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ISSN 2097-3497 (Online)
CN 22-1108/R
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2021 No.4
Theme Issue: Clinical diagnosis and treatment of complications related to liver failure
Executive Chief Editor: Xie Qing 
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
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Editorial
Paving the way to improve clinical management of acute-on-chronic liver failure using international criteria
Zhujun CAO, Chenxi ZHANG, Qing XIE
2021, 37(4): 745-751. DOI: 10.3969/j.issn.1001-5256.2021.04.001
Abstract(1534) HTML (378) PDF (3250KB)(245) Cited By (6)
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical disease significantly different from acute liver failure and acute decompensation of simple liver cirrhosis, and it may have acute progression to liver failure and failure of other organs. ACLF has a high short-term mortality rate and has become a ...
Discussions by experts
Research advances in liver failure associated with hepatitis B virus reactivation
Yu SHI, Min ZHENG
2021, 37(4): 752-756. DOI: 10.3969/j.issn.1001-5256.2021.04.002
Abstract(818) HTML (277) PDF (1908KB)(138) Cited By (6)
Abstract:
Hepatitis B virus (HBV) infection is a major public issue in the world. Although currently used antiviral drugs can effectively control virus replication, they cannot clear HBV and HBV reactivation is still observed after the withdrawal of anti-HBV drugs. Meanwhile, experimental studies and clinical...
Diagnosis and treatment of abdominal infection in patients with liver cirrhosis: Advances and challenges
Beiling LI, Jinjun CHEN
2021, 37(4): 757-760. DOI: 10.3969/j.issn.1001-5256.2021.04.003
Abstract(834) HTML (286) PDF (2213KB)(115) Cited By (9)
Abstract:
Infection is the most common complication in patients with end-stage liver disease, among which abdominal infection is the most common type. There is a low positive rate of ascitic fluid culture, and abdominal infection is mainly diagnosed based on multinucleated cell count in ascites and is mainly ...
Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future
Lei MIAO, Liangjie TANG, Jiangao FAN, Minghua ZHENG
2021, 37(4): 761-764. DOI: 10.3969/j.issn.1001-5256.2021.04.004
Abstract(835) HTML (217) PDF (1897KB)(131) Cited By (5)
Abstract:
Metabolic associated fatty liver disease (MAFLD) is a hotspot in the field of fatty liver disease at present and it has become the most common chronic liver disease around the world. It is predicted that the incidence rates of MAFLD and related liver cirrhosis will continue to grow in the next 20 ye...
Advances in the pathogenesis and treatment of acute-on-chronic liver failure
Dabao SHANG, Xiaogang XIANG
2021, 37(4): 765-769. DOI: 10.3969/j.issn.1001-5256.2021.04.005
Abstract(1571) HTML (775) PDF (1910KB)(232) Cited By (23)
Abstract:
Acute-on-chronic liver failure (ACLF) is a type of severe clinical syndrome which occurs on the basis of chronic liver diseases and has the main clinical features of acute liver decompensation, extrahepatic organ damage, and high short-term mortality rate. The underlying diseases of chronic liver di...
Nutritional assessment and clinical management of patients with acute-on-chronic liver failure
Muchen WU, Qinghua MENG
2021, 37(4): 770-774. DOI: 10.3969/j.issn.1001-5256.2021.04.006
Abstract(1107) HTML (195) PDF (1905KB)(129) Cited By (13)
Abstract:
As the most important visceral organ in human body for metabolism, the liver is an important place for the synthesis and storage of nutrients. Patients with acute-on-chronic liver failure suffer from varying degrees of malnutrition due to abnormal metabolism of various nutrients, and malnutrition mi...
