The protective effect of oxymatrine on the fulminant hepatic failure in mice SIANG Xiao xing,

Xiang XiaoXing; Wang GuoJun; Cai Xiong; Li YuLi

Issue 2

Feb. 2000

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Article Navigation > Journal of Clinical Hepatology > 2000 > 16(2): 92-93

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氧化苦参碱对小鼠暴发型肝衰竭的保护作用

Published Date: 2000-02-20

Abstract

Abstract

The experiment aimed to study the protective effect and its mechanism of oxymatrine (OM) on the fulminant hepatic failure (FHF) induced by injecting lipopolysaccharide (LPS) in galactosamine (GalN) sensitized mice.Thirty mice were divided into three groups:OM group (100mgkg -1 d -1 ×3, ip) , model group and normal group.The serum levels of alanine aminotransferase (ALT) and tumor necrosis factor alpha (TNF α) in all mice were determined at 7.5 hours after injecting GaIN/LPS.At the same time, the liver tissues were takan for HE staining and the immunohistochemical detection of Fas and its ligand (FasL) .Results:The serum levels of ALT and TNF α in mice of OM group were decreased significantly than that of model group (P<0.05 and 0.01, respectively) .Both the degrees of liver injury and expression of Fas and FasL in mice of OM group were reduced obviously than that of model group (P<0.01) .Conclution:It is possible that OM blocks the hepatocyte apoptosis and necrosis induced by LPS through inhibiting the activity of TNF α and the expression of Fas and FasL in liver tissue.
- Oxymatrine,
- Lipopolysaccharide,
- Fulminant hepatic failure,
- Fas antigen,
- Fas ligand

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[]〔1〕胡振林 , 张俊平 , 余祥彬 , 等。苦参碱对脂多糖 /D 氨基半乳糖诱导的肝炎及离体巨噬细胞释放肿瘤坏死因子的影响 , 中国药理学报 , 1996, 17 ( 4 ) :3 5 1

[]〔2〕王俊学 , 王国俊 , 蔡雄 , 等。氧化苦参碱及甘草甜素对小鼠肝细胞凋亡的影响 , 第二军医大学学报 , 1999, 2 0 ( 4 ) :2 2 2

[]〔3〕VercammenD , BronckaertG , DeneckerG , etal.DualsignalingoftheFasreceptor:initiationofbothapoptoticandnecroticcelldeathpathways , JExpMed , 1998, 188 ( 5 ) :919

[]〔4〕胡瑾华 , 张玲霞 , 朱克顺 , 等。慢性乙型肝炎肝组织表达FasL蛋白、mRNA及Fas的实验研究 , 中华传染病杂志 , 1999, 17 ( 1) :18

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沈阳化工大学材料科学与工程学院沈阳 110142

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氧化苦参碱对小鼠暴发型肝衰竭的保护作用

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氧化苦参碱对小鼠暴发型肝衰竭的保护作用

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