Incidence rates of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting and related risk factors

Chen XU; Wei YANG; Jie GU; Weizhong ZHOU; Haibin SHI

doi:10.3969/j.issn.1001-5256.2021.04.031

Volume 37 Issue 4

Apr. 2021

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Incidence rates of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting and related risk factors

DOI: 10.3969/j.issn.1001-5256.2021.04.031

Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Received Date: 2020-09-15
Accepted Date: 2020-11-23
Published Date: 2021-04-20

Abstract

Abstract

Objective To investigate the clinical characteristics and risk factors of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting (PTBS). Methods A retrospective analysis was performed for the clinical data of 249 patients with malignant biliary obstruction who were admitted to Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, and underwent PTBS from March 2016 to February 2020, and according to the presence or absence of postoperative hyperamylasemia or acute pancreatitis, the patients were divided into two groups to analyze incidence rate, severity, and related risk factors. The t-test or the Mann-Whitney U test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. A multivariate logistic regression analysis was performed for the factors with P < 0.1 in the univariate analysis to investigate independent risk factors for hyperamylasemia and acute pancreatitis after PTBS. Results After PTBS, 55 patients (22.1%) patients had abnormally elevated serum amylase, among whom 26 (10.4%) were diagnosed with hyperamylasemia and 29 (11.7%) were diagnosed with acute pancreatitis. All patients with acute pancreatitis had mild manifestations. The multivariate logistic regression analysis showed that age ≤60 years (odds ratio [OR]=2.2, 95% confidence interval [CI]: 1.07-4.52, P=0.033), iodine-125 seed strand implantation (OR=2.8, 95%CI: 1.21-6.45, P=0.016), biliary stent placement across the papilla (OR=6.3, 95%CI: 2.85-14.05, P < 0.001), and visualization of the pancreatic duct during surgery (OR=13.9, 95%CI: 5.64-34.03, P < 0.001) were risk factors for hyperamylasemia and acute pancreatitis after PTBS. Conclusion Hyperamylasemia and acute pancreatitis are relatively common complications after PTBS. Age ≤60 years, iodine-125 seed strand implantation, biliary stent placement across the papilla, and visualization of the pancreatic duct during surgery are independence risk factors for hyperamylasemia and acute pancreatitis after PTBS.
- Hyperamylasemia,
- Pancreatitis,
- Risk Factors

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Incidence rates of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting and related risk factors

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Incidence rates of hyperamylasemia and acute pancreatitis after percutaneous transhepatic biliary stenting and related risk factors

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