中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Menu

Vol.40 No.5 (283 in total) May. 2024
Theme Issue: Futher Understanding of Antiviral Therapy for Special Populations with HBV Infection
Executive Chief Editor: DOU Xiaoguang  
Shengjing Hospital of China Medical University
Cover Content

 Previous Issue | Next Issue 

Display Method:
Editorial
Progress towards elimination of hepatitis B
Hui ZHUANG
2024, 40(5): 857-860. DOI: 10.12449/JCH240501
Abstract(1070) HTML (241) PDF (886KB)(269) Cited By (7)
Abstract:
This paper summarizes the latest progress in the elimination of hepatitis B worldwide and in China. Although the global burden of hepatitis B is decreasing， there is a large difference in the progress towards elimination across different countries， and among the 20 countries with the heaviest diseas...
Focus on the timing and strategies of antiviral therapy for special populations with chronic hepatitis B
Yang DING, Xiaoguang DOU
2024, 40(5): 861-865. DOI: 10.12449/JCH240502
Abstract(691) HTML (231) PDF (684KB)(193) Cited By (1)
Abstract:
Several factors need to be considered for special populations with chronic hepatitis B （CHB）， such as the family history of liver cirrhosis and liver cancer， age， disease stage， and antiviral response. It is necessary to select the appropriate timing of antiviral therapy and timely adjust antiviral ...
Expert Forum
Timing of antiviral therapy for pregnant women with HBV infection and normal alanine aminotransferase level aged >30 years
Qiuju SHENG, Yuhan WANG, Yang DING
2024, 40(5): 866-869. DOI: 10.12449/JCH240503
Abstract(499) HTML (188) PDF (592KB)(119)
Abstract:
Guidelines for the prevention and treatment of chronic hepatitis B （2022 edition） expanded the indications for antiviral therapy in patients with chronic hepatitis B. The guidelines recommend to initiate antiviral therapy for patients with chronic HBV infection who have a normal alanine aminotransfe...
Hepatitis B virus infection in children： Antiviral therapy for children with a normal alanine aminotransferase level
Lei FU
2024, 40(5): 870-874. DOI: 10.12449/JCH240504
Abstract(488) HTML (164) PDF (651KB)(84)
Abstract:
Chronic hepatitis B （CHB） is a major public health issue around the world， and there are currently about 2 million children with hepatitis B virus （HBV） infection in China. HBV infection in children tends to become chronic， leading to high risks of liver cirrhosis and liver cancer in adulthood. Trad...
Clinical controversies over antiviral therapy for patients in the immune-tolerant phase of hepatitis B virus infection
Linhui HU, Yan WANG
2024, 40(5): 875-879. DOI: 10.12449/JCH240505
Abstract(642) HTML (185) PDF (671KB)(124)
Abstract:
To achieve the goal of “eliminating viral hepatitis as a public health hazard by 2030”， extensive screening， active prevention， and antiviral therapy are currently recommended for chronic hepatitis B virus （HBV） infection； however， no consensus has been reached on whether to initiate antiviral thera...
Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos（t）ide analogues and its treatment strategies
Rongjiong ZHENG, Xiaobo LU
2024, 40(5): 880-883. DOI: 10.12449/JCH240506
Abstract(741) HTML (196) PDF (556KB)(139)
Abstract:
Highly effective oral antiviral therapy with low drug resistance can strongly inhibit HBV replication； however， some patients may still have low-level viremia （LLV） after receiving entecavir， tenofovir disoproxil fumarate， tenofovir alafenamide， or tenofovir amibufenamide for 48 weeks or more. Multi...
Guideline
Expert consensus on integrated traditional Chinese and Western medicine diagnosis and treatment of chronic hepatitis B
Expert Committee on Hepatology， Doctor Society of Integrative Medicine， Chinese Medical Doctor Association
2024, 40(5): 884-892. DOI: 10.12449/JCH240507
Abstract(1204) HTML (328) PDF (968KB)(366) Cited By (8)
Abstract:
