中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 5
May  2024
Turn off MathJax
Article Contents

Role and mechanism of CC chemokines and their receptors in chronic liver diseases

DOI: 10.12449/JCH240528
Research funding:

General Program of the National Natural Science Foundation of China (82274323)

More Information
  • Corresponding author: LI Hui, 1400124746@qq.com (ORCID: 0000-0002-5919-1396)
  • Received Date: 2023-10-19
  • Accepted Date: 2023-12-12
  • Published Date: 2024-05-25
  • In recent years, the incidence rate of chronic liver diseases continues to rise, such as chronic hepatitis B, nonalcoholic fatty liver disease, liver fibrosis, liver cirrhosis, and hepatocellular carcinoma, and the age of onset gradually becomes younger. At present, the role of many CC chemokines in chronic liver diseases has been confirmed. This article summarizes the research advances in CC chemokines and their receptors that affect chronic liver diseases in recent years and explore their potential application in chronic liver diseases, so as to provide new ideas for the prevention and treatment of chronic liver diseases.

     

  • loading
  • [1]
    GRIFFITH JW, SOKOL CL, LUSTER AD. Chemokines and chemokine receptors: Positioning cells for host defense and immunity[J]. Annu Rev Immunol, 2014, 32: 659- 702. DOI: 10.1146/annurev-immunol-032713-120145.
    [2]
    EDDERKAOUI B. Potential role of chemokines in fracture repair[J]. Front Endocrinol(Lausanne), 2017, 8: 39. DOI: 10.3389/fendo.2017.00039.
    [3]
    FAHEY S, DEMPSEY E, LONG A. The role of chemokines in acute and chronic hepatitis C infection[J]. Cell Mol Immunol, 2014, 11( 1): 25- 40. DOI: 10.1038/cmi.2013.37.
    [4]
    WASMUTH HE, TACKE F, TRAUTWEIN C. Chemokines in liver inflammation and fibrosis[J]. Semin Liver Dis, 2010, 30( 3): 215- 225. DOI: 10.1055/s-0030-1255351.
    [5]
    GUSTAVSSON M. New insights into the structure and function of chemokine receptor: Chemokine complexes from an experimental perspective[J]. J Leukoc Biol, 2020, 107( 6): 1115- 1122. DOI: 10.1002/JLB.2MR1219-288R.
    [6]
    CHARO IF, RANSOHOFF RM. The many roles of chemokines and chemokine receptors in inflammation[J]. N Engl J Med, 2006, 354( 6): 610- 621. DOI: 10.1056/NEJMra052723.
    [7]
    BAGGIOLINI M, LOETSCHER P. Chemokines in inflammation and immunity[J]. Immunol Today, 2000, 21( 9): 418- 420. DOI: 10.1016/s0167-5699(00)01672-8.
    [8]
    SALLUSTO F, MACKAY CR, LANZAVECCHIA A. The role of chemokine receptors in primary, effector, and memory immune responses[J]. Annu Rev Immunol, 2000, 18: 593- 620. DOI: 10.1146/annurev.immunol.18.1.593.
    [9]
    WHITE GE, IQBAL AJ, GREAVES DR. CC chemokine receptors and chronic inflammation: Therapeutic opportunities and pharmacological challenges[J]. Pharmacol Rev, 2013, 65( 1): 47- 89. DOI: 10.1124/pr.111.005074.
    [10]
    SEEGER C, MASON WS. Molecular biology of hepatitis B virus infection[J]. Virology, 2015, 479-480: 672- 686. DOI: 10.1016/j.virol.2015.02.031.
    [11]
    HU LS, ZHU Y, ZHANG JQ, et al. Potential circulating biomarkers of circulating chemokines CCL5, MIP-1β and HA as for early detection of cirrhosis related to chronic HBV(hepatitis B virus) infection[J]. BMC Infect Dis, 2019, 19( 1): 523. DOI: 10.1186/s12879-019-4130-0.
