Diagnosis of herb-induced liver injury： Challenges in practice

Yinuo DONG; Yang ZHI; Jieting TANG; Yimin MAO

doi:10.12449/JCH240805

Volume 40 Issue 8

Aug. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(8): 1533-1537

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Diagnosis of herb-induced liver injury： Challenges in practice

DOI: 10.12449/JCH240805

Division of Gastroenterology and Hepatology，Renji Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai Institute of Digestive Disease，Shanghai Research Center for Diagnosis and Treatment of Fatty Liver Disease，Shanghai 200001，China

Research funding:

National Key Research and Development Program of China (2022YFC35022101);

National Science and Technology Major Project during the 13th Five Year Plan Period (2017ZX09304016);

National Natural Science Foundation of China (81970513);

National Natural Science Foundation of China (82270619)

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Corresponding author: TANG Jieting， start_tjt@msn.com （ORCID： 0000-0002-6048-9173）; MAO Yimin， maoym11968@163.com （ORCID： 0000-0002-2928-3425）
Received Date: 2024-07-01
Accepted Date: 2024-07-13
Published Date: 2024-08-25

Abstract

Abstract

With the increasingly wide application of herbal medicines and dietary supplements worldwide， herb-induced liver injury （HILI） has become an important etiology of drug-induced liver injury. Due to the diverse manifestations of HILI， the difficulty in medical history collection， and the lack of specific biomarkers， how to identify suspected patients and make a correct diagnosis has become a major challenge in practice. Causality assessment is commonly used in the diagnosis of HILI， but there is still a lack of prospective cohort studies with a large sample size. In addition， further studies are needed to search for the specific biomarkers for the diagnosis of HILI. The diagnosis and differential diagnosis of HILI are challenging， and currently there is still no universally accepted uniform and standard method for the diagnosis of all-cause HILI.
- Drugs， Chinese Herbal,
- Chemical and Drug Induced Liver Injury,
- Diagnosis,
- Causality Assessment,
- Biomarkers

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References(24)

