ALT正常的HBV慢性携带者肝组织病理结果分析

To investigate the influences of serum HBVDNA and HBeAg levels on the changes and clinic values of liver histopathology in asymptomatic chronic hepatitis B virus carriers (ASC) .The changes of liver were evaluated histopathologically in 32 ASC by transepidermal liver biopsy method.The liver tissue was dyed with haematoxylin-eosin (HE) staining for study of pathologic grading and staging of hepatic liver inflammation and fibrosis.HBV-markers were detected by enzymelinked immunosorbent assay (ELISA) method.Serum HBVDNA levels were measured by polymerase chain reaction (PCR) method.It can be concluded that ASC are not absolute equal to health carriers.Of 32 carriers, there are 15 persons with G1S0, 13 persons with G1S1, 4 persons with G2S1.The rate of pathologic grading and staging of hepatic liver inflammation and fibrosis was not significantly changes in 20 male carriers compared with 12 female carriers (P>0.05) .The rate of those in HBVDNA (+) carriers showed significant different from those of HBVDNA (-) carriers (P<0.05) .The rate of those in HBeAg (+) and high copy groups (HBVDNA>1.0×107cp/ml) carriers showed no significant difference from those of HBeAg (-) and low copy groups (HBVDNA<1.0×107cp/ml) respectively (P>0.05) .