Mechanism of action of sterol regulatory element-binding proteins in nonalcoholic fatty liver disease and related therapeutic targets

Anqi LI; Peiran ZHAO; Yuqiang ZHAO; Rui WANG; Jing YANG

doi:10.12449/JCH240726

Volume 40 Issue 7

Jul. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(7): 1459-1465

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Mechanism of action of sterol regulatory element-binding proteins in nonalcoholic fatty liver disease and related therapeutic targets

DOI: 10.12449/JCH240726

1.
College of Basic Medical Heilongjiang University of Chinese Medicine，Harbin 150040，China
2.
College of Pharmacy Heilongjiang University of Chinese Medicine，Harbin 150040，China

Research funding:

National Natural Science Foundation of China (81603418);

Heilongjiang Province Excellent Young Talents Program (2020YQ05)

More Information

Corresponding author: YANG Jing， yangjingdx@sina.com （ORCID： 0000-0003-4770-3515）
Received Date: 2023-10-23
Accepted Date: 2023-11-29
Published Date: 2024-07-25

Abstract

Abstract

Nonalcoholic fatty liver disease （NAFLD） has become the most common liver disease in the world and is an important risk factor for the progression to hepatocellular carcinoma. However， the pathogenesis of NAFLD remains unclear， and there is still a lack of specific treatment measures. Sterol regulatory element-binding proteins （SREBP） are an important nuclear transcription factor， which mainly maintains the balance of lipid metabolism inside the body by activating the genes associated with the synthesis and uptake of cholesterol， fatty acids， and triglycerides， and therefore， SREBP are a target for the treatment of metabolic diseases. This article reviews the latest advances in SREBP in the pathogenesis of NAFLD and the latest evidence of SREBP-targeted therapy for NAFLD. It is worth noting that recent studies have shown that SREBP inhibition can cause liver injury together with autophagy damage. Therefore， excessive inhibition of lipogenesis may exert a counterproductive effect on the treatment of NAFLD. In conclusion， SREBP is a promising therapeutic target for NAFLD； the molecular mechanism of SREBP in lipid metabolism is regulated by many factors， and these factors are being deeply explored and analyzed， which has an important clinical significance for the treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Sterol Regulatory Element Binding Proteins,
- Lipogenesis,
- Inflammation,
- Fibrosis

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Mechanism of action of sterol regulatory element-binding proteins in nonalcoholic fatty liver disease and related therapeutic targets

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Mechanism of action of sterol regulatory element-binding proteins in nonalcoholic fatty liver disease and related therapeutic targets

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