Chronic hepatitis B （CHB） is still a major public health issue in China， and without effective control， it can further progress to liver cirrhosis and liver cancer， bringing huge social and economic burdens. At present， antiviral therapy is the main treatment method for CHB， and integrated tradition...
Standard for diagnosis and treatment of primary liver cancer （2024 edition）
National Health Commission of the People’s Republic of China
2024, 40(5): 893-918. DOI: 10.12449/JCH240508
Abstract(6706) HTML (696) PDF (1769KB)(2349)
Abstract:
Guideline for traditional Chinese medicine diagnosis and treatment of primary liver cancer
Branch of Hepatobiliary Diseases， China Association of Chinese Medicine
2024, 40(5): 919-927. DOI: 10.12449/JCH240509
Abstract(1317) HTML (440) PDF (832KB)(354) Cited By (8)
Abstract:
Primary liver cancer is one of the most common malignant tumors in China and has been a major threat to human health. With advances in the basic and clinical research on primary liver cancer in recent years， the diagnosis and treatment methods for primary liver cancer have been constantly enriched. ...
Key recommendations in guidelines for the prevention， diagnosis， care and treatment for people with chronic hepatitis B infection released by the World Health Organization in 2024
Xiaowei AI, Mengyang ZHANG, Yameng SUN, Hong YOU
2024, 40(5): 928-933. DOI: 10.12449/JCH240510
Abstract(4079) HTML (578) PDF (2084KB)(1651)
Abstract:
In March 2024， the World Health Organization released the latest version of guidelines for the prevention， diagnosis， care and treatment for people with chronic hepatitis B infection. The guidelines were updated in several aspects， including expanding and simplifying the indications for chronic hepa...
Viral Hepatitis
Value of magnetic resonance imaging-proton density fat fraction in evaluating the degree and distribution characteristics of hepatic steatosis in patients with chronic hepatitis B virus infection
Limin WANG, Chao BAO, Kaiyue ZHAO, Jiehua JIN, Zhuozhao ZHENG, Yuan HUANG
2024, 40(5): 934-939. DOI: 10.12449/JCH240511
Abstract(742) HTML (203) PDF (616KB)(53)
Abstract:
Objective To investigate the value of magnetic resonance imaging-proton density fat fraction （MRI-PDFF） in evaluating hepatic steatosis in patients with chronic hepatitis B virus （HBV） infection. Methods The patients， aged >16 years， who visited the outpatient service or were hospitalized in Beij...
Serological features and liver histopathology of chronic hepatitis B patients with normal alanine aminotransferase
Shanshan LIU, Zhonghua LU
2024, 40(5): 940-945. DOI: 10.12449/JCH240512
Abstract(644) HTML (157) PDF (678KB)(87) Cited By (3)
Abstract:
Objective To investigate the liver histopathological features of chronic hepatitis B （CHB） patients with normal alanine aminotransferase （ALT） and their correlation with serological markers. Methods Clinical data were collected from 137 patients with normal ALT who were treated in Wuxi Fifth People’...
Fatty Liver Disease
Therapeutic effect of low-carbohydrate diet and lifestyle intervention on patients with lean nonalcoholic fatty liver disease
Shihua HE, Lu DAI, Jie ZHENG, Chuanghong WU, Guoxin HU
2024, 40(5): 946-951. DOI: 10.12449/JCH240513
Abstract(593) HTML (158) PDF (837KB)(70) Cited By (1)
Abstract:
Objective To investigate the therapeutic effect of low-carbohydrate diet and online lifestyle intervention on patients with lean nonalcoholic fatty liver disease （NAFLD）. Methods This study was conducted among 53 patients with lean NAFLD who attended Department of Infectious Diseases in Peking Unive...
Effect of NOD‑like receptor family pyrin domain containing 3 knockdown on a mouse model of nonalcoholic steatohepatitis induced by high-fat high-carbohydrate diet
Qian HUANG, Zhuoyuan WANG, Ziming AN, Xin XIN, Qinmei SUN, Xiaojun GOU, Yiyang HU, Qin FENG
2024, 40(5): 952-960. DOI: 10.12449/JCH240514
Abstract(515) HTML (142) PDF (1943KB)(45)
Abstract:
