Advances in drug therapy for primary sclerosing cholangitis

Xia SHENG; Qingming JI; Xinyu LI; Lihong WANG; Junqi NIU

doi:10.12449/JCH240526

Volume 40 Issue 5

May 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(5): 1032-1038

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Advances in drug therapy for primary sclerosing cholangitis

DOI: 10.12449/JCH240526

Xia SHENG¹,
Qingming JI^b,
Xinyu LI^{b
,
,
,},
Lihong WANG^{4
,
,
,},
Junqi NIU^{c
,
,
,}

1a.
Department of Cadre Ward,The First Hospital of Jilin University Changchun 130021，China
1b.
Department of Critical Care Medicine,The First Hospital of Jilin University Changchun 130021，China
1c.
Department of Hepatology，Center of Infectious Diseases，The First Hospital of Jilin University，Changchun 130021，China
2.
Department of Endocrinology and Metabolic Diseases，The Second Affiliated Hospital of Harbin Medical University，Harbin 150000，China

Research funding:

National Natural Science Foundation of China (82200666)

More Information

Corresponding author: LI Xinyu， xinyuli@jlu.edu.cn （ORCID： 0000-0001-6215-4708）; WANG Lihong， whlhebykdx@163.com （ORCID： 0009-0009-6263-0028）; NIU Junqi， junqiniu@jlu.edu.cn （ORCID： 0000-0001-5415-2024）
Received Date: 2023-08-29
Accepted Date: 2023-10-30
Published Date: 2024-05-25

Abstract

Abstract

Primary sclerosing cholangitis （PSC） is a cholestatic disease characterized by chronic progressive bile duct inflammation and has a low incidence rate and poor prognosis in China. There is still no drug therapy that can change the course of PSC， and liver transplantation is the only effective treatment for PSC， with a 5-year survival rate of 85% after transplantation. Drug therapy for PSC is facing great challenges based on the current status of PSC. At present， drugs for the treatment of PSC are in the stage of clinical trials and have shown certain application prospect， among which ursodeoxycholic acid is the most widely studied and commonly used drug. In addition， there are many emerging drugs in the pipeline. This article summarizes the latest advances in drug therapy for PSC.
- Cholangitis， Sclerosing,
- Ursodeoxycholic Acid,
- Obecholic Acid,
- Drug Therapy

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References(41)

References

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Advances in drug therapy for primary sclerosing cholangitis

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