    [12]
    LI Y, WANG CM, ZHAO T, et al. Hepatitis B virus X protein modulates chemokine CCL15 upregulation in hepatocellular carcinoma[J]. Anticancer Agents Med Chem, 2021, 21( 16): 2198- 2203. DOI: 10.2174/1871520621666210302083407.
    [13]
    ZHANG K, LIU YQ, YANG XA, et al. HBV promotes the recruitment of IL-17 secreting T cells via chemokines CCL22 and CCL17[J]. Liver Int, 2020, 40( 6): 1327- 1338. DOI: 10.1111/liv.14438.
    [14]
    ZHUO JY, LU D, LIN ZY, et al. CC motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells[J]. Hepatobiliary Pancreat Dis Int, 2020, 19( 5): 440- 448. DOI: 10.1016/j.hbpd.2019.12.006.
    [15]
    YAN Y, ZHAO W, LIU W, et al. CCL19 enhances CD8+ T-cell responses and accelerates HBV clearance[J]. J Gastroenterol, 2021, 56( 8): 769- 785. DOI: 10.1007/s00535-021-01799-8.
    [16]
    KHANAM A, GHOSH A, CHUA JV, et al. Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways[J]. J Transl Med, 2023, 21( 1): 271. DOI: 10.1186/s12967-023-04104-8.
    [17]
    LIU HJ, GUAN QZ, ZHAO P, et al. TGF-β-induced CCR8 promoted macrophage transdifferentiation into myofibroblast-like cells[J]. Exp Lung Res, 2022: 1- 14. DOI: 10.1080/01902148.2022.2055227.
    [18]
    LI L, WEI W, LI ZZ, et al. The spleen promotes the secretion of CCL2 and supports an M1 dominant phenotype in hepatic macrophages during liver fibrosis[J]. Cell Physiol Biochem, 2018, 51( 2): 557- 574. DOI: 10.1159/000495276.
    [19]
    BARTNECK M, SCHRAMMEN PL, MÖCKEL D, et al. The CCR2+ macrophage subset promotes pathogenic angiogenesis for tumor vascularization in fibrotic livers[J]. Cell Mol Gastroenterol Hepatol, 2019, 7( 2): 371- 390. DOI: 10.1016/j.jcmgh.2018.10.007.
    [20]
    FLAMINI S, SERGEEV P, VIANA de BARROS Z, et al. Glucocorticoid-induced leucine zipper regulates liver fibrosis by suppressing CCL2-mediated leukocyte recruitment[J]. Cell Death Dis, 2021, 12( 5): 421. DOI: 10.1038/s41419-021-03704-w.
    [21]
    XI S, ZHENG X, LI X, et al. Activated hepatic stellate cells induce infiltration and formation of CD163+ macrophages via CCL2/CCR2 pathway[J]. Front Med(Lausanne). 2021, 8: 627927. DOI: 10.3389/fmed.2021.627927.
    [22]
    DU PLESSIS J, KORF H, van PELT J, et al. Pro-inflammatory cytokines but not endotoxin-related parameters associate with disease severity in patients with NAFLD[J]. PLoS One, 2016, 11( 12): e0166048. DOI: 10.1371/journal.pone.0166048.
    [23]
    XU L, CHEN YP, NAGASHIMADA M, et al. CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice[J]. Metabolism, 2021, 125: 154914. DOI: 10.1016/j.metabol.2021.154914.
    [24]
    GUO YK, ZHAO C, DAI WT, et al. C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape[J]. Int J Biol Sci, 2023, 19( 8): 2572- 2587. DOI: 10.7150/ijbs.83530.
    [25]
    IGAKI K, KOMOIKE Y, NAKAMURA Y, et al. MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model[J]. Int Immunopharmacol, 2018, 60: 160- 169. DOI: 10.1016/j.intimp.2018.04.049.
    [26]
