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Volume 40 Issue 5
May  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(5): 1026-1031

Role of HBeAg-induced immune activition and immunosuppression in chronic hepatitis B

DOI: 10.12449/JCH240525

  • Laboratory of Tumor Immunology，The First Hospital of Jilin University，Changchun 130021，China

Research funding:

Jilin Province Science and Technology Development Plan Project Natural Science Foundation Project (20190201245JC)

More Information
  • Corresponding author: TU Zhengkun， tuzhengkun@hotmail.com （ORCID： 0000-0001-6803-2015）
  • Received Date: 2024-01-25
  • Accepted Date: 2024-02-22
  • Published Date: 2024-05-25
    Abstract
  • Chronic hepatitis B induced by HBV infection is a significant risk factor leading to liver cirrhosis and liver cancer. Half a century ago， HBeAg was first discovered in the serum of HBV infected individuals， and although HBeAg does not participate in HBV infection or replication in hepatocytes， studies have shown that it can interfere with the innate and adaptive immune responses of the host and play an important role in immune activation and immunosuppression during chronic HBV infection. HBV has no cytotoxicity to the infected hepatocytes， and the antiviral action and inflammatory response mediated by immune response determine whether HBV is cleared or induces liver inflammation-related diseases. Therefore， this article reviews the formation of HBeAg and its immune activation and immunosuppression mechanisms in chronic HBV infection， with a focus on the different immune effects caused by HBeAg on innate immune and adaptive immune cells， and this article also elaborates on the dual role of HBeAg in inducing immune responses and explores the conversion role of HBeAg in different stages of chronic HBV infection.

     

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