Objective To investigate the effect of NOD-like receptor family pyrin domain containing 3 （NLRP3） knockdown on a mouse model of nonalcoholic steatohepatitis （NASH） induced by high-fat high-carbohydrate （HFHC） diet. Methods A total of 44 mice were randomly divided into normal diet group （CON group） w...
Liver Fibrosis and Liver Cirrhosis
TCM constitution distribution and clinical features of patients with hepatitis B cirrhosis and dysplastic nodules
Mengbing FANG, Cheng LIU, Yu ZHANG, Jiayi ZENG, Zhiheng CHEN, Sheng LI, Xiaoling CHI, Huanming XIAO
2024, 40(5): 961-967. DOI: 10.12449/JCH240515
Abstract(482) HTML (170) PDF (775KB)(41)
Abstract:
Objective To investigate the characteristics of TCM constitution distribution in hepatitis B cirrhosis patients with dysplastic nodules （DN）， and to provide a basis for the prevention and treatment of precancerous lesions of liver cancer. Methods This study was conducted among 113 hepatitis B cirrho...
Effect of the protein kinase RNA-like endoplasmic reticulum kinase pathway in endoplasmic reticulum stress on hepatic stellate cell activation and collagen type I expression
Fengyan LI, Zefeng LIU, Yuyan XIA, Wenjuan WANG, Qi LI, Lixia TANG, Guo ZHANG
2024, 40(5): 968-974. DOI: 10.12449/JCH240516
Abstract(735) HTML (302) PDF (2128KB)(35) Cited By (2)
Abstract:
Objective To investigate the effect of the protein kinase RNA-like endoplasmic reticulum kinase （PERK）/eukaryotic initiation factor 2α （eIF2α） pathway in endoplasmic reticulum stress on the activation of hepatic stellate cells （HSC）. Methods Pathological sections of normal liver tissue after surgery...
Liver Neoplasm
Efficacy and safety of anti-PD-1 monoclonal antibody combined with sorafenib or lenvatinib in treatment of patients with Child-Pugh class B unresectable hepatocellular carcinoma
Wei SUN, Xiaoyan DING, Jinglong CHEN
2024, 40(5): 975-981. DOI: 10.12449/JCH240517
Abstract(519) HTML (169) PDF (874KB)(57) Cited By (2)
Abstract:
Objective To investigate the safety and efficacy of tyrosine kinase inhibitors combined with immune checkpoint inhibitors in the treatment of patients with Child-Pugh class B unresectable hepatocellular carcinoma （uHCC）. Methods A total of 96 patients with Child-Pugh class B uHCC who were admitted t...
Silencing essential meiotic endonuclease 1 inhibits the proliferation of liver cancer cells： A study of related mechanisms
Chun CHEN, Kexin WANG, Mengwen HE, Le LI, Chunyan WANG, Yan LIU, Dong JI
2024, 40(5): 982-988. DOI: 10.12449/JCH240518
Abstract(456) HTML (154) PDF (1933KB)(28)
Abstract:
Objective To investigate the expression of essential meiotic endonuclease 1 （EME1） in liver cancer tissue and its effect on the biological behavior of hepatoma cells. Methods The TCGA database was used to identify the differentially expressed genes between liver cancer tissue and paracancerous tissu...
Effect of ankyrin-repeat domain-containing protein 22 on human hepatoma cells and its mechanism
Junzhe CAI, Songbai LIU, Xiaobin FEI, Peng LIU, Changhao ZHU, Xing WANG, Yaozhen PAN
2024, 40(5): 989-996. DOI: 10.12449/JCH240519
Abstract(506) HTML (202) PDF (2397KB)(33)
Abstract:
Objective To investigate the effect of ankyrin-repeat domain-containing protein 22 （ANKRD22） on the proliferation， invasion， and migration of human hepatoma cells and its molecular mechanism. Methods The TCGA database was used to analyze the expression level of ANKRD22 in normal liver tissue and hep...
Other Liver Disease
Liver biopsy and clinical features of liver injury of unknown origin： An analysis of 94 cases
Shuqi LI, Meiya CHEN, Yang SONG, Fei ZHOU, Ermei CHEN, Ligang CHEN, Jingping ZHOU
2024, 40(5): 997-1002. DOI: 10.12449/JCH240520
Abstract(698) HTML (154) PDF (909KB)(69) Cited By (1)
Abstract:
Objective To summarize the liver biopsy and clinical features of patients with liver injury of unknown origin， and to investigate the value of ultrasound-guided percutaneous liver biopsy in the diagnosis of liver injury of unknown origin. Methods A retrospective analysis was performed for the clinic...