    MORIKAWA R, NAKAMOTO N, AMIYA T, et al. Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis[J]. J Hepatol, 2021, 74( 3): 511- 521. DOI: 10.1016/j.jhep.2020.09.033.
    [27]
    HANSON A, PIRAS IS, WILHELMSEN D, et al. Chemokine ligand 20(CCL20) expression increases with NAFLD stage and hepatic stellate cell activation and is regulated by miR-590-5p[J]. Cytokine, 2019, 123: 154789. DOI: 10.1016/j.cyto.2019.154789.
    [28]
    HEO YJ, CHOI SE, LEE NM, et al. CCL20 induced by visfatin in macrophages via the NF-κB and MKK3/6-p38 signaling pathways contributes to hepatic stellate cell activation[J]. Mol Biol Rep, 2020, 47( 6): 4285- 4293. DOI: 10.1007/s11033-020-05510-7.
    [29]
    KISSELEVA T, BRENNER D. Molecular and cellular mechanisms of liver fibrosis and its regression[J]. Nat Rev Gastroenterol Hepatol, 2021, 18( 3): 151- 166. DOI: 10.1038/s41575-020-00372-7.
    [30]
    KONG M, DONG WH, KANG AQ, et al. Regulatory role and translational potential of CCL11 in liver fibrosis[J]. Hepatology, 2023, 78( 1): 120- 135. DOI: 10.1097/HEP.0000000000000287.
    [31]
    PROOST P, WUYTS A, van DAMME J. The role of chemokines in inflammation[J]. Int J Clin Lab Res, 1996, 26( 4): 211- 223. DOI: 10.1007/BF02602952.
    [32]
    TACKE F. Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo[J]. Fibrogenesis Tissue Repair, 2012, 5( Suppl 1): S27. DOI: 10.1186/1755-1536-5-S1-S27.
    [33]
    DEBES JD, ROMAGNOLI PA, PRIETO J, et al. Serum biomarkers for the prediction of hepatocellular carcinoma[J]. Cancers(Basel), 2021, 13( 7): 1681. DOI: 10.3390/cancers13071681.
    [34]
    ZHU MX, XU WY, WEI CY, et al. CCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis[J]. Cell Death Dis, 2019, 10( 11): 796. DOI: 10.1038/s41419-019-1966-6.
    [35]
    EHLING J, TACKE F. Role of chemokine pathways in hepatobiliary cancer[J]. Cancer Lett, 2016, 379( 2): 173- 183. DOI: 10.1016/j.canlet.2015.06.017.
    [36]
    YANG XQ, LU PR, FUJII C, et al. Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression[J]. Int J Cancer, 2006, 118( 8): 1869- 1876. DOI: 10.1002/ijc.21596.
    [37]
    PAN XF, CHIWANDA KAMINGA A, LIU AZ, et al. Chemokines in non-alcoholic fatty liver disease: A systematic review and network meta-analysis[J]. Front Immunol, 2020, 11: 1802. DOI: 10.3389/fimmu.2020.01802.
    [38]
    TAN YY, YUE SR, LU AP, et al. The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis[J]. Phytomedicine, 2022, 103: 154208. DOI: 10.1016/j.phymed.2022.154208.
    [39]
    RATZIU V, SANYAL A, HARRISON SA, et al. Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: Final analysis of the phase 2b CENTAUR study[J]. Hepatology, 2020, 72( 3): 892- 905. DOI: 10.1002/hep.31108.
    [40]
    WIERING L, TACKE F. Treating inflammation to combat non-alcoholic fatty liver disease[J]. J Endocrinol, 2022, 256( 1): e220194. DOI: 10.1530/JOE-22-0194.
    [41]
    PUENGEL T, LEFERE S, HUNDERTMARK J, et al. Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis[J]. Int J Mol Sci, 2022, 23( 12): 6696. DOI: 10.3390/ijms23126696.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(1)

    Article Metrics

    Article views (411) PDF downloads(37) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return