Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos（t）ide analogues and its treatment strategies

Rongjiong ZHENG; Xiaobo LU

doi:10.12449/JCH240506

Volume 40 Issue 5

May 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(5): 880-883

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Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos（t）ide analogues and its treatment strategies

DOI: 10.12449/JCH240506

Rongjiong ZHENG,
Xiaobo LU^{,
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Center of Infectious Diseases，The First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China

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Corresponding author: LU Xiaobo， xjykdluxiaobo@126.com （ORCID： 0000-0001-5532-7551）
Received Date: 2024-02-29
Accepted Date: 2024-03-30
Published Date: 2024-05-25

Abstract

Abstract

Highly effective oral antiviral therapy with low drug resistance can strongly inhibit HBV replication； however， some patients may still have low-level viremia （LLV） after receiving entecavir， tenofovir disoproxil fumarate， tenofovir alafenamide， or tenofovir amibufenamide for 48 weeks or more. Multiple studies in China and globally show that LLV after antiviral therapy is closely associated with the progression of chronic hepatitis B liver fibrosis， the risk of decompensated liver cirrhosis and hepatocellular carcinoma， and the reduction in long-term survival rate. Therefore， this article reviews the development， risk factors， and clinical harm of LLV after first-line treatment with nucleos（t）ide analogues， as well as different treatment regimens， in order to provide a reference for the treatment of LLV in chronic hepatitis B patients in the future.
- Hepatitis B， Chronic,
- Nucleosides,
- Nucleotides,
- Low-Level Viremia

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References(20)

References

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Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos（t）ide analogues and its treatment strategies

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Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos（t）ide analogues and its treatment strategies

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