中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 7
Jul.  2024
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(7): 1397-1403

Efficacy and safety of three-dimensional visualization technology in assisting ablation therapy for hepatocellular carcinoma： A Meta-analysis

DOI: 10.12449/JCH240718
  • a.

    Department of General Surgery (Hepatopancreatobiliary Surgery), Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

  • b.

    Academician (Expert) Workstation of Sichuan Province, Metabolic Hepatobiliary and Pancreatic Diseases Key Laboratory of Luzhou City, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China

Research funding:

Regional Innovation Cooperation Project of Sichuan Province (2023YFQ0101);

Key Research and Development Project of Sichuan Province (22ZDYF1898)

More Information
  • Corresponding author: YANG Xiaoli， 344920646@qq.com （ORCID： 0000-0001-9071-0097）
  • Received Date: 2023-10-17
  • Accepted Date: 2024-01-08
  • Published Date: 2024-07-25
    Abstract
  •   Objective  To systematically evaluate the efficacy and safety of three-dimensional visualization technology in assisting ablation therapy for hepatocellular carcinoma.  Methods  This study was conducted according to PRISMA guidelines， with a PROSPERO registration number of CRD42023488398. PubMed， Embase， Web of Science， the Cochrane Library， CNKI， Wanfang Data， VIP， and CBM were searched for Chinese and English articles on three-dimensional visualization technology in assisting ablation therapy for hepatocellular carcinoma published up to March 2023. After quality assessment and data extraction of the studies included， RevMan 5.4 software was used to perform the meta-analysis.  Results  A total of 11 studies were included， with 972 patients in total， among whom 447 underwent ablation assisted by three-dimensional visualization technology （3D group） and 525 underwent ablation assisted by traditional two-dimensional imaging technology （2D group）. The meta-analysis showed that compared with the 2D group， the 3D group had significantly higher success rate of first-time ablation treatment （odds ratio ［OR］=5.43， 95% confidence interval ［CI］： 2.64‍ ‍—‍ ‍11.18， P<0.001）， technical efficiency （OR=6.15， 95%CI： 3.23‍ ‍—‍ ‍11.70， P<0.001）， and complete ablation rate （OR=2.50， 95%CI： 1.08‍ ‍—‍ ‍5.78， P=0.03）， as well as significantly lower incidence rate of major complications （OR=0.45， 95%CI： 0.24‍ ‍—‍ ‍0.87， P=0.02）， local recurrence rate （OR=0.35， 95%CI： 0.17‍ ‍—‍ ‍0.72， P=0.004）， and local tumor progression rate （OR=0.29， 95%CI： 0.16‍ ‍—‍ ‍0.50， P<0.001）， while there was no significant difference in the incidence rate of mild complications between the two groups （P>0.05）.  Conclusion  Three-dimensional visualization technology is safe and feasible in assisting ablation therapy for hepatocellular carcinoma and can improve ablation rate and reduce the incidence rate of serious complications， local recurrence rate， and local tumor progression rate， thereby showing an important application value in clinical practice.

     

    • FullText(HTML)
  • loading
    • References(35)
  • [1]
    SUNG H, FERLAY J, SIEGEL RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71( 3): 209- 249. DOI: 10.3322/caac.21660.
    [2]
    General Office of National Health Commission. Standard for diagnosis and treatment of primary liver cancer(2022 edition)[J]. J Clin Hepatol, 2022, 38( 2): 288- 303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.

