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Volume 40 Issue 5
May  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(5): 1050-1056

The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases

DOI: 10.12449/JCH240529
  • 1.

    Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China

  • 2a..

    Key Laboratory of Traditional Chinese Medicine Clinical Research

  • 2b..

    Guangxi Key Laboratory of Molecular Biology in Traditional Chinese Medicine Prevention and Treatment，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

Natioanal Natural Science Foundation Project (81960841);

Natioanal Natural Science Foundation Project (82274434);

Guangxi Natural Science Foundation Project (2020GXNSFBA297115);

Guangxi Natural Science Foundation Project (2023GXNSFAA026176);

Guangxi Natual Science Foundation Innovation Research Team Project (2020GXNSFAA297070);

Guangxi University Young and Middle School Teachers’ Basic Research Ability Enhancement Project (2022KY0299);

Innovation Project of General Post graduates in Guangxi University of Traditional Chinese Medicine (YCSY2022024)

More Information
  • Corresponding author: LAN Yanmei， lanyanmeixueshu@163.com （ORCID： 0000-0001-9304-0594）
  • Received Date: 2023-08-28
  • Accepted Date: 2023-10-12
  • Published Date: 2024-05-25
    Abstract
  • The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration. In healthy livers， the Wnt signaling pathway is mostly inactive， but it is continuously overactivated during cell renewal or regeneration processes， as well as in certain pathological conditions， diseases， precancerous states， and cancers. Persistent liver cell injury often leads to chronic liver diseases such as liver fibrosis， liver cirrhosis， and liver cancer. This article summarizes the basic structural features of the Wnt signaling pathway and analyzes its important role in the pathological progression of various liver diseases， so as to provide new ideas for the prevention and treatment of liver diseases in clinical practice.

     

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