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Volume 40 Issue 5
May  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(5): 1021-1025

Hepatitis B vaccine： From prevention to treatment

DOI: 10.12449/JCH240524

  • First Department of Liver Disease Center，Beijing YouAn Hospital，Capital Medical University，Beijing 100069，China

Research funding:

National Key Research and Development Program of China (2023YFC2308100);

Capital Clinical Diagnostic Techniques and Translational Application Projects (Z211100002921059);

Beijing Hospitals Authority Youth Programme (QML20211702);

High-level Public Health Technical Talents Construction Project of Beijing Municipal Health Commission (Academic Leader -02-14)

More Information
  • Corresponding author: CHEN Xinyue， chenxydoc@ccmu.edu.cn （ORCID： 0000-0001-9569-4540）
  • Received Date: 2023-12-14
  • Accepted Date: 2024-02-01
  • Published Date: 2024-05-25
    Abstract
  • Hepatitis B vaccination is the most economical and effective way to prevent HBV infection. The advances in molecular biology and genetic engineering have continuously improved the manufacturing process of vaccines， and hepatitis B vaccine has gradually developed from the initial plasma-derived vaccine to the currently used recombinant vaccine. Preventive hepatitis B vaccine has been clinically tested in patients with HBsAg seroclearance to increase the level of anti-HBs， with certain safety and efficacy. As one of the multiple targets for new drugs in the treatment of chronic hepatitis B， a therapeutic hepatitis B vaccine based on HBsAg is already in the stages of research and development and clinical trial.

     

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