    国家卫生健康委办公厅. 原发性肝癌诊疗指南(2022年版)[J]. 临床肝胆病杂志, 2022, 38( 2): 288- 303. DOI: 10.3969/j.issn.1001-5256.2022.02.009.
    [3]
    NGUYEN QT, TSIEN RY. Fluorescence-guided surgery with live molecular navigation: A new cutting edge[J]. Nat Rev Cancer, 2013, 13( 9): 653- 662. DOI: 10.1038/nrc3566.
    [4]
    POMPILI M, SAVIANO A, de MATTHAEIS N, et al. Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ≤3 cm. Results of a multicenter Italian survey[J]. J Hepatol, 2013, 59( 1): 89- 97. DOI: 10.1016/j.jhep.2013.03.009.
    [5]
    LIVRAGHI T. Single HCC smaller than 2 cm: surgery or ablation: Interventional oncologist’s perspective[J]. J Hepatobiliary Pancreat Sci, 2010, 17( 4): 425- 429. DOI: 10.1007/s00534-009-0244-x.
    [6]
    FENG K, YAN J, LI XW, et al. A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma[J]. J Hepatol, 2012, 57( 4): 794- 802. DOI: 10.1016/j.jhep.2012.05.007.
    [7]
    SOLBIATI L, IERACE T, TONOLINI M, et al. Guidance and monitoring of radiofrequency liver tumor ablation with contrast-enhanced ultrasound[J]. Eur J Radiol, 2004, 51 Suppl: S19- S23. DOI: 10.1016/j.ejrad.2004.03.035.
    [8]
    Chinese Society of Digital Medicine, Chinese Medical Association; Chinese Society of Liver Cancer, Chinese Medical Doctor Association; Clinical Precision Medicine Committee of Chinese Medical Doctor Association, et al. Three-dimensional visualization and accurate diagnosis and treatment guidelines for complex liver tumors(2019 edition)[J]. Chin J Pract Surg, 2019, 39( 8): 766- 774. DOI: 10.19538/j.cjps.issn1005-2208.2019.08.02.

    中华医学会数字医学分会, 中国医师协会肝癌专业委员会, 中国医师协会临床精准医学专业委员会, 等. 复杂性肝脏肿瘤三维可视化精准诊治指南(2019版)[J]. 中国实用外科杂志, 2019, 39( 8): 766- 774. DOI: 10.19538/j.cjps.issn1005-2208.2019.08.02.
    [9]
    WANG C, HUANG Q, YANG J. Meta-analysis of application value of three-dimensional visualization technique in liver cancer surgery[J]. Chin J Gen Surg, 2020, 29( 1): 19- 26. DOI: 10.7659/j.issn.1005-6947.2020.01.003.

    王程, 黄强, 杨骥. 三维可视化技术在肝脏恶性肿瘤手术中应用价值Meta分析[J]. 中国普通外科杂志, 2020, 29( 1): 19- 26. DOI: 10.7659/j.issn.1005-6947.2020.01.003.
    [10]
    ZHANG DZ, LIANG WZ, ZHANG M, et al. Multiple antenna placement in microwave ablation assisted by a three-dimensional fusion image navigation system for hepatocellular carcinoma[J]. Int J Hyperthermia, 2019, 35( 1): 122- 132. DOI: 10.1080/02656736.2018.1484183.
    [11]
    AHMED M, SOLBIATI L, BRACE CL, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update[J]. Radiology, 2014, 273( 1): 241- 260. DOI: 10.1148/radiol.14132958.
    [12]
    DINDO D, DEMARTINES N, CLAVIEN PA. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey[J]. Ann Surg, 2004, 240( 2): 205- 213. DOI: 10.1097/01.sla.0000133083.54934.ae.
    [13]
    TANG YQ, JIANG P, SHI BY, et al. Three-dimensional reconstruction to improve the success rate in the first attempt of radiofrequency ablation for small hepatocellular carcinoma[J]. Chin J Hepatobiliary Surg, 2015, 21( 10): 664- 667. DOI: 10.3760/cma.j.issn.1007-8118.2015.10.005.

    唐云强, 江鹏, 石波云, 等. 三维重建在提高肝癌第一次射频消融治疗成功率的应用价值[J]. 中华肝胆外科杂志, 2015, 21( 10): 664- 667. DOI: 10.3760/cma.j.issn.1007-8118.2015.10.005.
    [14]
    JADAD AR, MOORE RA, CARROLL D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?[J]. Control Clin Trials, 1996, 17( 1): 1- 12. DOI: 10.1016/0197-2456(95)00134-4.
    [15]
    LUCHINI C, STUBBS B, SOLMI M, et al. Assessing the quality of studies in meta-analyses: Advantages and limitations of the Newcastle Ottawa Scale[J]. World J Meta Anal, 2017, 5( 4): 80. DOI: 10.13105/wjma.v5.i4.80.
    [16]
    LAN SR, XU JW, ZHANG YM, et al. Guidance of real-time contrast-enhanced ultrasonography and 3D ultrasound fusion imaging for ablation area in patients with primary liver cancer during microwave ablation therapy[J]. J Pract Hepatol, 2022, 25( 6): 889- 892. DOI: 10.3969/j.issn.1672-5069.2022.06.033.