References

[1]	DEVARBHAVI H, AITHAL G, TREEPRASERTSUK S, et al. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines[J]. Hepatol Int, 2021, 15( 2): 258- 282. DOI: 10.1007/s12072-021-10144-3.
[2]	Branch of Hepatobiliary Diseases, China Association of Chinese Medicine, Branch of Chinese Patent Medicine, China Association of Chinese Medicine. Guideline for diagnosis and treatment of herb-induced liver injury[J]. J Clin Hepatol, 2016, 32( 5): 835- 843. DOI: 10.3969/j.issn.1001-5256.2016.05.003. 中华中医药学会肝胆病分会, 中华中医药学会中成药分会. 中草药相关肝损伤临床诊疗指南[J]. 临床肝胆病杂志, 2016, 32( 5): 835- 843. DOI: 10.3969/j.issn.1001-5256.2016.05.003.
[3]	MAO Y, MA S, LIU C, et al. Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update[J]. Hepatol Int, 2024, 18( 2): 384- 419. DOI: 10.1007/s12072-023-10633-7.
[4]	Committee on DILI Prevention and Management, Chinese Medical Biotechnology Association; Study Group of Drug-Induced Liver Disease, Chinese Medical Association for the Study of Liver Diseases. Chinese guideline for diagnosis and management of drug-induced liver injury(2023 version)[J].[J]. Chin J Gastroenterol, 2023, 28( 7): 397- 431. DOI: 10.3760/cma.j.cn501113-20230419-00176. 中国医药生物技术协会药物性肝损伤防治技术专业委员会, 中华医学会肝病学分会药物性肝病学组. 中国药物性肝损伤诊治指南(2023年版)[J]. 胃肠病学, 2023, 28( 7): 397- 431. DOI: 10.3760/cma.j.cn501113-20230419-00176.
[5]	NUNES DRDCMA, MONTEIRO CSJ, DOS SANTOS JL. Herb-induced liver injury-a challenging diagnosis[J]. Healthcare(Basel), 2022, 10( 2): 278. DOI: 10.3390/healthcare10020278.
[6]	LARREY D, VIAL T, PAUWELS A, et al. Hepatitis after germander(Teucrium chamaedrys) administration: Another instance of herbal medicine hepatotoxicity[J]. Ann Intern Med, 1992, 117( 2): 129- 132. DOI: 10.7326/0003-4819-117-2-129.
[7]	LIN G, WANG JY, LI N, et al. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum[J]. J Hepatol, 2011, 54( 4): 666- 673. DOI: 10.1016/j.jhep.2010.07.031.
[8]	GARCÍA-CORTÉS M, STEPHENS C, LUCENA MI, et al. Causality assessment methods in drug induced liver injury: Strengths and weaknesses[J]. J Hepatol, 2011, 55( 3): 683- 691. DOI: 10.1016/j.jhep.2011.02.007.
[9]	TESCHKE R, DANAN G. Worldwide use of RUCAM for causality assessment in 81, 856 idiosyncratic DILI and 14, 029 HILI cases published 1993-mid 2020: A comprehensive analysis[J]. Medicines(Basel), 2020, 7( 10): 62. DOI: 10.3390/medicines7100062.
[10]	TESCHKE R, ZHU Y, JING J. Herb-induced liver injury in Asia and current role of RUCAM for causality assessment in 11, 160 published cases[J]. J Clin Transl Hepatol, 2020, 8( 2): 200- 214. DOI: 10.14218/jcth.2020.00009.
[11]	KOTHADIA JP, KAMINSKI M, SAMANT H, et al. Hepatotoxicity associated with use of the weight loss supplement Garcinia cambogia: A case report and review of the literature[J]. Case Reports Hepatol, 2018, 2018: 6483605. DOI: 10.1155/2018/6483605.
[12]	SMITH RJ, BERTILONE C, ROBERTSON AG. Fulminant liver failure and transplantation after use of dietary supplements[J]. Med J Aust, 2016, 204( 1): 30- 32. DOI: 10.5694/mja15.00816.
[13]	LAUBE R, LIU K. An unwanted complement: Rare case of potential liver injury induced by an interaction between ginseng and atorvastatin[J]. Br J Clin Pharmacol, 2019, 85( 7): 1612- 1613. DOI: 10.1111/bcp.13927.
[14]	HAYASHI PH, LUCENA MI, FONTANA RJ, et al. A revised electronic version of RUCAM for the diagnosis of DILI[J]. Hepatology, 2022, 76( 1): 18- 31. DOI: 10.1002/hep.32327.
[15]	ZHAO XY, WANG Y, LAI RT, et al. Validation of the revised electronic version of RUCAM for diagnosis of DILI in Chinese patients[J]. Hepatol Commun, 2024, 8( 4): e0235. DOI: 10.1097/HC9.0000000000000235.
[16]	ROCKEY DC, SEEFF LB, ROCHON J, et al. Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment method[J]. Hepatology, 2010, 51( 6): 2117- 2126. DOI: 10.1002/hep.23577.
[17]	State Drug Administration. Technical guidelines for clinical evaluation of liver injury induced by traditional Chinese medicine[J]. J Clin Hepatol, 2018, 34( 7): 1403- 1409. DOI: 10.3969/j.issn.1001-5256.2018.07.008. 国家药品监督管理局. 中药药源性肝损伤临床评价技术指导原则[J]. 临床肝胆病杂志, 2018, 34( 7): 1403- 1409. DOI: 10.3969/j.issn.1001-5256.2018.07.008.
[18]	HE TT, LIANG QS, WANG LP, et al. Diagnostic values of integrated evidence chain, Roussel Uclaf Causality Assessment Method, and Structured Expert Opinion Process method for drug-induced liver injury[J]. J Clin Hepatol, 2022, 38( 1): 141- 147. DOI: 10.3969/j.issn.1001-5256.2022.01.022. 何婷婷, 梁庆升, 王丽苹, 等. 整合证据链、Roussel Uclaf因果关系评价法、结构化专家观点程序对药物性肝损伤的诊断效用分析[J]. 临床肝胆病杂志, 2022, 38( 1): 141- 147. DOI: 10.3969/j.issn.1001-5256.2022.01.022.
[19]	CHAU TN, CHEUNG WI, NGAN T, et al. Causality assessment of herb-induced liver injury using multidisciplinary approach and Roussel Uclaf Causality Assessment Method(RUCAM)[J]. Clin Toxicol(Phila), 2011, 49( 1): 34- 39. DOI: 10.3109/15563650.2010.537662.
[20]	HOOFNAGLE JH, BONKOVSKY HL, PHILLIPS EJ, et al. HLA-B*35:01 and green tea-induced liver injury[J]. Hepatology, 2021, 73( 6): 2484- 2493. DOI: 10.1002/hep.31538.
[21]	LI CP, RAO T, CHEN XP, et al. HLA-B*35:01 allele is a potential biomarker for predicting Polygonum multiflorum-induced liver injury in humans[J]. Hepatology, 2019, 70( 1): 346- 357. DOI: 10.1002/hep.30660.
[22]	SARGES P, STEINBERG JM, LEWIS JH. Drug-induced liver injury: Highlights from a review of the 2015 literature[J]. Drug Saf, 2016, 39( 9): 801- 821.
[23]	LEWIS PJ, DEAR J, PLATT V, SIMPSON KJ, et al. Circulating microRNAs as potential markers of human drug-induced liver injury[J]. Hepatology, 2011, 54( 5): 1767- 1776.
[24]	JIE Z, et al. Integrated expression profiles of mRNA and microRNA in the liver of Fructus Meliae Toosendan water extract injured mice[J]. Frontiers in Pharmacology, 2015, 6: 236. DOI: 10.3389/fphar.2015.00236.

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Diagnosis of herb-induced liver injury： Challenges in practice

DOI: 10.12449/JCH240805

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Diagnosis of herb-induced liver injury： Challenges in practice

DOI: 10.12449/JCH240805

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