Academic contention
Patients in the immune-tolerant phase of hepatitis B virus infection benefit a lot from antiviral therapy
Deyang WANG, Jun JIANG, Kekai ZHAO
2021, 37(4): 775-776. DOI: 10.3969/j.issn.1001-5256.2021.04.007
Abstract(516) HTML (183) PDF (1858KB)(101)
Abstract:
Active antiviral therapy should be given in the immune tolerance stage of hepatitis B virus infection
Jia SHANG
2021, 37(4): 777-777. DOI: 10.3969/j.issn.1001-5256.2021.04.008
Abstract(399) HTML (127) PDF (1841KB)(91)
Abstract:
Patients in the immune-tolerant phase of hepatitis B virus infection should receive antiviral therapy to reduce viral load
Bingliang LIN
2021, 37(4): 778-780. DOI: 10.3969/j.issn.1001-5256.2021.04.009
Abstract(410) HTML (140) PDF (1907KB)(75)
Abstract:
Patients in the immune-tolerant phase of chronic hepatitis B can receive antiviral therapy conditionally
Li XIAO, Jianchun XIAN
2021, 37(4): 781-782. DOI: 10.3969/j.issn.1001-5256.2021.04.010
Abstract(604) HTML (124) PDF (1864KB)(69)
Abstract:
Antiviral therapy is not recommended for patients in the immune-tolerant phase of hepatitis B virus infection
Minghui LI, Yao XIE
2021, 37(4): 783-784. DOI: 10.3969/j.issn.1001-5256.2021.04.011
Abstract(514) HTML (229) PDF (1865KB)(80)
Abstract:
Correction note on the estimated number of patients in the immune-tolerant phase of hepatitis B virus infection in China and globally
Hui ZHUANG
2021, 37(4): 785-786. DOI: 10.3969/j.issn.1001-5256.2021.04.012
Abstract(738) HTML (114) PDF (2087KB)(128) Cited By (18)
Abstract:
Guidelines
Consensus on imaging techniques and diagnostic criteria for hepatitis B virus related early hepatocellular carcinoma
Radiology of Infection Sub-branch, Radiology Branch, Chinese Medical Association, Committee on Radiology of Infection, Radiology Branch, Chinese Medical Doctor Association, Radiology Committee on Infectious and Inflammatory Disease, Chinese Research Hospital Association, Radiology of Infection Branch, Working and Treating Committee of HIV/AIDS and STD Association, Radiology of Infectious Disease Management Sub-branch, Infectious Disease Management Branch, Hospital Management Association in China, Beijing Imaging Diagnosis and Treatment Technology Innovation Alliance
2021, 37(4): 787-791. DOI: 10.3969/j.issn.1001-5256.2021.04.013
Abstract(849) HTML (364) PDF (4471KB)(207) Cited By (8)
Abstract:
The pathological diagnostic criteria for early hepatocellular carcinoma(eHCC)have been updated in 2009, but the imaging diagnostic criteria for eHCC have not yet been established by domestic or foreign academic organizations. Promoted by Radiology of Infection Sub-branch, Radiology Branch, Chinese M...
Expert consensus on the imaging diagnosis of hepatic echinococcosis
Radiology of Infection Sub-branch, Radiology Branch, Chinese Medical Association, Committee on Radiology of Infectious, Radiology Branch, Chinese Medical Doctor Association
2021, 37(4): 792-797. DOI: 10.3969/j.issn.1001-5256.2021.04.014
Abstract(480) HTML (417) PDF (2065KB)(91) Cited By (39)
Abstract:
Echinococcosis is a zoonotic disease with global distribution and has become an issue seriously affecting public health around the world. Imaging technology plays an important role in the early diagnosis, preoperative evaluation, and treatment outcome monitoring of hepatic echinococcosis. At present...
Chinese expert consensus on the endoscopic diagnosis and treatment of biliary fistula (2020, Beijing)
Chinese Society of Endoscopy, Chinese Medical Association, Endoscopic Physician Branch of Chinese Medical Doctor Association, Beijing Society of Digestive Endoscopy, Beijing Medical Association
2021, 37(4): 798-802. DOI: 10.3969/j.issn.1001-5256.2021.04.015
Abstract(459) HTML (253) PDF (1978KB)(141) Cited By (8)
Abstract:
Chinese expert consensus on the endoscopic diagnosis and treatment of pancreatic fistula (2020, Beijing)
Chinese Society of Endoscopy, Chinese Medical Association, Endoscopic Physician Branch of Chinese Medical Doctor Association, Beijing Society of Digestive Endoscopy, Beijing Medical Association
2021, 37(4): 803-808. DOI: 10.3969/j.issn.1001-5256.2021.04.016
Abstract(860) HTML (463) PDF (1955KB)(191) Cited By (8)
Abstract:
Original articles_Viral hepatitis
Association of gene mutations in the pre-C, C, and basic core promoter regions of hepatitis B virus with traditional Chinese medicine syndrome types
Dongfang SHANG, Shilei WANG, Wenxia ZHAO
2021, 37(4): 809-812. DOI: 10.3969/j.issn.1001-5256.2021.04.017
Abstract(566) HTML (186) PDF (1893KB)(36) Cited By (2)
Abstract:
Objective To investigate the association of gene mutations in the pre-C, C, and basic core promoter (BCP) regions of hepatitis B virus (HBV) with traditional Chinese medicine (TCM) syndrome types in patients with chronic hepatitis B (CHB). Methods A retrospective analysis was performed for the clini...
