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Volume 40 Issue 6
Jun.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(6): 1269-1274

Regulatory effect of caveolin-1 in liver diseases

DOI: 10.12449/JCH240631

  • School of Basic Medical Sciences，Capital Medical University，Beijing 100069，China

Research funding:

General Project of Natural Science Foundation of Beijing (7222009)

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  • Corresponding author: SUN Quan， sunquan@ccmu.edu.cn （ORCID： 0000-0002-9367-3647）
  • Received Date: 2023-10-30
  • Accepted Date: 2023-12-22
  • Published Date: 2024-06-25
    Abstract
  • Caveolin-1 （CAV1） is a structural protein of caveolae on the plasma membrane and is an important regulatory factor for liver function. CAV1 regulates hepatic lipid deposition， lipid and glucose metabolism， mitochondrial function， and hepatocyte proliferation through various molecular pathways. Therefore， CAV1 plays a crucial role in maintaining liver physiology during the metabolic regulatory processes such as hepatic steatosis and hepatocyte proliferation. Furthermore， CAV1 is also involved in the development and progression of different types of liver injury， hepatitis， and liver cirrhosis. This article reviews the role of CAV1 in liver-related diseases and its mechanism in the regulation of liver macrophages， so as to provide a theoretical basis for targeting CAV1 in the treatment of liver-related diseases.

     

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