 2024-08-25
  • With the increasingly wide application of herbal medicines and dietary supplements worldwide, herb-induced liver injury (HILI) has become an important etiology of drug-induced liver injury. Due to the diverse manifestations of HILI, the difficulty in medical history collection, and the lack of specific biomarkers, how to identify suspected patients and make a correct diagnosis has become a major challenge in practice. Causality assessment is commonly used in the diagnosis of HILI, but there is still a lack of prospective cohort studies with a large sample size. In addition, further studies are needed to search for the specific biomarkers for the diagnosis of HILI. The diagnosis and differential diagnosis of HILI are challenging, and currently there is still no universally accepted uniform and standard method for the diagnosis of all-cause HILI.

     

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