Original articles_Liver fibrosis and liver cirrhosis
Correlation of quality of life with aspartate aminotransferase-to-platelet ratio index, liver stiffness measurement, and histopathology after antiviral therapy for chronic hepatitis B liver fibrosis
Jing LU, Hongxin PIAO, Xuemei JIN, Jingshu CUI, Renshun JIN
2021, 37(4): 813-816. DOI: 10.3969/j.issn.1001-5256.2021.04.018
Abstract(714) HTML (288) PDF (1903KB)(75) Cited By (13)
Abstract:
Objective To investigate the correlation of quality of life (QOL) with aspartate aminotransferase-to-platelet ratio index (APRI), liver stiffness measurement (LSM), and histopathology after entecavir antiviral therapy for patients with chronic hepatitis B liver fibrosis. Methods A total of 95 patien...
Diagnostic value of FibroTouch, FibroScan, and acoustic radiation force impulse for liver fibrosis in patients with primary biliary cholangitis
Min WANG, Wenping LUO, Guanhua ZHANG, Xinyan ZHAO, Hong MA, Ying TIAN, Yu WANG
2021, 37(4): 817-822. DOI: 10.3969/j.issn.1001-5256.2021.04.019
Abstract(1001) HTML (458) PDF (2599KB)(109) Cited By (13)
Abstract:
Objective To investigate the diagnostic efficiency of FibroTouch, FibroScan, and acoustic radiation force impulse (ARFI) for liver fibrosis in patients with primary biliary cholangitis (PBC). Methods A retrospective analysis was performed for the patients who underwent liver biopsy and were then dia...
Original articles_Liver neoplasms
Construction and analysis of a predictive model for posthepatectomy recurrence in patients with hepatocellular carcinoma based on preoperative CXCL13 measurement
Mingwei LI, Jian GAO, Xiangwei ZHAI, Xiangjun QIAN, Xiajie WEN, Mingjie YAO, Zhaojun DUAN, Erjiang ZHAO, Ling ZHANG, Fengmin LU
2021, 37(4): 823-828. DOI: 10.3969/j.issn.1001-5256.2021.04.020
Abstract(694) HTML (257) PDF (2259KB)(45) Cited By (4)
Abstract:
Objective To investigate the serological markers associated with posthepatectomy recurrence in patients with hepatocellular carcinoma, and to establish a prognostic model to evaluate whether palliative hepatectomy is suitable for such patients. Methods A total of 111 patients with hepatocellular car...
Change in the activity of glucosylceramide synthase in human hepatoma cell line with hepatitis B virus infection in vitro
Jian GAN, Rui YANG, Chengcheng LEI, Yating YANG, Liting YAN, Aiping TIAN, Xiaorong MAO, Lili WANG, Junfeng LI
2021, 37(4): 829-833. DOI: 10.3969/j.issn.1001-5256.2021.04.021
Abstract(692) HTML (187) PDF (2434KB)(29) Cited By (1)
Abstract:
Objective To investigate the change in the activity of glucosylceramide synthase, the key enzyme in glycosphingolipid metabolism and synthesis, in Huh7 cells infected by hepatitis B virus (HBV) in vitro. Methods Blood samples were collected from nine previously untreated patients with acute hepatiti...
