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Vol.40 No.6 (284 in total) Jun. 2024
Theme Issue: Pathological Diagnosis of Hepatobiliary and Pancreatic Diseases
Executive Chief Editor: TENG Xiaodong  
The First Affiliated Hospital，Zhejiang University School of Medicine
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Editorial
Value of biopsy in evaluating the pathological progression of autoimmune hepatitis/pancreatitis
Xiaodong TENG
2024, 40(6): 1073-1075. DOI: 10.12449/JCH240601
Abstract(404) HTML (216) PDF (492KB)(69)
Abstract:
Liver biopsy is a crucial diagnostic tool for chronic liver diseases， allowing for direct observation of lesion morphology and aiding in precise evaluation. It is especially valuable in cases of autoimmune hepatitis， which exhibits complex morphological characteristics. This includes assessing gradi...
Expert Forum
Pathological diagnosis of alcoholic liver disease
Bin WANG
2024, 40(6): 1076-1081. DOI: 10.12449/JCH240602
Abstract(807) HTML (234) PDF (1853KB)(137) Cited By (1)
Abstract:
Alcoholic liver disease （ALD） is a liver disease caused by long-term heavy drinking. With the improvement in the living standard of Chinese people， the incidence rate of ALD tends to increase significantly. The typical pathological patterns of ALD include alcoholic steatosis， alcoholic steatohepatit...
Pathological diagnosis of autoimmune hepatitis
Wenjun YANG
2024, 40(6): 1082-1087. DOI: 10.12449/JCH240603
Abstract(602) HTML (360) PDF (1291KB)(114)
Abstract:

Autoimmune hepatitis （AIH） is an immune-mediated inflammatory disease of the liver parenchyma， which is characterized by hypergammaglobulinemia， the presence of autoantibodies， and typical abnormalities in liver histology； however， the diverse clinical manifestations of AIH and the lack of specific ...
Pathological diagnosis of primary biliary cholangitis
Qiupeng WANG, Meifu GAN
2024, 40(6): 1088-1092. DOI: 10.12449/JCH240604
Abstract(474) HTML (342) PDF (1016KB)(94)
Abstract:
In recent years， new advances have been achieved for the research on the pathogenesis， diagnosis， and treatment of primary biliary cholangitis （PBC）. Accurate diagnosis， prognosis assessment， and risk stratification based on the clinicopathological features of patients are important for the treatmen...
Pathological diagnosis of cholestatic liver disease
Jiping ZHANG
2024, 40(6): 1093-1099. DOI: 10.12449/JCH240605
Abstract(649) HTML (377) PDF (1969KB)(131) Cited By (2)
Abstract:
Cholestatic liver disease （CLD） is a group of liver diseases caused by various reasons， such as abnormal bile metabolism， blocked outflow， and bile duct injury， and the major causes of CLD include drugs， poisons， immunity， genetics， obstruction， infection， and tumor. Cholestasis is a common patholog...
Pathological diagnosis of autoimmune pancreatitis
Ke SUN
2024, 40(6): 1100-1106. DOI: 10.12449/JCH240606
Abstract(550) HTML (134) PDF (1309KB)(83)
Abstract:
Autoimmune pancreatitis （AIP） is a rare disease， and its diagnosis should be made based on a comprehensive evaluation of clinical， radiological， serological， and pathological findings. At present， AIP is classified into two subtypes of type 1 （identified as the pancreatic manifestation of IgG4-relat...
Guideline
Chinese expert consensus on the diagnosis and treatment of HIV co-infection with HBV and HCV
Committee on HIV/Liver Diseases， Chinese Association of STD and AIDS Prevention and Control； Guangzhou Eighth People’s Hospital， Guangzhou Medical University
2024, 40(6): 1107-1113. DOI: 10.12449/JCH240607
Abstract(592) HTML (276) PDF (769KB)(164) Cited By (1)
Abstract:
Guidelines for integrated traditional Chinese and Western medicine diagnosis and treatment of severe acute pancreatitis
Drafting Group of Guidelines for Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment of Severe Acute Pancreatitis， Chinese Association of Traditional Chinese Medicine
2024, 40(6): 1114-1125. DOI: 10.12449/JCH240608
Abstract(985) HTML (159) PDF (949KB)(298) Cited By (6)
Abstract:
Severe acute pancreatitis （SAP） is characterized by rapid onset and progression， complex clinicopathological changes， and a mortality rate of as high as 20%‍ ‍—‍ ‍30%. Long-term clinical practice and basic research have shown that relying solely on Western medicine for the treatment of SAP may not a...
