Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future

Lei MIAO; Liangjie TANG; Jiangao FAN; Minghua ZHENG

doi:10.3969/j.issn.1001-5256.2021.04.004

Volume 37 Issue 4

Apr. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(4): 761-764

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Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future

DOI: 10.3969/j.issn.1001-5256.2021.04.004

Lei MIAO^{1, 2},
Liangjie TANG¹,
Jiangao FAN^{3, 4
,
,},
Minghua ZHENG^{1, 5, 6
,
,}

1.
NAFLD Research Center/Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
2.
Department of Gastroenterology, Yuying Children's Hospital, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
3.
Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
4.
Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
5.
Institute of Hepatology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
6.
Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang 325000, China

Research funding:

(81500665);

(82070588);

(S2032102600032);

Received Date: 2020-12-20
Accepted Date: 2021-01-05
Published Date: 2021-04-20

Abstract

Abstract

Metabolic associated fatty liver disease (MAFLD) is a hotspot in the field of fatty liver disease at present and it has become the most common chronic liver disease around the world. It is predicted that the incidence rates of MAFLD and related liver cirrhosis will continue to grow in the next 20 years and that they will become new global health issues. Acute-on-chronic liver failure (ACLF) is defined as a clinical syndrome of acute or subacute liver function decompensation within a short period of time in the presence of existing chronic liver diseases, with the main clinical manifestations of ascites, jaundice, coagulation disorder, and hepatic encephalopathy. Based on the existing data, this article discusses the epidemiology, pathogenesis, treatment and management strategies, and future prospects of MAFLD-ACLF.
- Metabolic Associated Fatty Liver Disease,
- Acute-On-Chronic Liver Failure,
- Liver Transplantation

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References(34)

References

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Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future

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Acute-on-chronic liver failure in patients with metabolic associated fatty liver disease: Past, Present, and Future

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