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Volume 40 Issue 5
May  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(5): 1016-1020

Effect of high-frequency irreversible electroporation in the ablation of porcine pancreatic tissue

DOI: 10.12449/JCH240523
  • 1.

    School of Medical Devices，Shanghai University of Medicine & Health Sciences，Shanghai 201318，China

  • 2.

    Department of Dermatology，Tongren Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200336，China

  • 3.

    Department of Pancreatic Surgery，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

  • 4.

    Liver Disease Center，The Affiliated Hospital of Qingdao University，Qingdao，Shandong 266003，China

Research funding:

Shandong Provincial Natural Science Foundation Project (ZR2023MH111)

More Information
  • Corresponding author: LIU Chao， liuchao2311@126.com （ORCID： 0009-0002-9203-5800）
  • Received Date: 2023-08-30
  • Accepted Date: 2023-10-27
  • Published Date: 2024-05-25
    Abstract
  •   Objective  To investigate the effect of high-frequency irreversible electroporation （H-FIRE） in the ablation of pig pancreatic tissue.  Methods  Laparotomy was conducted in this study， and needle electrodes were used to release electric pulses in 12 pigs. Three sets of parameters were established for ablation at the low， medium， and high values of field strength （1 000 V/cm， 1 500 V/cm， and 2 500 V/cm）. The groups were compared in terms of the data including postoperative recovery， ablation area， and histopathological features to validate the safety and efficacy of H-FIRE in the ablation of porcine pancreatic tissue. The paired t-test was used for comparison of continuous data between two groups.  Results  All pigs in the experiment survived and showed a good effect of ablation. The histopathological analysis of all groups showed thorough and effective ablation， with a clear boundary between the ablated area and the normal tissue area. The mean ablation area in the low， medium， and high field strength groups was 30.96±3.73 mm2， 51.93±25.26 mm2， and 108.90±55.23 mm2， respectively， and the high and medium field strength groups had a significantly larger ablation area than the low field strength group （both P<0.05）， while there was no significant difference in ablation area between the medium and high field strength groups （P>0.05）.  Conclusion  H-FIRE ablation is safe and effective for porcine pancreatic tissue under specific ablation parameters.

     

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