Original articles_Other liver diseases
A bioinformatics analysis of differentially expressed proteins in plasma exosome of acute-on-chronic liver failure patients with different prognoses
Yan JIAO, Ying ZHANG, Honglin SHI, Wang LU, Dexi CHEN, Yu CHEN, Hongbo SHI
2021, 37(4): 834-840. DOI: 10.3969/j.issn.1001-5256.2021.04.022
Abstract(838) HTML (233) PDF (4411KB)(59) Cited By (3)
Abstract:
Objective To investigate the differentially expressed proteins in the plasma exosome of acute-on-chronic liver failure (ACLF) patients with different prognoses, to analyze their functions and biological processes, and to provide a basis for clinical diagnosis. Methods A prospective study was perform...
Value of Fractalkine and soluble CD40 ligand in bile in predicting liver injury after liver transplantation
Pengxiang YANG, Yuxue GAO, Huan LIU, Yuntai SHEN, Yunjin ZANG, Dexi CHEN
2021, 37(4): 841-845. DOI: 10.3969/j.issn.1001-5256.2021.04.023
Abstract(414) HTML (134) PDF (2805KB)(30) Cited By (1)
Abstract:
Objective To investigate the value of cytokines in bile combined with clinical indices in predicting the degree of liver injury after liver transplantation. Methods A total of 16 patients undergoing liver transplantation who were hospitalized in Center of Organ Transplantation, The Affiliated Hospi...
Expression of ASBT and ASGPR mediated receptors for oral liver-targeting preparations in a rat model of hepatic alveolar echinococcosis
Ruixue GAO, Chunhui HU, Fabin ZHANG, Pan GAO, Xuehui GAN, Yaogang ZHANG, Bofan JIANG
2021, 37(4): 846-851. DOI: 10.3969/j.issn.1001-5256.2021.04.024
Abstract(773) HTML (177) PDF (3653KB)(34) Cited By (2)
Abstract:
Objective To investigate the feasibility of apical sodium-dependent bile salt transporter (ASBT) and asialoglycoprotein receptor (ASGPR) in the design of oral liver-targeting preparations for the treatment of hepatic alveolar echinococcosis (HAE) by measuring the expression of ASBT and ASGPR. Method...
Effect of macrophages on the differentiation of mouse induced pluripotent stem cells into hepatic progenitor cells
Tiantian GONG, Shaogang HUANG, Ruizhen SUN, Jingling SHEN, Qiuming LI, Lei LEI, Zhiyan SHAN
2021, 37(4): 852-856. DOI: 10.3969/j.issn.1001-5256.2021.04.025
Abstract(676) HTML (247) PDF (3026KB)(31)
Abstract:
Objective To investigate the effect of macrophages (MCs) on the differentiation of mouse induced pluripotent stem cells (iPSCs) into hepatic progenitor cells (HPCs). Methods A total of 24 C57BL/6N mice were used to obtain MCs by peritoneal irrigation, and the supernatant was collected to obtain the ...
Role of STAT3 in hepatocyte regeneration after acetaminophen-induced hepatocellular injury in mice
Wang YU, Lijiu ZHANG, Yan LU, Shasha SONG
2021, 37(4): 857-862. DOI: 10.3969/j.issn.1001-5256.2021.04.026
Abstract(1165) HTML (210) PDF (2009KB)(109) Cited By (7)
Abstract:
Objective To investigate the role of STAT3 in hepatocyte proliferation after acetaminophen (APAP)-induced hepatocellular injury in mice. Methods Normal mouse AML12 hepatocytes were cultured in vitro and were stimulated by APAP (1, 2.5, 5, 10, and 20 mmol/L) for 12, 24 or 48 hours, and the hepatocyte...
Original articles_Biliary diseases
Clinical effect of endoscopic nasobiliary drainage versus endoscopic biliary stenting in preoperative biliary drainage for low-level malignant obstructive jaundice: A Meta-analysis
Jincheng WANG, Peihe YU, Song SU, Bo LI
2021, 37(4): 863-867. DOI: 10.3969/j.issn.1001-5256.2021.04.027
Abstract(725) HTML (302) PDF (2745KB)(46) Cited By (12)
Abstract:
Objective To investigate the clinical effect and safety of endoscopic nasobiliary drainage (ENBD) versus endoscopic biliary stenting (EBS) in preoperative biliary drainage for low-level malignant obstructive jaundice. Methods Chinese and English databases were searched for control studies on the cli...