    蓝思荣, 徐继威, 张耀明, 等. 实时超声造影与3D超声融合成像导航评估微波消融治疗原发性肝癌患者价值研究[J]. 实用肝脏病杂志, 2022, 25( 6): 889- 892. DOI: 10.3969/j.issn.1672-5069.2022.06.033.
    [17]
    ZHANG YY. To explore the clinical effect of microwave ablation guided by ultrasound combined with three-dimensional imaging technology in the treatment of large liver cancer[J]. Cap Food Med, 2018, 25( 17): 69. DOI: 10.3969/j.issn.1005-8257.2018.17.052.

    张艳云. 探讨超声联合三维影像技术引导微波消融治疗大肝癌的临床疗效[J]. 首都食品与医药, 2018, 25( 17): 69. DOI: 10.3969/j.issn.1005-8257.2018.17.052.
    [18]
    LIAO HW. Study on three-dimensional visualization technology in microwave ablation of liver cancer[J]. World Latest Med Inf, 2017, 17( 61): 46. DOI: 10.19613/j.cnki.1671-3141.2017.61.033.

    廖华为. 三维可视化技术在微波消融治疗肝癌中的研究[J]. 世界最新医学信息文摘, 2017, 17( 61): 46. DOI: 10.19613/j.cnki.1671-3141.2017.61.033.
    [19]
    HE R, JIA Z, JIANG L, et al. Application of the three-dimensional visualization ablation planning system in radiofrequency ablation for hepatocellular carcinoma[J]. J Clin Hepatol, 2022, 38( 9): 2046- 2052. DOI: 10.3969/j.issn.1001-5256.2022.09.019.

    赫嵘, 贾哲, 蒋力, 等. 三维可视化消融辅助系统在肝细胞癌射频消融术中的应用价值[J]. 临床肝胆病杂志, 2022, 38( 9): 2046- 2052. DOI: 10.3969/j.issn.1001-5256.2022.09.019.
    [20]
    HAN Y, LIU CB, LI J. Ultrasound-guided percutaneous microwave ablation assisted by three-dimensional visualization operative planning for liver cancer abutting diaphragmatic dome[J]. Chin J Gastroenterol Hepatol, 2021, 30( 11): 1256- 1261. DOI: 10.3969/j.issn.1006-5709.2021.11.011.

    韩玥, 刘春波, 李津. 三维可视化术前规划辅助超声引导下经皮微波消融治疗临近膈顶肝癌[J]. 胃肠病学和肝病学杂志, 2021, 30( 11): 1256- 1261. DOI: 10.3969/j.issn.1006-5709.2021.11.011.
    [21]
    ZHANG WW, WANG HG, SHI XJ, et al. Significance of three-dimensional reconstruction as a method of preoperative planning of laparoscopic radiofrequency ablation[J]. Chin J Surg, 2016, 54( 9): 692- 699. DOI: 10.3760/cma.j.issn.0529-5815.2016.09.009.

    张雯雯, 王宏光, 史宪杰, 等. 三维重建术前规划在腹腔镜超声引导的肝癌射频消融术中的应用探讨[J]. 中华外科杂志, 2016, 54( 9): 692- 699. DOI: 10.3760/cma.j.issn.0529-5815.2016.09.009.
    [22]
    WANG XD, ZHAO P. Comparison between two-dimensional and three-dimensional contrast-enhanced ultrasound radiofrequency ablation in application of hepatocellular carcinoma[J]. J Sun Yat Sen Univ Med Sci, 2014, 35( 4): 602- 606.

