Research advances in liver cancer organoids

Li ZHAO; Ziqi GUO; Yong YANG; Hongxin YANG

doi:10.12449/JCH240730

Volume 40 Issue 7

Jul. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(7): 1486-1492

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Research advances in liver cancer organoids

DOI: 10.12449/JCH240730

Li ZHAO¹,
Ziqi GUO¹,
Yong YANG²,
Hongxin YANG^{1
,
,
,}

1.
Department of Cell Biology，Inner Mongolia Medical University，Hohhot 010110，China
2.
Department of Abdominal Oncology，Inner Mongolia Autonomous Region People’s Hospital，Hohhot 010017，China

Research funding:

National Natural Science Foundation of China (81960772);

Inner Mongolia Medical University Key Project (YKD2022ZD016);

Natural Science Foundation of Inner Mongolia Autonomous Region (2019MS08087);

Inner Mongolia Medical University Tumor Organoid Gene Editing Translational Medicine Science and Technology Innovation Team Project

More Information

Corresponding author: YANG Hongxin， hongxinydiy@sina.com （ORCID： 0000-0002-5097-3260）
Received Date: 2023-11-18
Accepted Date: 2024-02-27
Published Date: 2024-07-25

Abstract

Abstract

Organoids are a novel disease model that is self-assembled from stem cells or malignant tumors and is used in clinical research. They are similar to tissues and organs in the body and have partially functional 3D cell structures. There are two types of traditional models for liver cancer research， i.e.， in vivo models （animal models of liver cancer established by induction） and in vitro cell experiments using corresponding cell lines. Organoids have the advantages of the two types of traditional models and show unique advantages in tumor research. Traditional models cannot fully reflect the microenvironment of cells， which often leads to the inconsistency with clinical research findings， and the emergence of new research models provides a new direction for the research on liver cancer. This article reviews the research advances in liver cancer organoids， in order to provide a new perspective for future research on liver cancer.
- Liver Neoplasms,
- Organoids,
- Cell Culture Techniques

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References(70)

References

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Research advances in liver cancer organoids

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