Value of nasobiliary cholangiography in the diagnosis of residual common bile duct stones after endoscopic retrograde cholangiopancreatography and related factors of residual common bile duct stones
Dapeng BIAN, Jinpei DONG, Haixia NIU, Yinmo YANG, Qiushi FENG
2021, 37(4): 868-871. DOI: 10.3969/j.issn.1001-5256.2021.04.028
Abstract(712) HTML (337) PDF (1889KB)(30) Cited By (13)
Abstract:
Objective To investigate the value of nasobiliary cholangiography in the diagnosis of residual common bile duct stones after endoscopic retrograde cholangiopancreatography (ERCP) and the risk factors for residual stones. Methods A retrospective analysis was performed for the clinical data of the pat...
Clinical effect of laparoscopy, choledochoscopy, and duodenoscopy combined with T-tube-free drainage in treatment of gallstones with common bile duct stones
Yunfeng WANG, Bin XU, Jie WANG, Wenzhong ZHANG, Gang LI, Jie LING, Wei QIU, Yueming WANG, Yongbing WANG
2021, 37(4): 872-876. DOI: 10.3969/j.issn.1001-5256.2021.04.029
Abstract(956) HTML (423) PDF (2486KB)(46) Cited By (71)
Abstract:
Objective To investigate the clinical effect of laparoscopy, choledochoscopy, and duodenoscopy combined with T-tube-free drainage in the treatment of gallstones with common bile duct stones. Methods A retrospective analysis was performed for the clinical data of 564 patients with gallstones and comm...
Original articles_Pancreatic diseases
Influencing factors for severe acute pancreatitis with sepsis
Chaoyun XIE, Ping ZHANG, Minkai WANG
2021, 37(4): 877-881. DOI: 10.3969/j.issn.1001-5256.2021.04.030
Abstract(772) HTML (234) PDF (1939KB)(50) Cited By (5)
Abstract:
Objective To investigate related factors for severe acute pancreatitis (SAP) with sepsis. Methods A retrospective analysis was performed for the clinical data of 178 SAP patients who were admitted from January 2007 to March 2020, and according to the presence or absence of sepsis, they were divided ...
Incidence rates of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting and related risk factors
Chen XU, Wei YANG, Jie GU, Weizhong ZHOU, Haibin SHI
2021, 37(4): 882-887. DOI: 10.3969/j.issn.1001-5256.2021.04.031
Abstract(997) HTML (358) PDF (2066KB)(31) Cited By (4)
Abstract:
Objective To investigate the clinical characteristics and risk factors of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting (PTBS). Methods A retrospective analysis was performed for the clinical data of 249 patients with malignant biliary obstruction who were a...
Clinical features and prognosis of autoimmune pancreatitis alone or with IgG4-related sclerosing cholangitis
Hang DING, Linlin ZHENG, Yuan LIU, Lianfeng ZHANG, Lin ZHOU
2021, 37(4): 888-892. DOI: 10.3969/j.issn.1001-5256.2021.04.032
Abstract(710) HTML (219) PDF (1979KB)(40) Cited By (7)
Abstract:
Objective To investigate the clinical features, diagnosis, treatment, and prognosis of autoimmune pancreatitis (AIP) alone versus AIP with IgG4 sclerosing cholangitis (IgG4-SC). Methods A retrospective analysis was performed for the clinical data of 40 patients with type 1 AIP who were admitted to T...
Risk factors for open pancreatic necrosectomy in patients with severe acute pancreatitis: An analysis based on the surgical step-up approach
Yuling DUAN, Zanjie FENG, Guoxin FAN, Lei WANG, Kangwei LIU, Cijun PENG
2021, 37(4): 893-897. DOI: 10.3969/j.issn.1001-5256.2021.04.033
Abstract(598) HTML (241) PDF (2166KB)(39) Cited By (5)
Abstract:
Objective To investigate the risk factors for open pancreatic necrosectomy (OPN), an effective treatment method for severe acute pancreatitis (SAP) after the failure of percutaneous catheter drainage (PCD), in patients with SAP. Methods A retrospective analysis was performed for 156 patients with SA...