    王晓东, 赵萍. 二维与三维超声造影在原发性肝癌射频治疗中的应用比较[J]. 中山大学学报(医学科学版), 2014, 35( 4): 602- 606.
    [23]
    LIU FY, LIANG P, YU XL, et al. A three-dimensional visualisation preoperative treatment planning system in microwave ablation for liver cancer: A preliminary clinical application[J]. Int J Hyperthermia, 2013, 29( 7): 671- 677. DOI: 10.3109/02656736.2013.834383.
    [24]
    AN C, LI X, ZHANG M, et al. 3D visualization ablation planning system assisted microwave ablation for hepatocellular carcinoma(Diameter>3): A precise clinical application[J]. BMC Cancer, 2020, 20( 1): 44. DOI: 10.1186/s12885-020-6519-y.
    [25]
    LIANG P, WANG Y. Microwave ablation of hepatocellular carcinoma[J]. Oncology, 2007, 72( Suppl 1): 124- 131. DOI: 10.1159/000111718.
    [26]
    FENSTER A, SURRY K, SMITH W, et al. 3D ultrasound imaging: Applications in image-guided therapy and biopsy[J]. Comput Graph, 2002, 26( 4): 557- 568. DOI: 10.1016/s0097-8493(02)00101-2.
    [27]
    YUAN YC, YUAN XC, WANG Q, et al. Ultrasound-guided percutaneous microwave ablation assisted by three-dimensional planning system combined with transhepatic arterial chemoembolization for treating single large hepatocellular carcinoma: A primary study of survival[J/CD]. Chin J Med Ultrasound(Electronic Edition), 2020, 17( 4): 315- 319. DOI: 10.3877/cma.j.issn.1672-6448.2020.04.005.

    袁迎春, 袁晓春, 王琦, 等. 三维可视化术前规划系统辅助超声引导微波消融联合肝动脉化疗栓塞治疗大肝癌效果的初步研究[J/CD]. 中华医学超声杂志(电子版), 2020, 17( 4): 315- 319. DOI: 10.3877/cma.j.issn.1672-6448.2020.04.005.
    [28]
    ROBERTS DW, STROHBEHN JW, HATCH JF, et al. A frameless stereotaxic integration of computerized tomographic imaging and the operating microscope[J]. J Neurosurg, 1986, 65( 4): 545- 549. DOI: 10.3171/jns.1986.65.4.0545.
    [29]
    JIANG JH, PEI L, JIANG RY. Clinical efficacy and safety of 3D vascular reconstruction combined with 3D navigation in laparoscopic hepatectomy: Systematic review and meta-analysis[J]. J Gastrointest Oncol, 2022, 13( 3): 1215- 1223. DOI: 10.21037/jgo-22-198.
    [30]
    ZHAO QX, YU J, DONG LN, et al. Analysis of recurrent hepatocellular carcinoma treated by microwave ablation assisted by three-dimensional visualization[J]. Chin J Pract Surg, 2019, 39( 10): 1068- 1070, 1076. DOI: 10.19538/j.cjps.issn1005-2208.2019.10.18.

    赵勤显, 于杰, 董立男, 等. 三维可视化辅助经皮微波消融治疗复发性肝癌价值分析[J]. 中国实用外科杂志, 2019, 39( 10): 1068- 1070, 1076. DOI: 10.19538/j.cjps.issn1005-2208.2019.10.18.
    [31]
    BALE R, SCHULLIAN P, EBERLE G, et al. Stereotactic radiofrequency ablation of hepatocellular carcinoma: A histopathological study in explanted livers[J]. Hepatology, 2019, 70( 3): 840- 850. DOI: 10.1002/hep.30406.
    [32]
    LAIMER G, SCHULLIAN P, JASCHKE N, et al. Minimal ablative margin(MAM) assessment with image fusion: An independent predictor for local tumor progression in hepatocellular carcinoma after stereotactic radiofrequency ablation[J]. Eur Radiol, 2020, 30( 5): 2463- 2472. DOI: 10.1007/s00330-019-06609-7.
    [33]
    HOCQUELET A, TRILLAUD H, FRULIO N, et al. Three-dimensional measurement of hepatocellular carcinoma ablation zones and margins for predicting local tumor progression[J]. J Vasc Interv Radiol, 2016, 27( 7): 1038- 1045. DOI: 10.1016/j.jvir.2016.02.031.
    [34]
    PERRODIN S, LACHENMAYER A, MAURER M, et al. Percutaneous stereotactic image-guided microwave ablation for malignant liver lesions[J]. Sci Rep, 2019, 9( 1): 13836. DOI: 10.1038/s41598-019-50159-3.
    [35]
    LIANG P, DONG BW, YU XL, et al. Prognostic factors for survival in patients with hepatocellular carcinoma after percutaneous microwave ablation[J]. Radiology, 2005, 235( 1): 299- 307. DOI: 10.1148/radiol.2351031944.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(8)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (134) PDF downloads(29) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return