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Volume 40 Issue 2
Feb.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(2): 239-245

Optimization of non-bioartificial liver technology and research advances in biological artificial liver

DOI: 10.12449/JCH240204

  • Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research，Forth Department of Liver Disease Center/Difficult and Complicated Liver Diseases and Artificial Liver Center，Beijing YouAn Hospital，Capital Medial University，Beijing 100069，China

Research funding:

National Key Research and Development Program of China (2022YFC2304400);

Beijing Hospitals Authority’s Ascent Plan (DFL20221501);

Construction Project of High-level Technology Talents in Public Health (2022-2-012);

Beijing Nova Program (20220484201)

More Information
  • Corresponding author: CHEN Yu， chybeyond1071@ccmu.edu.cn （ORICD： 0000-0003-1906-7486）
  • Received Date: 2023-11-13
  • Accepted Date: 2023-12-15
  • Published Date: 2024-02-19
    Abstract
  • Liver failure is a common clinical syndrome with rapid progression and poor prognosis. Currently， there are still limited internal medical treatment methods for liver failure， and artificial liver support therapy is an effective treatment method. Non-bioartificial liver technology is widely used in clinical practice， and clinicians should determine the starting time， mode， and specific parameters of treatment according to the pathophysiological mechanism and dynamic evolution process of the disease， as well as the specific conditions of patients. Compared with non-bioartificial liver， biological artificial liver can better simulate the biological function of liver cells. At present， substantial progress has been made in its core technology， and related clinical studies are being conducted actively， suggesting a vast potential for future development. This article summarizes and discusses the optimization of non-bioartificial liver technology and the advances in biological artificial liver， in order to provide a reference for the clinical application and research of artificial liver technology.

     

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