Brief reports
Value of coronary-caval shunt combined with splenectomy in portal hypertension
Weijie WANG, Rongtao ZHU, Ruopeng LIANG, Jian LI, Chixian ZHANG, Dexu LI
2021, 37(4): 898-901. DOI: 10.3969/j.issn.1001-5256.2021.04.034
Abstract(462) HTML (108) PDF (4530KB)(26) Cited By (3)
Abstract:
Case reports
A case of acute hepatitis A with thrombocytopenia and hemolytic anemia
Lamei LI, Qi ZHU, Lin CHEN, Xinle YANG, Fang XU, Yanjun CAI, Junqi NIU, Wanyu LI
2021, 37(4): 902-904. DOI: 10.3969/j.issn.1001-5256.2021.04.035
Abstract(427) HTML (158) PDF (2360KB)(48) Cited By (1)
Abstract:
Death from acute hepatitis E in a non-pregnant middle-aged woman: A case report
Xiaotong XU, Jinglan JIN
2021, 37(4): 905-907. DOI: 10.3969/j.issn.1001-5256.2021.04.036
Abstract(435) HTML (123) PDF (1885KB)(39)
Abstract:
Ambroxol for treatment of liver cirrhosis and portal hypertension in Gaucher disease: A case report
Wei ZHANG, Shiyuan CUI, Shanshan WANG, Meifang ZHENG, Peng ZHANG, Runping GAO
2021, 37(4): 908-909. DOI: 10.3969/j.issn.1001-5256.2021.04.037
Abstract(868) HTML (222) PDF (1996KB)(82)
Abstract:
Congenital extrahepatic portosystemic shunt in adults: A report of three cases
Xiaoling ZHAO, Jimin ZHENG, Pingping LI, Yueqin LI
2021, 37(4): 910-913. DOI: 10.3969/j.issn.1001-5256.2021.04.038
Abstract(879) HTML (450) PDF (2248KB)(29) Cited By (1)
Abstract:
Hepatocellular carcinoma with constitutional indocyanine green excretory defect: A case report
Xuan QIU, Lijuan CHEN, Ying JIANG, Wei LIU
2021, 37(4): 914-915. DOI: 10.3969/j.issn.1001-5256.2021.04.039
Abstract(529) HTML (184) PDF (2262KB)(24) Cited By (1)
Abstract:
Misdiagnosis of hepatic encephalopathy caused by hepatic telangiectasia: A case report
An GAO, Shu ZHANG, Jianhe GAN, Dong LI
2021, 37(4): 916-917. DOI: 10.3969/j.issn.1001-5256.2021.04.040
Abstract(477) HTML (163) PDF (2098KB)(23)
Abstract:
Ampullary mixed neuroendocrine/non-neuroendocrine tumor: A case report
Yannan CAO, Yuelei HU, Guoyue LYU, Zhongqi FAN
2021, 37(4): 918-920. DOI: 10.3969/j.issn.1001-5256.2021.04.041
Abstract(679) HTML (186) PDF (2128KB)(24) Cited By (1)
Abstract:
Reviews
Association of hepatitis B and hepatitis C with type 2 diabetes mellitus
Chaomei QIN, Yongming LIU, Heling SU
2021, 37(4): 921-924. DOI: 10.3969/j.issn.1001-5256.2021.04.042
Abstract(735) HTML (223) PDF (2195KB)(61) Cited By (4)
Abstract:

Hepatitis B, hepatitis C, and type 2 diabetes mellitus (T2DM) are serious public health issues worldwide. This article analyzes the association of hepatitis B and hepatitis C with T2DM. The analysis shows that on the one hand, both hepatitis B and hepatitis C promote the pathogenesis of T2DM, which ...
Application of combined therapy with molecular-targeted drugs and immune checkpoint inhibitors and other combined therapies in hepatocellular carcinoma
Jingzhong OUYANG, Yanzhao ZHOU, Ruili ZHU, Zhengzheng WANG, Xun CHEN, Jinxue ZHOU, Qingjun LI
2021, 37(4): 925-930. DOI: 10.3969/j.issn.1001-5256.2021.04.043
Abstract(853) HTML (263) PDF (1932KB)(76) Cited By (8)
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its features of insidious onset, rapid development, and high recurrence bring great challenges to the long-term survival of HCC patients. Molecular-targeted drugs and immune checkpoint inhibitors have become the research ...
