氧化苦参碱联合二甲双胍对非酒精性脂肪肝患者胰岛素抵抗及血清TNFα的影响

To assess the therapeutic effect of oxymatrine combined with metformin on insulin resistance index and serum TNF-α in patients with non-alcoholic fatty liver.48 patients with non-alcoholic fatty liver were randomly divided into experiment group treated with oxymatrine combined with metformin (n=24) and control group treated with oxymatrine combined with vitamin c (n=24) for consecutive 4-6 months.Serum transaminaswe level (ALT, AST) , TNF-α, insulin resistance index (IRI) and liver/spleen CT index were detected before and after treatment respectively.All data were processed with statistics.The levels of serum ALT in experiment group were obviously reduced at the end point compared with those of control group (P<0.05) .The levels of IRI and serum TNF-alpha in experiment group were all significantly decreased at the end point compared with those of control group (P<0.05) .Meanwhile, liver/ spleen CT index in experiment group were obviously increased after treatment compared with that of control group (p<0.01) .And no severe side-effects occurred during the experiment.Oxymatrine combined with metformin was an effective and safe remedy for treating on non-alcoholic fatty liver.The mechanism might be related to the reduction of IRI and serum TNF-TNF-α.