Viral Hepatitis
Correlation of serum angiopoietin-1， angiopoietin-2， and angiopoietin-1/angiopoietin-2 ratio with HBV DNA and alanine aminotransferase in patients with chronic hepatitis B or liver cirrhosis
Minghua LIN, Yuan CHANG, Fang LIU, Yanxiang HUANG, Hangfei XU
2024, 40(6): 1126-1129. DOI: 10.12449/JCH240609
Abstract(337) HTML (142) PDF (661KB)(50) Cited By (1)
Abstract:
Objective To investigate the correlation of serum angiopoietin-1 （Ang-1）， angiopoietin-2 （Ang-2）， and Ang-1/Ang-2 ratio with HBA DNA and alanine aminotransferase （ALT） in patients with chronic hepatitis B （CHB） or liver cirrhosis. Methods Clinical data and serum specimens were collected from 99 pati...
Expression levels of serum high-mobility group box 1， soluble CD163， and prostaglandin E2 in patients with hepatitis B virus-related chronic-on-acute liver failure and their value in predicting prognosis
Chenlu HAN, Haijun LIANG, Daokun YANG, Haiyan CHANG, Shuai WEI, Xingwei WANG, Haili GAO
2024, 40(6): 1130-1135. DOI: 10.12449/JCH240610
Abstract(334) HTML (148) PDF (826KB)(38) Cited By (1)
Abstract:
Objective To investigate the expression levels of serum high-mobility group box 1 （HMGB1）， soluble CD163 （sCD163）， and prostaglandin E2 （PGE2） in patients with hepatitis B virus-related chronic-on-acute liver failure （HBV-ACLF）， and to evaluate the value of the three indicators used alone or in comb...
Fatty Liver Disease
Population distribution of non-alcoholic fatty liver disease before and after renaming and risk factors for liver fibrosis in metabolic dysfunction-associated steatotic liver disease
Yan LI, Xuebing YAN, Zhonghua LU, Fang JI
2024, 40(6): 1136-1141. DOI: 10.12449/JCH240611
Abstract(513) HTML (130) PDF (657KB)(87) Cited By (1)
Abstract:
Objective To investigate the population distribution of non-alcoholic fatty liver disease before and after renaming and the association between the types of metabolic risk factors （MRF） for metabolic dysfunction-associated steatotic liver disease （MASLD） and advanced liver fibrosis. Methods This stu...
Liver Fibrosis and Liver Cirrhosis
Effect of oxaliplatin on the activation of hepatic stellate cells and its mechanism
Cunkai WANG, Yijun WANG, Dandan WANG, Xiaoli XIE, Hongyu LIU, Yun BAI, Huiqing JIANG, Yuzhen WANG
2024, 40(6): 1142-1148. DOI: 10.12449/JCH240612
Abstract(301) HTML (152) PDF (1223KB)(31)
Abstract:
Objective To investigate the effect of oxaliplatin on the activation of hepatic stellate cells （HSCs）， as well as the association of oxaliplatin with microRNA-30a-5p and autophagy. Methods HSC-LX2 cells were cultured and divided into groups according to the following three protocols： control group， ...
Construction of a risk prediction model for overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with hepatitis B cirrhosis and portal hypertension
Lanjing WANG, Jianping QIN, Xin YAO, Qi QI, Lin LIU, Shanhong TANG
2024, 40(6): 1149-1155. DOI: 10.12449/JCH240613
Abstract(418) HTML (134) PDF (915KB)(47) Cited By (2)
Abstract:
Objective To investigate the influencing factors for overt hepatic encephalopathy （OHE） in patients with hepatitis B cirrhosis after transjugular intrahepatic portosystemic shunt （TIPS）， and to construct an individualized risk prediction model. Methods A total of 302 patients with hepatitis B cirrho...
Association between serum endothelial cell-specific molecule 1 and cirrhotic cardiomyopathy
Lixia MA, Xinhuan WEI, Zhenhuan CAO, Jing ZHANG
2024, 40(6): 1156-1161. DOI: 10.12449/JCH240614
Abstract(322) HTML (142) PDF (699KB)(27)
Abstract:
Objective Cirrhotic cardiomyopathy （CCM） refers to cardiac dysfunction and electrophysiological disorder caused by liver cirrhosis and is closely associated with the prognosis of patients with liver cirrhosis. Endothelial cell-specific molecule 1 （endocan） can be used as a diagnostic marker for card...