Mechanism of action of forkhead box transcription factors in hepatocellular carcinoma and their prospects as treatment targets
Tianyu LI, Huimin YAN
2021, 37(4): 931-934. DOI: 10.3969/j.issn.1001-5256.2021.04.044
Abstract(593) HTML (294) PDF (1910KB)(38) Cited By (5)
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers and has high incidence and mortality rates and poor prognosis. Forkhead box (FOX) transcription factor family can regulate cell growth, differentiation, and tissue development and plays an important role in tumor. This articl...
Pathogenesis and clinical translation of intrahepatic cholangiocarcinoma in the era of precision medicine
Wenhua YOU, Yuan LIANG, Ling LYU
2021, 37(4): 935-938. DOI: 10.3969/j.issn.1001-5256.2021.04.045
Abstract(1085) HTML (296) PDF (1903KB)(103) Cited By (10)
Abstract:

Intrahepatic cholangiocarcinoma (ICC) is an important liver malignancy next only to hepatocellular carcinoma, accounting for 15%-20% of primary liver cancer. In recent years, the incidence rate of ICC tends to increase globally; however, due to its insidious onset, high degree of malignancy, and str...
Effect of diet on enterotype-related gut microbiota in nonalcoholic fatty liver disease
Qiaohong LIU, Yu ZHAO, Yiyang HU
2021, 37(4): 939-942. DOI: 10.3969/j.issn.1001-5256.2021.04.046
Abstract(852) HTML (181) PDF (1913KB)(61) Cited By (8)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a typical chronic liver disease closely associated with gut dysbiosis, and dietary factor may be the most important driving factor affecting the composition and function of intestinal bacteria. Based on the concept of enterotype, this article summarizes th...
Research advances in metabolomics in nonalcoholic fatty liver disease
Yuting LUAN, Zhongming HUANG, Wenjuan SHEN, Minghao HA, Zhibing XU
2021, 37(4): 943-946. DOI: 10.3969/j.issn.1001-5256.2021.04.047
Abstract(968) HTML (1983) PDF (1902KB)(159) Cited By (11)
Abstract:
The incidence rate of nonalcoholic fatty liver disease (NAFLD) is gradually increasing, and NAFLD has become the most important chronic liver disease in China. At present, the pathogenesis of NAFLD has not been fully elucidated and there are still no effective drugs. From the perspectives of pathoge...
Research advances in medical treatment of metabolic associated fatty liver disease
Sutong LIU, Kaiqi SU, Chenlu ZHAO, Lihui ZHANG, Wenxia ZHAO
2021, 37(4): 947-950. DOI: 10.3969/j.issn.1001-5256.2021.04.048
Abstract(1078) HTML (196) PDF (1913KB)(124) Cited By (13)
Abstract:
Metabolic associated fatty liver disease (MAFLD) is currently one of the most important liver diseases worldwide, and its incidence rate is increasing year by year. This article summarizes the current research status of medical treatment of MAFLD, including lifestyle changes and individualized drug ...
Management of pruritus in primary biliary cholangitis
Kaili HU, Li XIAO
2021, 37(4): 951-954. DOI: 10.3969/j.issn.1001-5256.2021.04.049
Abstract(1208) HTML (296) PDF (1901KB)(107) Cited By (1)
Abstract:
Primary biliary cholangitis (PBC) is a progressive intrahepatic cholestatic autoimmune disease, and pruritus can be seen in 60%-70% of PBC patients and seriously affects patients' quality of life. Improving the symptoms of pruritus in PBC patients is of great significance for improving their quality...
Research status and challenges in the prognosis of primary biliary cholangitis after liver transplantation
Lin CHEN, Ning LIU, Jinglan JIN, Yanjun CAI, Fang XU, Junqi NIU, Wanyu LI
2021, 37(4): 955-958. DOI: 10.3969/j.issn.1001-5256.2021.04.050
Abstract(749) HTML (430) PDF (2063KB)(54) Cited By (1)
Abstract:
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with unknown etiology, and patients with poor response to ursodeoxycholic acid and obeticholic acid may eventually progress to liver cirrhosis and even liver failure. Liver transplantation is the only effective treatment method...
