The significance of serum Anti-nuclear antibody level in Hepatitis B patients

Feng Hao; Yin GuoQing

Issue 2

Feb. 2010

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2010 > 26(2): 189-190+193

PDF( 171 KB)

The significance of serum Anti-nuclear antibody level in Hepatitis B patients

Published Date: 2010-02-20

Abstract

Abstract

Objective To study the relationship between serum antinuclear antibody (ANA) , liver function tests and HBVDNA during the different course of hepatitis B virus (HBV) infection.Methods 35 HBV carriers, 192 chronic hepatitis B (CHB) and 35 post-hepatitis B cirrhosis patients were included in the study.The ANA, liver function tests, and HBVDNA were measured.Results ANA was gradually increased in HBV carriers, chronic hepatitis B and cirrhosis patients.From 192 CHB patients, 29 (15.1%) were ANA positive.The levels of ALT, TB, ALB and HBVDNA were significantly higher in ANA positives than ANA negative patients (P<0.05) .Conclusion The serum level of ANA is correlated with disease course, HBVDNA replication and the degree of liver damage.
- anti-nuclear antibodies,
- hepatitis B,
- HBVDNA,
- liver function test

FullText(HTML)

References(7)

References

[1]Anna LZ, Alessia P, Carlo G.HBVand HCVchronic infection:Auto-immune manifestations and lymphoproliferation[J].Autoimmunity Reviews, 2008, 8 (2) :107-111.

[2]Patrice C, David S, Marc B, et al.Hepatitis B virus genotypes and extrahepaticmanifestations[J].J Hepatology, 2005, 43 (5) :764-770.

[3]陈瀑, 唐红, 宗华.乙型肝炎患者血清自身抗体检测研究[J].现代检验医学杂志, 2004, 19 (1) :25-26.

[4]李晓良, 杨大国, 林巧, 等.1335例慢性乙型肝炎患者血清自身抗体检测分析[J].中西医结合肝病杂志, 2006, 16 (3) :162-163.

[5] 中华医学会.病毒性肝炎防治方案[J].中华肝病杂志, 2000, 8 (5) :324-329.

[6]Naparstek Y, Plotz PH.The role of autoantibodies in autoimmune disease[J].ANNu Rev immunol, 1993, 11:79-104.

[7]刘胜勇, 张冬平, 李学军.抗平滑肌抗体、抗核抗体与慢性乙肝肝纤维化程度相关性研究[J].中国现代医生, 2008, 46 (3) :8-9.

Relative Articles

[1]	Liu JiaXiu, Xu Bin, Liu XingXiang, Li GuiZhen. Correlation between HBVDNA load and IFN-γ and IL-6 secreted by PMBC in patients with chronic hepatitis B [J]. Journal of Clinical Hepatology, 2010, 26(5): 510-512.
[4]	Su MingHua, Jiang JianNing, Zhou YuanPing, Chen MaoWei, Liu ZhiHong. Study of the relationship between BCP mutation in the hepatitis B virus gene and HBVDNA rebound after lamivudine therapy[J]. Journal of Clinical Hepatology, 2008, 24(3): 172-174.
[5]	Liu JianFang, Wang TieWu, Li YouPing, Zhang YuXi, Yang WanYong, Hu Yi. The relevance among HBV DNA in serum, in liver tissue and hepatitis indexes of patients with hepatitis B.[J]. Journal of Clinical Hepatology, 2008, 24(2): 86-87.
[6]	Wu FengTing, Lu: QiJun. Clinical relationships between cccDNA in sera with HBVDNA, YMDD mutants and hepatitis B relapse[J]. Journal of Clinical Hepatology, 2007, 23(5): 342-344.
[7]	Huang JunHua, You Jing, Chen HongYing, Gao HuiYun, Qu JunYan, Wu GuoBin. Analysis of liver histopathology in asymptomatic chronic HBV carriers[J]. Journal of Clinical Hepatology, 2007, 23(1): 6-8.
[9]	Zhang LeiJia, Zhang JinPing, Hu Bing. Relationship between Cytokines in children and HBV DNA in serum, hepatitis B virus markers.[J]. Journal of Clinical Hepatology, 2006, 22(1): 27-28.
[10]	Miao WeiLi, Zhang Jing. Analysing the change of HBV DNA in children with hepatitis B[J]. Journal of Clinical Hepatology, 2006, 22(1): 21-22.
[11]	Wu JianHua, Ruan QingFa, Lin Li, Ma XiaoJun. The relationship of serum HBVDNA levels and the expression of HBV antigen and the inflammation grade in liver tissues in the patients with chronic hepatitis B[J]. Journal of Clinical Hepatology, 2006, 22(1): 33-34.
[12]	Ding Hong, Lu ZhongHua, Jiang XiangHu. The relationship between the liver function and contents of serum HBVDNA and hepatic pathology in patiens with chronic hepatitis B.[J]. Journal of Clinical Hepatology, 2006, 22(3): 173-174.
[13]	Liu LongGen, Zhai DeFang, Liu JianHong, Qian MeiYun, Fang GuoPing. Researeh on the correlation between the contents of serum HBV DNA and liver function and liver tissue injury in hepatitis B patients.[J]. Journal of Clinical Hepatology, 2005, 21(1): 7-8.
[15]	Wu XiaoMan, Guo HaiBo. Detection and significance of interleukin 10 levels and HBVDNA in serums from patients with chronic hepatis B .[J]. Journal of Clinical Hepatology, 2004, 20(3): 151-152.
[16]	Shao Dong, Chen Ming, Wei Lai, Feng Xia, Liu ChengYuan. The realationship among activation-induced cell apoptosis of peripheral blood lymphocytes with the level of HBVDNA in the serum and Th1/Th2-type cytokins production in chronic hepatitis B virus infection patients[J]. Journal of Clinical Hepatology, 2004, 20(6): 339-340.
[17]	Cheng Peng, Gong Jun, Liu YingKe, Xu ZhiDe. Clinical distinguishing features in cirrhosis patients with positive antinuclear antibody.[J]. Journal of Clinical Hepatology, 2004, 20(3): 136-137.
[18]	Liu Wei, Zhao Wei, Luo Chan, Liu LanXia, Wang Lan. The primary study on the expression of HBcAg and HBVDNA in the liver tissues of the patients with hepatitis hepatocirrhosis of liver.[J]. Journal of Clinical Hepatology, 2002, 18(3): 173-174.

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (4251) PDF downloads(1697)

The significance of serum Anti-nuclear antibody level in Hepatitis B patients

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The significance of serum Anti-nuclear antibody level in Hepatitis B patients

Abstract

References

Relative Articles

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content