Mechanism of action of follicular helper T cells in autoimmune hepatitis

Longlong LUO; Lifei WANG; Guojing XING; Ying ZHENG; Lixia LU; Chuyi LI; Bin LI; Jun MA; Xiaohui YU; Jiucong ZHANG

doi:10.12449/JCH240727

Volume 40 Issue 7

Jul. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(7): 1466-1469

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Mechanism of action of follicular helper T cells in autoimmune hepatitis

DOI: 10.12449/JCH240727

Longlong LUO^{1a, 2},
Lifei WANG^{1a, 2},
Guojing XING^{1a, 3},
Ying ZHENG^1a,
Lixia LU^1a,
Chuyi LI^1a,
Bin LI^1a,
Jun MA^1b,
Xiaohui YU^{1a
,
,
,},
Jiucong ZHANG^{1a
,
,
,}

1a.
Department of Gastroenterology Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
1b.
Basic Medical Laboratory Gansu Provincial Key Laboratory of Stem Cells and Genetic Drugs The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
2.
The First Clinical Medical School of Gansu University of Chinese Medicine，Lanzhou 730000，China
3.
Department of Gastroenterology，General Hospital of Ningxia Medical University，Yinchuan 750001，China

Research funding:

Gansu Province Science and Technology Plan Project Assignment (21JR7RA017);

Gansu Province Science and Technology Plan Project Assignment (22YF7FA105);

Gansu Province Health Industry Scientific Research Plan Project Contract (GSWSKY2021-054)

More Information

Corresponding author: YU Xiaohui， yuxiaohui528@126.com （ORCID： 0000-0002-8633-3281）; ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）
Received Date: 2023-10-26
Accepted Date: 2023-11-21
Published Date: 2024-07-25

Abstract

Abstract

Autoimmune hepatitis （AIH） is a type of chronic hepatitis caused by the attack of hepatocytes by the autoimmune system， and with the prolongation of disease course， it may gradually progress to liver cirrhosis and even hepatocellular carcinoma. Although great achievements have been made in the understanding and treatment of AIH， its etiology and pathogenesis still remain unclear. T cells play a crucial role in the development and progression of AIH， and by focusing on follicular helper T cells， this article elaborates on the research advances in follicular helper T cells in AIH， in order to provide new ideas and strategies for the clinical treatment of AIH.
- Hepatitis， Autoimmune,
- T Follicular Helper Cells,
- T-Lymphocytes， Regulatory,
- B-Lymphocytes

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References(36)

References

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Mechanism of action of follicular helper T cells in autoimmune hepatitis

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Mechanism of action of follicular helper T cells in autoimmune hepatitis

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