Role of Kupffer cells in the development and progression of primary biliary cholangitis
Haiyan FU, Yingmei TANG
2021, 37(4): 959-961. DOI: 10.3969/j.issn.1001-5256.2021.04.051
Abstract(748) HTML (161) PDF (1893KB)(37) Cited By (3)
Abstract:
The incidence rate of primary biliary cholangitis (PBC) is increasing year by year, but there is still no specific medicine at present and PBC has a complex pathogenesis. Kupffer cells, as the key cells involved in immunoregulation, play an important role in PBC. When hepatocytes are damaged, Kupffe...
Research advances in the pathogenesis of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
Wencheng LIU, Yan LI, Bing CHANG
2021, 37(4): 962-964. DOI: 10.3969/j.issn.1001-5256.2021.04.052
Abstract(742) HTML (180) PDF (1897KB)(57) Cited By (8)
Abstract:
Pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome (PA-HSOS) is a type of hepatic sinusoidal obstruction syndrome mainly caused by the intake of Chinese herbal medicine or food containing pyrrolizidine alkaloids. This article reviews the recent research advances in the mechanism ...
Research advances in hepatic echinococcosis with cavernous transformation of the portal vein
Maolin WANG, Yingmei SHAO
2021, 37(4): 965-968. DOI: 10.3969/j.issn.1001-5256.2021.04.053
Abstract(598) HTML (166) PDF (1899KB)(24) Cited By (2)
Abstract:
Compression by hepatic hydatid lesions may invade the portal vein and cause cavernous transformation of the portal vein (CTPV), which has difficulties and high risks in surgery, and conventional hepatectomy cannot achieve radical treatment. This article reviews the etiology, classification, clinical...
Effect of hypothyroidism on chronic liver diseases
Huan LIU, Peng CHEN, Fei LI
2021, 37(4): 969-972. DOI: 10.3969/j.issn.1001-5256.2021.04.054
Abstract(675) HTML (449) PDF (2065KB)(56) Cited By (3)
Abstract:
The liver plays an important role in the metabolism, degradation, and excretion of thyroid hormones in the normal physiological state; however, when liver injuries occur, there is a significance increase in hypothyroidism, and most patients have no obvious clinical symptoms or signs. The article sum...
Mechanism of action of suppressor of cytokine signaling 1 in the development and progression of liver inflammatory diseases
Xia WU, Xiaoning ZHU, Yurong ZHANG, Yue YIN, Mengyun PENG, Ding ZHENG, Jing WANG
2021, 37(4): 973-976. DOI: 10.3969/j.issn.1001-5256.2021.04.055
Abstract(630) HTML (607) PDF (2499KB)(29) Cited By (5)
Abstract:
The development of liver inflammatory diseases is associated with autoimmunity and inflammatory response. As a negative feedback regulator of cell signal, suppressor of cytokine signaling 1 (SOCS1) plays a key role in the development and progression of inflammatory diseases. This article mainly intr...
Research advances in the role of lymphocyte activation gene-3 in liver-related diseases
Rui CHEN, Zhixin WANG, Haining FAN, Haijiu WANG
2021, 37(4): 977-981. DOI: 10.3969/j.issn.1001-5256.2021.04.056
Abstract(704) HTML (139) PDF (1923KB)(38) Cited By (1)
Abstract:
Immune checkpoint inhibitors (ICIs) therapy has shown broad prospects in the treatment of malignant tumors and infectious diseases, but problems encountered during application drive researchers to explore potential immune checkpoints. This article summarizes the research advances in the role of the ...
Research advances in pancreatic exocrine insufficiency secondary to pancreatic cancer
Chenguang SHI, Xiaohuan LIU, Yaxing XIE, Yanbo MA
2021, 37(4): 982-984. DOI: 10.3969/j.issn.1001-5256.2021.04.057
Abstract(704) HTML (302) PDF (2047KB)(41) Cited By (10)
Abstract:
At present, there is still a lack of comprehensive diagnosis and treatment criteria for pancreatic exocrine insufficiency around the world. Pancreatic surgeons often ignore or misjudge pancreatic exocrine insufficiency secondary to pancreatic cancer, and as a result, pancreatic exocrine insufficienc...
    

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