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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 7
Jul.  2024
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Article Contents

Clinical cure of acute hepatitis B virus infection-related liver failure with HBsAg seroconversion: A case report

DOI: 10.12449/JCH240724
Research funding:

National Key Research and Development Program of China (2022YFC2305100);

National Natural Science Foundation of China (92169121);

Wuhan Institute of Virology, CAS (JXBS001)

More Information
  • Corresponding author: ZHENG Xin, xinz@hust.edu.cn (ORCID: 0000-0001-6564-7807)
  • Received Date: 2023-11-16
  • Accepted Date: 2023-12-25
  • Published Date: 2024-07-25
  • About 1% of the patients with acute hepatitis B can progress to acute liver failure, and 75% of the patients with hepatitis B virus (HBV)-related acute liver failure need to undergo liver transplantation or face death. This article reports a patient with HBV infection-related acute liver failure who achieved clinical cure and HBsAg seroconversion after antiviral therapy and symptomatic/supportive treatment, and dynamic monitoring was performed for immunological markers in peripheral blood.

     

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  • [1]
    Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure(2018)[J]. J Clin Hepatol, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.

    中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 临床肝胆病杂志, 2019, 35( 1): 38- 44. DOI: 10.3969/j.issn.1001-5256.2019.01.007.
    [2]
    LIANG TJ. Hepatitis B: The virus and disease[J]. Hepatology, 2009, 49( 5 Suppl): S13- S21. DOI: 10.1002/hep.22881.
    [3]
    JIA JD, WEI L, HOU JL, et al. Chinese standards for diagnosis and treatment of liver disease-White paper excerpt[J]. J Clin Hepatol, 2014, 30( 3): 197- 209. DOI: 10.3969/j.issn.1001-5256.2014.03.002.

    贾继东, 魏来, 侯金林, 等.《中国肝病诊疗管理规范》白皮书(节选)[J]. 临床肝胆病杂志, 2014, 30( 3): 197- 209. DOI: 10.3969/j.issn.1001-5256.2014.03.002.
    [4]
    GUIDOTTI LG, ISOGAWA M, CHISARI FV. Host-virus interactions in hepatitis B virus infection[J]. Curr Opin Immunol, 2015, 36: 61- 66. DOI: 10.1016/j.coi.2015.06.016.
    [5]
    KONDO Y, KOBAYASHI K, ASABE S, et al. Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8 T lymphocytes in fulminant hepatitis B[J]. Liver Int, 2004, 24( 6): 561- 567. DOI: 10.1111/j.1478-3231.2004.0982.x.
    [6]
    CHEN ZC, DIAZ G, POLLICINO T, et al. Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure[J]. Proc Natl Acad Sci U S A, 2018, 115( 48): E11369- E11378. DOI: 10.1073/pnas.1809028115.
    [7]
    SHINGINA A, MUKHTAR N, WAKIM-FLEMING J, et al. Acute liver failure guidelines[J]. Am J Gastroenterol, 2023, 118( 7): 1128- 1153. DOI: 10.14309/ajg.0000000000002340.
    [8]
    ZHANG Z, ZHANG JY, WHERRY EJ, et al. Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B[J]. Gastroenterology, 2008, 134( 7): 1938- 1949. DOI: 10.1053/j.gastro.2008.03.037.
    [9]
    KHAN AR, HAMS E, FLOUDAS A, et al. PD-L1hi B cells are critical regulators of humoral immunity[J]. Nat Commun, 2015, 6: 5997. DOI: 10.1038/ncomms6997.
    [10]
    XIONG SE, ZHU D, LIANG BY, et al. Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss[J]. EBioMedicine, 2021, 69: 103464. DOI: 10.1016/j.ebiom.2021.103464.
    [11]
    SPRENGERS D, van der MOLEN RG, KUSTERS JG, et al. Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans[J]. J Hepatol, 2006, 45( 2): 182- 189. DOI: 10.1016/j.jhep.2005.12.022.
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