Liver Neoplasm
Predictive value of continuous monitoring of indocyanine green retention rate at 15 minutes combined with standard residual liver volume for hepatic insufficiency in patients with hepatocellular carcinoma after partial hepatectomy
Yujun LUO, Yamin ZHANG
2024, 40(6): 1162-1168. DOI: 10.12449/JCH240615
Abstract(466) HTML (130) PDF (797KB)(30)
Abstract:
Objective To investigate the value of continuous monitoring of indocyanine green retention rate at 15 minutes （ICG-R15） combined with standard residual liver volume （SRLV） in predicting hepatic insufficiency after partial hepatectomy. Methods Clinical data and SRLV data were collected from 70 patien...
Efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in treatment of hepatocellular carcinoma
Changwang ZHANG, Ninghan WU, Cong WANG, Zheng ZHENG, Siming GAO, Changpeng ZOU, Sujing ZHANG, Na LI
2024, 40(6): 1169-1174. DOI: 10.12449/JCH240616
Abstract(398) HTML (186) PDF (883KB)(31)
Abstract:
Objective To investigate the efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in the treatment of hepatocellular carcinoma （HCC）. Methods A total of 103 HCC patients who were admitted to our hospital from June 2020 to June 2023 were enrolled and randomly divided int...
Effect of iridoid glycosides from Boschniakia rossica on epithelial-mesenchymal transition of HepG2 cells induced by transforming growth factor-beta 1
Aihua JIN, Jiebo ZHU, Xuezhe YIN, Jishu QUAN
2024, 40(6): 1175-1182. DOI: 10.12449/JCH240617
Abstract(365) HTML (131) PDF (1510KB)(26) Cited By (1)
Abstract:
Objective To investigate the effect of iridoid glycosides from Boschniakia rossica （IGBR） on epithelial-mesenchymal transition （EMT） of HepG2 hepatoma cells induced by transforming growth factor-beta 1 （TGF-β1）. Methods HepG2 hepatoma cells were induced by 10 μg/L TGF-β1 to construct an EMT model of...
Impact of cancer-associated fibroblasts on immunotherapy and liver metastasis in colorectal cancer
Xiaoqing WANG, Jie LONG, Fei WANG, Zhexiong LIAN
2024, 40(6): 1183-1190. DOI: 10.12449/JCH240618
Abstract(704) HTML (312) PDF (4057KB)(57)
Abstract:
Objective To investigate the impact of cancer-associated fibroblasts （CAFs） on immunotherapy and liver metastasis in colorectal cancer （CRC）. Methods The single-cell sequencing data （GSE205506） of CRC patients with mismatch repair deficiency （MMRd） were downloaded from the gene expression omnibus da...
Other Liver Disease
Efficacy and safety of artificial liver support therapy with a selective plasma separator in low-platelet count patients with acute-on-chronic liver failure
Shoujuan LI, Li WANG, Ming ZHOU, Bei WU, Lei WANG, Meng DUAN, Hongfan LIAO, Ruiqing HU, Zhaoxia HU, Li ZHU, Juan HU
2024, 40(6): 1191-1195. DOI: 10.12449/JCH240619
Abstract(341) HTML (158) PDF (697KB)(34)
Abstract:
Objective To investigate the efficacy and safety of artificial liver support therapy with an Evanure-4A selective membrane plasma separator and its influence on platelet count in the treatment of patients with acute-on-chronic liver failure （ACLF） patients with different platelet counts. Methods A t...
Risk factors for pulmonary infection in patients with acute-on-chronic liver failure and establishment of a predictive model
Lijingzi WANG, Pei LI, Ye ZHANG, Jianqi LIAN, Lan ZHANG, Shasha WU, Congmin SHI, Xiao DANG
2024, 40(6): 1196-1202. DOI: 10.12449/JCH240620
Abstract(359) HTML (156) PDF (827KB)(38)
Abstract:
Objective To investigate the risk factors for pulmonary infection in patients with acute-on-chronic liver failure （ACLF）， and to establish a predictive model. Methods A retrospective analysis was performed for 585 ACLF patients who were admitted to Department of Infectious Diseases， The Second Affil...
