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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 6
Jun.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(6): 1169-1174

Efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in treatment of hepatocellular carcinoma

DOI: 10.12449/JCH240616

  • Department of Oncology，The First Hospital of Hebei Medical University，Shijiazhuang 050000，China

Research funding:

Medical Scientific Research Project of Hebei Provincial Health Commission (20210335)

More Information
  • Corresponding author: LI Na， lina19742000@sina.com （ORCID： 0009-0008-5561-900X）
  • Received Date: 2023-09-12
  • Accepted Date: 2023-10-27
  • Published Date: 2024-06-25
    Abstract
  •   Objective  To investigate the efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in the treatment of hepatocellular carcinoma （HCC）.  Methods  A total of 103 HCC patients who were admitted to our hospital from June 2020 to June 2023 were enrolled and randomly divided into combined treatment group with 53 patients and control group with 50 patients. The patients in the control group received percutaneous argon-helium cryoablation， and those in the combined treatment group received percutaneous argon-helium cryoablation combined with Camrelizumab monoclonal antibody. The two groups were compared in terms of short-term response， changes in T lymphocyte subsets after treatment， changes in liver function and alpha-fetoprotein （AFP） after treatment， and progression-free survival and overall survival during follow-up. The t-test was used for comparison of normally distributed continuous data between groups， and the chi-square test was used for comparison of categorical data between groups. The Kaplan-Meier method was used to plot survival curves， and the log-rank test was used for comparison of survival time between the two groups.  Results  The combined treatment group had significantly higher overall response rate and disease control rate than the control group （χ2=4.156 and 4.348， P=0.042 and 0.037）. After treatment， the combined treatment group had significant increases in the percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio （P<0.05） and a significant reduction in the percentage of CD8+ T lymphocytes （P<0.05）， while the control group had no significant changes in T lymphocyte subsets after treatment （P>0.05）， and compared with the control group after treatment， the combined treatment group had significantly higher percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio （all P<0.05） and a significantly lower percentage of CD8+ T lymphocytes （P<0.05）. After treatment， both groups had significant reductions in the levels of alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， and AFP （all P<0.05） and a significant increase in the level of albumin （Alb） （P>0.05）， and compared with the control group after treatment， the combined treatment group had significantly lower levels of ALT， AST， and AFP （all P<0.05） and a significantly higher level of Alb （P<0.05）. There were no significant differences in the incidence rates of grade Ⅲ‍—‍Ⅳ （moderate to severe） adverse reactions between the two groups （P>0.05）. Compared with the control group， the combined treatment group had significantly better median progression-free survival （21.32 months vs 15.31 months， χ2=4.689， P=0.030） and median overall survival （28.36 months vs 20.75 months， χ2=5.030， P=0.025）.  Conclusion  Argon-helium cryoablation combined with Camrelizumab monoclonal antibody can effectively improve short-term response， enhance immune function， and prolong survival time， with a favorable safety profile.

     

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    • References(21)
  • [1]
    RUMGAY H, ARNOLD M, FERLAY J, et al. Global burden of primary liver cancer in 2020 and predictions to 2040[J]. J Hepatol, 2022, 77( 6): 1598- 1606. DOI: 10.1016/j.jhep.2022.08.021.
    [2]
    WANG T, WANG CY, LIU JY, et al. Effectiveness and safety of ultrasound-guided ablation in treatment of primary liver cancer in dangerous areas[J]. J Clin Hepatol, 2021, 37( 7): 1594- 1598. DOI: 10.3969/j.issn.1001-5256.2021.07.023.

    王婷, 王春妍, 刘建勇, 等. 超声引导下局部消融治疗危险区域原发性肝癌的效果及安全性分析[J]. 临床肝胆病杂志, 2021, 37( 7): 1594- 1598. DOI: 10.3969/j.issn.1001-5256.2021.07.023.
    [3]
    MAO B, MA JD, DUAN SB, et al. Preoperative classification of primary and metastatic liver cancer via machine learning-based ultrasound radiomics[J]. Eur Radiol, 2021, 31( 7): 4576- 4586. DOI: 10.1007/s00330-020-07562-6.
    [4]
    ZHAI HG, XIAO ZH, YANG SL. Effect of CT-guided cryoablation with Argon-helium cryoablation on hepatic blood flow changes in primary liver cancer[J]. Chin J CT MRI, 2021, 19( 9): 96- 99, 110. DOI: 10.3969/j.issn.1672-5131.2021.09.030.

    翟焕阁, 肖正红, 杨双林. CT引导下氩氦刀冷冻消融术辅助治疗原发性肝癌对肿瘤组织血流变化的影响[J]. 中国CT和MRI杂志, 2021, 19( 9): 96- 99, 110. DOI: 10.3969/j.issn.1672-5131.2021.09.030.
    [5]
    LI X, MA LN, CHENG XZ, et al. Effect and safety of chemotherapy-based PD-1 inhibitors in the treatment of advanced lung adenocarcinoma[J]. J Pract Med, 2021, 37( 3): 365- 368. DOI: 10.3969/j.issn.1006-5725.2021.03.018.

    李兴, 马丽娜, 程小珍, 等. 基于化疗的PD-1抑制剂在晚期肺腺癌治疗中效果及安全性分析[J]. 实用医学杂志, 2021, 37( 3): 365- 368. DOI: 10.3969/j.issn.1006-5725.2021.03.018.
    [6]
    WANG Y, LUO D, LEI M, et al. Effect of silencing PD-1 gene on AAV8-mediated T cell immune response in HBV-infected rats[J]. Chin J Nosocomiology, 2021, 31( 17): 2584- 2588.