Mechanism of bis（2-ethylhexyl） phthalate in inducing cholestasis and liver injury in mice
Jiayi ZHANG, Yun YU, Fan ZHAO, Lu YE, Jianqing WANG
2024, 40(5): 1003-1008. DOI: 10.12449/JCH240521
Abstract(663) HTML (165) PDF (1455KB)(30) Cited By (1)
Abstract:
Objective To investigate the mechanism of bis（2-ethylhexyl） phthalate （DEHP） in inducing cholestasis and liver injury in mice. Methods In the in vivo experiment， adult female ICR mice were randomly divided into control group （corn oil） and DEHP group （200 mg/kg/d）， and a model of cholestasis was est...
Pancreatic Disease
Clinical features of acute pancreatitis in pregnancy and related risk factors
Di WU, Dahua DAI, Wenmei LIANG, Bao FU, Xiaoyun FU
2024, 40(5): 1009-1015. DOI: 10.12449/JCH240522
Abstract(406) HTML (172) PDF (736KB)(31) Cited By (1)
Abstract:
Objective To investigate the clinical features and maternal and fetal outcomes of acute pancreatitis in pregnancy （APIP） and the risk factors for disease aggravation， and to establish a predictive model. Methods A retrospective analysis was performed for 52 APIP patients who were admitted to Affilia...
Effect of high-frequency irreversible electroporation in the ablation of porcine pancreatic tissue
Rong XING, Jiru DU, Yuanchi WENG, Feng WANG, Chao LIU
2024, 40(5): 1016-1020. DOI: 10.12449/JCH240523
Abstract(459) HTML (406) PDF (1263KB)(42)
Abstract:
Objective To investigate the effect of high-frequency irreversible electroporation （H-FIRE） in the ablation of pig pancreatic tissue. Methods Laparotomy was conducted in this study， and needle electrodes were used to release electric pulses in 12 pigs. Three sets of parameters were established for a...
Review
Hepatitis B vaccine： From prevention to treatment
Yisi LIU, Shan REN, Sujun ZHENG, Xinyue CHEN
2024, 40(5): 1021-1025. DOI: 10.12449/JCH240524
Abstract(868) HTML (543) PDF (659KB)(142) Cited By (1)
Abstract:
Hepatitis B vaccination is the most economical and effective way to prevent HBV infection. The advances in molecular biology and genetic engineering have continuously improved the manufacturing process of vaccines， and hepatitis B vaccine has gradually developed from the initial plasma-derived vacci...
Role of HBeAg-induced immune activition and immunosuppression in chronic hepatitis B
Xinyang LI, Zhengkun TU
2024, 40(5): 1026-1031. DOI: 10.12449/JCH240525
Abstract(602) HTML (156) PDF (875KB)(110) Cited By (1)
Abstract:
Chronic hepatitis B induced by HBV infection is a significant risk factor leading to liver cirrhosis and liver cancer. Half a century ago， HBeAg was first discovered in the serum of HBV infected individuals， and although HBeAg does not participate in HBV infection or replication in hepatocytes， stud...
Advances in drug therapy for primary sclerosing cholangitis
Xia SHENG, Qingming JI, Xinyu LI, Lihong WANG, Junqi NIU
2024, 40(5): 1032-1038. DOI: 10.12449/JCH240526
Abstract(549) HTML (413) PDF (731KB)(82)
Abstract:
Primary sclerosing cholangitis （PSC） is a cholestatic disease characterized by chronic progressive bile duct inflammation and has a low incidence rate and poor prognosis in China. There is still no drug therapy that can change the course of PSC， and liver transplantation is the only effective treatm...
Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions
Ruijuan YAN, Junzhe JIAO, Yu HUANG, Shuguang YAN, Hailiang WEI, Zhanjie CHANG, Yingjun GUO, Jingtao LI
2024, 40(5): 1039-1043. DOI: 10.12449/JCH240527
Abstract(560) HTML (177) PDF (1010KB)(41) Cited By (1)
Abstract:
Liver macrophages are important immune cells in the liver， and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type， respectively， thereby playing a role in regulating inflammatory damage response. The malignant transformation of hepatic pr...
Role and mechanism of CC chemokines and their receptors in chronic liver diseases
Zixin ZHANG, Hui LI, Jiahui WANG, Yujing TAO, Xiaoyan ZENG
2024, 40(5): 1044-1049. DOI: 10.12449/JCH240528
Abstract(639) HTML (260) PDF (754KB)(43)