Value of different assessment scales in the diagnosis of drug-induced liver injury
Jiaxi MA, Tiantian YAO, Hao CHENG, Dan LIU, Yuhan ZHANG, Siyuan DU, Linfei DONG, Linhui HU, Yan WANG, Guiqiang WANG
2024, 40(6): 1203-1208. DOI: 10.12449/JCH240621
Abstract(464) HTML (108) PDF (601KB)(55) Cited By (1)
Abstract:
Objective To determine the scores of patients with a confirmed diagnosis of drug-induced liver injury （DILI） using Roussel Uclaf Causality Assessment Method （RUCAM）， Maria & Victorino assessment scale， and Revised Electronic Causality Assessment Method （RECAM）， to compare the accuracy of the thr...
Effect of mesenchymal stem cells combined with immunosuppressants on immune rejection in a rat model of liver transplantation
Haitao LI, Saihua YU, Lihong CHEN, Zisen LAI, Haiyan LIU, Hongzhi LIU, Conglong. SHEN
2024, 40(6): 1209-1214. DOI: 10.12449/JCH240622
Abstract(328) HTML (124) PDF (7108KB)(32) Cited By (1)
Abstract:
Objective To investigate the effect of mesenchymal stem cells （MSCs） combined with immunosuppressants （IS） on immune rejection in a rat model of liver transplantation. Methods F344 rats were divided into Normal group （without any intervention）， PS group （injected with an equal volume of normal salin...
Biliary Disease
Association between hypertension and the risk of gallstone disease
Wenqian YU, Linjun XIE, Shiyi LI, Yanmei LOU, Guoheng JIANG, Hongyu LI, Zitong YAN, Xuan BAI, Jing LUO, Chi ZHANG, Guangcan LI, Xuefeng SHAN, Xin WANG
2024, 40(6): 1215-1225. DOI: 10.12449/JCH240623
Abstract(473) HTML (185) PDF (1424KB)(41) Cited By (1)
Abstract:
Objective This article aims to investigate the association between hypertension and the risk of GSD by conducting a national multicenter study， a systematic review， and a meta-analysis. Methods The study was conducted in three stages. In the first stage， subjects were recruited for health examinatio...
Pancreatic Disease
Value of skeletal muscle index combined with interleukin-6 and activin A in predicting early-stage pancreatic cancer cachexia
Xinsheng LI, Limin ZHANG, Shunxiang WANG, Ningning FENG
2024, 40(6): 1226-1230. DOI: 10.12449/JCH240624
Abstract(311) HTML (131) PDF (670KB)(36)
Abstract:
Objective To investigate the value of L3 skeletal muscle index （L3-SMI） combined with interleukin-6 （IL-6） and activin A in predicting early-stage pancreatic cancer cachexia. Methods A total of 74 patients with pancreatic cancer who were diagnosed in Hebei Medical University Forth Hospital from July...
Establishment and in vivo imaging observation of a nude mouse model of type 2 diabetes mellitus and pancreatic cancer
Yongning XU, Xuehuan HUANG, Zhipan TANG, Ruohan LI, Wen QIN
2024, 40(6): 1231-1239. DOI: 10.12449/JCH240625
Abstract(571) HTML (168) PDF (1970KB)(35)
Abstract:
Objective To establish a nude mouse model of type 2 diabetes mellitus （T2DM） and pancreatic cancer that allows dynamic observation of tumor formation process and facilitates invivo research. Methods At first， human pancreatic cancer PANC-1 cells were transfected with lentiviral vector GV260 to const...
Review
Advances in the multi-omics research on nonalcoholic fatty liver disease
Mingxiu DUAN, Xinli CHEN, Weiyu CHANG, Yuan YANG, Shiqi YANG, Hui WU
2024, 40(6): 1240-1247. DOI: 10.12449/JCH240626
Abstract(691) HTML (286) PDF (944KB)(139) Cited By (2)
Abstract:
The prevalence rate of nonalcoholic fatty liver disease （NAFLD） reaches up to 30% around the world， and the disease has a serious impact on human health and constitutes a public health burden. Due to difficulties in the diagnosis and monitoring of NAFLD， it is important to identify potential drug ta...
Exercise intervention prescription for postmenopausal women with nonalcoholic fatty liver disease and related comorbidities
Jie JU, Xing WANG, Xinge ZHANG, Changyu YANG, Peng LIU
2024, 40(6): 1248-1254. DOI: 10.12449/JCH240627
Abstract(349) HTML (150) PDF (722KB)(38)
Abstract:
The prevalence rate of nonalcoholic fatty liver disease （NAFLD） in postmenopausal women is significantly higher than that in premenopausal women and even exceeds that in men of the same age group， and exercise intervention remains an effective method for the prevention and treatment of NAFLD in post...