    王燕, 罗丹, 雷敏, 等. 沉默PD-1基因对AAV8介导的HBV感染大鼠T细胞免疫应答的影响[J]. 中华医院感染学杂志, 2021, 31( 17): 2584- 2588.
    [7]
    WEYKAMP F, HOEGEN P, REGNERY S, et al. Long-term clinical results of MR-guided stereotactic body radiotherapy of liver metastases[J]. Cancers(Basel), 2023, 15( 10): 2786. DOI: 10.3390/cancers15102786.
    [8]
    XU HC, WANG FL, XIE LH. Current status and perspectives in clinical treatment of intermediate and advanced primary hepatocellular carcinoma[J]. J Changchun Univ Chin Med, 2024, 40( 1): 103- 107. DOI: 10.13463/j.cnki.cczyy.2024.01.024.

    许华晨, 王凤玲, 谢林虎. 中晚期原发性肝细胞癌的临床治疗现状与展望[J]. 长春中医药大学学报, 2024, 40( 1): 103- 107. DOI: 10.13463/j.cnki.cczyy.2024.01.024.
    [9]
    LIU Y, ZHENG JX, HAO JL, et al. Global burden of primary liver cancer by five etiologies and global prediction by 2035 based on global burden of disease study 2019[J]. Cancer Med, 2022, 11( 5): 1310- 1323. DOI: 10.1002/cam4.4551.
    [10]
    LUO J, LYU CH, YANG YP. Clinical efficacy and safety of percutaneous cryoablation combined with percutaneous ethanol injection in elderly patients with hepatocellular carcinoma aged 70 years or older[J]. J Clin Hepatol, 2022, 38( 2): 365- 371. DOI: 10.3969/j.issn.1001-5256.2022.02.021.

    罗婧, 吕采红, 杨永平. 经皮冷冻消融联合无水酒精注射治疗70岁以上老年肝细胞癌患者的效果及安全性分析[J]. 临床肝胆病杂志, 2022, 38( 2): 365- 371. DOI: 10.3969/j.issn.1001-5256.2022.02.021.
    [11]
    JIN ZQ, LIU YX, LIANG M, et al. Comparison of efficacy and safety between cryoballoon ablation and radiofrequency catheter ablation in the treatment of paroxysmal atrial fibrillation[J]. Clin J Med Offic, 2021, 49( 10): 1079- 1082. DOI: 10.16680/j.1671-3826.2021.10.05.

    金志清, 刘艳霞, 梁明, 等. 冷冻球囊消融术与射频导管消融术治疗阵发性心房颤动疗效及安全性比较[J]. 临床军医杂志, 2021, 49( 10): 1079- 1082. DOI: 10.16680/j.1671-3826.2021.10.05.
    [12]
    MA JB, WANG FM, ZHANG WQ, et al. Percutaneous cryoablation for the treatment of liver cancer at special sites: An assessment of efficacy and safety[J]. Quant Imaging Med Surg, 2019, 9( 12): 1948- 1957. DOI: 10.21037/qims.2019.11.12.
    [13]
    DONNE R, LUJAMBIO A. The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma[J]. Hepatology, 2023, 77( 5): 1773- 1796. DOI: 10.1002/hep.32740.
    [14]
    MERELLI B, MASSI D, CATTANEO L, et al. Targeting the PD1/PD-L1 axis in melanoma: Biological rationale, clinical challenges and opportunities[J]. Crit Rev Oncol Hematol, 2014, 89( 1): 140- 165. DOI: 10.1016/j.critrevonc.2013.08.002.
    [15]
    HEINRICH S, CRAIG AJ, MA LC, et al. Understanding tumour cell heterogeneity and its implication for immunotherapy in liver cancer using single-cell analysis[J]. J Hepatol, 2021, 74( 3): 700- 715. DOI: 10.1016/j.jhep.2020.11.036.
    [16]
    FREEMAN GJ, LONG AJ, IWAI Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation[J]. J Exp Med, 2000, 192( 7): 1027- 1034. DOI: 10.1084/jem.192.7.1027.
    [17]
    TOPALIAN SL, HODI FS, BRAHMER JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer[J]. N Engl J Med, 2012, 366( 26): 2443- 2454. DOI: 10.1056/nejmoa1200690.
    [18]
    FINN RS, ZHU AX. Evolution of systemic therapy for hepatocellular carcinoma[J]. Hepatology, 2021, 73( Suppl 1): 150- 157. DOI: 10.1002/hep.31306.
    [19]
    CHEN EB, YI J, JIANG J, et al. Identification and validation of a fatty acid metabolism-related lncRNA signature as a predictor for prognosis and immunotherapy in patients with liver cancer[J]. BMC Cancer, 2022, 22( 1): 1037. DOI: 10.1186/s12885-022-10122-4.
    [20]
    LAI FT. Clinical efficacy and safety of carrizumab in the treatment of advanced primary liver cancer[J]. Shanxi Med J, 2021, 50( 15): 2269- 2272.

    赖奉庭. 卡瑞利珠单抗治疗晚期原发性肝癌临床效果及安全性研究[J]. 山西医药杂志, 2021, 50( 15): 2269- 2272.
    [21]
    LEE YY, LUO SC, LEE CH, et al. Optimizing tumor-associated antigen-stimulated autologous dendritic cell and cytokine-induced killer cell coculture to enhance cytotoxicity for cancer immunotherapy in manufacturing[J]. BMC Immunol, 2023, 24( 1): 14. DOI: 10.1186/s12865-023-00552-5.
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