Clinical analysis of 187 patients with autoimmune liver diseases

Objective To analyze the clinical, biochemical and immunological characteristics of autoimmune liver disease (AILD) .Methods The clinical, biochemical and immunological features of 187 patients with AILD were analyzed.Results AILD mainly affects 40 years old and older female patients.The clinical features are not typical.AIH is characterized by high γ-globulin, alanine aminotransferase (ALT) and immunoglobulin G, but PBC is characterized by high alkaline phosphatase (ALP) , γ-glutamy transpeptidase (GGT) and immunoglobubin M.AILD patients will combine with one or multiple CTD, SS is common, more than 30%.88% of patients with AILD presented significant titers of antinuclear antibody (ANA) , and the positive rate of AMA, AMA-M2 was 96.4% and 94.4% in PBC patients, respectively.AIH patients mainly treated with corticosteroid, and 46 receive UDCA monotherapy or a combination of UDCA and corticosteroid or immunosuppressive agents.Conclusion The patients with autoimmune liver diseases could be diagnosed by biochemical, immunological features and detection of autoantibodies.UDCA is effective in patients with AIH.