Research advances in drug-induced autoimmune-like hepatitis
Qinrong LI, Ying YAO, Zhiyuan XU
2024, 40(6): 1255-1258. DOI: 10.12449/JCH240628
Abstract(388) HTML (213) PDF (574KB)(79)
Abstract:
Drug-induced autoimmune-like hepatitis （DI-ALH） is a special clinical phenotype of drug-induced liver injury and has similar clinical features and laboratory test results to autoimmune hepatitis， and it is often difficult to distinguish them through liver biopsy. Therefore， correct differential diag...
Risk factors and predictive models for liver cancer after sustained virologic response in hepatitis C
Shanshan XU, Lixia QIU, Yali LIU, Jing ZHANG
2024, 40(6): 1259-1263. DOI: 10.12449/JCH240629
Abstract(338) HTML (130) PDF (627KB)(36) Cited By (1)
Abstract:
Hepatitis C is one of the main causes of liver cancer. With the application of direct-acting antiviral agents， more than 95% of patients can achieve the eradication of hepatitis C virus and obtain sustained virologic response （SVR）. Effective antiviral therapy can change the natural course of hepati...
Role of extracellular vesicles of different origins in the development and progression of hepatocellular carcinoma
Tingting SHI, Runbing ZHANG, Yang WU, Yani ZHANG, Lingling ZHU, Chun GAO, Jingjing JIANG, Xiaofeng ZHENG, Jiucong ZHANG
2024, 40(6): 1264-1268. DOI: 10.12449/JCH240630
Abstract(321) HTML (145) PDF (878KB)(35) Cited By (2)
Abstract:
Hepatocellular carcinoma （HCC） is the most common type of primary liver cancer and the third leading cause of cancer-related deaths， and it is a serious threat to human health and has become a clinical problem that needs to be solved urgently. Extracellular vesicles （EV） are membrane vesicles contai...
Regulatory effect of caveolin-1 in liver diseases
Junyi ZHU, Ruirui LI, Yixue SHU, Quan SUN
2024, 40(6): 1269-1274. DOI: 10.12449/JCH240631
Abstract(384) HTML (183) PDF (979KB)(36)
Abstract:
Caveolin-1 （CAV1） is a structural protein of caveolae on the plasma membrane and is an important regulatory factor for liver function. CAV1 regulates hepatic lipid deposition， lipid and glucose metabolism， mitochondrial function， and hepatocyte proliferation through various molecular pathways. There...
Role of T-cell immunoglobulin and mucin domain-containing molecule 3 in the development and progression of liver diseases
Shiyu YUAN, Huanhuan YANG, Yingmei TANG
2024, 40(6): 1275-1280. DOI: 10.12449/JCH240632
Abstract(420) HTML (213) PDF (668KB)(33)
Abstract:
T-cell immunoglobulin and mucin domain-containing molecule-3 （Tim-3） is a member of the Tim family and has been a research hotspot in recent years. As a negative regulatory factor， Tim-3 exerts different effects by binding to different ligands. Tim-3 is expressed in various types of immune cells， su...
Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure
Haimei GUAN, Kan ZHANG, Weiyu CHEN, Guobao LI, Yangling ZENG, Riyun ZHANG, Tianwen WANG, Baohua XIE, Dewen MAO
2024, 40(6): 1281-1288. DOI: 10.12449/JCH240633
Abstract(446) HTML (341) PDF (835KB)(37)
Abstract:
Acute liver failure （ALF） is one of the most critical liver diseases in clinical practice and seriously affects the life and health of Chinese people. Due to its high morbidity and mortality rates， unclear pathogenesis， and limited treatment methods， ALF has become a major problem that needs to be s...
Introduction of High - quality Articles in Foreign Journals
Hepatology International｜Incidence, risk factors, and outcomes of acute liver injury in hospitalized adults with acute kidney injury: a large multicenter study
2024, 40(6): 1182-1182. DOI: 10.12449/JCH2406.gwqkjpwzjj1
Abstract(210) HTML (104) PDF (845KB)(18)
Abstract:
Journal of the American Heart Association｜Association of cardiopulmonary hemodynamics and mortality in veterans with liver cirrhosis: A retrospective cohort study
2024, 40(6): 1254-1254. DOI: 10.12449/JCH2406.gwqkjpwzjj2
Abstract(183) HTML (121) PDF (837KB)(19)
Abstract:
Acknowledgements
Current reviewers
2024, 40(6): 1202-1202. DOI: 10.12449/JCH2406.zhixie
Abstract(142) HTML (93) PDF (812KB)(13)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

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