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Volume 40 Issue 6
Jun.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(6): 1093-1099

Pathological diagnosis of cholestatic liver disease

DOI: 10.12449/JCH240605

  • Department of Pathology，Guangzhou KingMed Center for Clinical Laboratory，Guangzhou 510000，China

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  • Corresponding author: ZHANG Jiping， zjp-zhang@163.com（ORCID： 0009-0000-4878-4607）
  • Received Date: 2024-04-02
  • Accepted Date: 2024-05-14
  • Published Date: 2024-06-25
    Abstract
  • Cholestatic liver disease （CLD） is a group of liver diseases caused by various reasons， such as abnormal bile metabolism， blocked outflow， and bile duct injury， and the major causes of CLD include drugs， poisons， immunity， genetics， obstruction， infection， and tumor. Cholestasis is a common pathological change in CLD； however， the site， histopathology， and ultrastructure of cholestasis due to different etiologies are relatively specific. According to the etiology， this article elaborates on the pathological characteristics of CLD such as autoimmune cholangitis， inherited metabolic liver disease， and large bile duct disease and introduces the differential diagnosis of other types of CLD， in order to improve the understanding of CLD pathology and facilitate accurate diagnosis and treatment.

     

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