Abstract:
In recent years， the incidence rate of chronic liver diseases continues to rise， such as chronic hepatitis B， nonalcoholic fatty liver disease， liver fibrosis， liver cirrhosis， and hepatocellular carcinoma， and the age of onset gradually becomes younger. At present， the role of many CC chemokines in...
The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases
Yupei LIN, Xiaoping LIU, Yinbing LUO, Feiyan LI, Yingying LIAO, Shicong MO, Dewen MAO, Yanmei LAN
2024, 40(5): 1050-1056. DOI: 10.12449/JCH240529
Abstract(1194) HTML (228) PDF (936KB)(75)
Abstract:
The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration. In healthy livers， the Wnt signaling pathway is mostly inactive， but it is continuously overactivated during cell renewal or regeneration processes， as well as in certain pathological condition...
Role of β-glucuronidase in the formation of primary intrahepatic stones
Guo LI, Haijun YE, Zhikai XU, Wentao LI, Chenglei XU, Jiang LI
2024, 40(5): 1057-1061. DOI: 10.12449/JCH240530
Abstract(593) HTML (185) PDF (725KB)(35)
Abstract:
Primary intrahepatic stones （PIS） is a refractory disease with a high incidence rate in Southwest China， which greatly affects the life of patients. Metabolites， such as β-glucuronidase produced by chronic biliary tract infection， play an important role in the formation of pigmented stones. In addit...
Development of percutaneous transhepatic cholangioscopy and comparison of different techniques in treatment of cholelithiasis
Shengyu WANG, Shuodong WU
2024, 40(5): 1062-1067. DOI: 10.12449/JCH240531
Abstract(688) HTML (392) PDF (701KB)(73) Cited By (1)
Abstract:
Intrahepatic bile duct stone is a type of biliary system disease characterized by complex conditions and frequent recurrence， and traditional surgical treatment methods tend to cause various complications and have high requirements for surgical standards. Percutaneous transhepatic cholangioscopy （PT...
Pathogenesis, diagnosis, and treatment of pancreatogenic diabetes
Xiwang WANG, Jingjing JIN, Ying WANG, Chenxiao WANG, Yonghua ZHANG, Yajiao GU, Xiao WANG
2024, 40(5): 1068-1072. DOI: 10.12449/JCH240532
Abstract(1042) HTML (366) PDF (749KB)(89) Cited By (2)
Abstract:
Pancreatogenic diabetes is a type of diabetes mellitus secondary to exocrine pancreatic disease， and it was officially proposed by the American Diabetes Association in 2014， with chronic pancreatitis as the most common etiology， followed by pancreatic cancer. At present， the misdiagnosis rate of thi...
Introduction of High - quality Articles in Foreign Journals
Journal of Hepatology｜Endoscopic procedures in hepatology: Current trends and new developments
2024, 40(5): 960-960. DOI: 10.12449/JCH2405.gwqkjpwzjj1
Abstract(384) HTML (277) PDF (872KB)(26)
Abstract:
Journal of Hepatology｜An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis
2024, 40(5): 981-981. DOI: 10.12449/JCH2405.gwqkjpwzjj2
Abstract(327) HTML (187) PDF (891KB)(25)
Abstract:
Hepatology Communications｜Proton pump inhibitor treatment is associated with acute-on-chronic liver failure in patients with advanced cirrhosis
2024, 40(5): 1002-1002. DOI: 10.12449/JCH2405.gwqkjpwzjj3
Abstract(282) HTML (116) PDF (892KB)(30)
Abstract:
Journal of Gastroenterology and Hepatology｜Novel protein C6ORF120 promotes liver fibrosis by activating hepatic stellate cells through the PI3K/Akt/mTOR pathway
2024, 40(5): 1049-1049. DOI: 10.12449/JCH2405.gwqkjpwzjj4
Abstract(246) HTML (109) PDF (907KB)(20)
Abstract:
Acknowledgements
Current reviewers
2024, 40(5): 865-865. DOI: 10.12449/JCH2405.zhixie
Abstract(230) HTML (105) PDF (875KB)(14)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

Address: 461 Xinjiang Road, Changchun

Submit：0431-88782044

Peer review：0431-88783542

Email：lcgdb@vip.163.com

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

YesterdayIP[2433]YesterdayPV[3993]TodayIP[1235]TodayPV[1838]Online[109]

Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd