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ISSN 2097-3497 (Online)
CN 22-1108/R
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2021 No.3
Theme Issue: Ablation of liver tumor
Executive Chief Editor: Li Xiao 
Cancer Hospital of Chinese Academy of Medical Sciences
Cover Content

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Editorial
Management of ablation techniques for liver cancer and establishment of a diverse team for liver cancer ablation
Yan FU, Xiao LI, Xiaowu ZHANG, Jiawei CAO
2021, 37(3): 497-500. DOI: 10.3969/j.issn.1001-5256.2021.03.001
Abstract(724) HTML (291) PDF (1872KB)(90)
Abstract:
Ablation is one of the important treatment methods for liver cancer, and standard ablation techniques, scientific and rational therapeutic strategy, and close teamwork are important premises for a good clinical effect. Although the efficacy of ablation therapy for liver cancer has gradually increase...
Discussions by experts
Ablation therapy for large hepatocellular carcinoma
Fei CAO, Weijun FAN
2021, 37(3): 501-505. DOI: 10.3969/j.issn.1001-5256.2021.03.002
Abstract(875) HTML (247) PDF (1817KB)(108)
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, and when a single tumor is larger than 5 cm in diameter, it is defined as large HCC. Large HCC has the characteristics of high degree of tumor malignancy and high risk of tumor metastasis and vascular invasion, which...
Local treatment of liver cancer: Ablation or resection?
Yaoping SHI, Bo ZHAI
2021, 37(3): 506-509. DOI: 10.3969/j.issn.1001-5256.2021.03.003
Abstract(618) HTML (338) PDF (1800KB)(90)
Abstract:
Liver cancer is one of the most common malignant tumors in China. Surgical resection is still the preferred radical treatment method for patients with liver cancer; however, most patients cannot tolerate surgical resection due to the influence of tumor size, tumor location, liver function, and gener...
Current status and advances in ultrasound-guided thermal ablation for hepatocellular carcinoma
Xin LI, Ping LIANG
2021, 37(3): 510-514. DOI: 10.3969/j.issn.1001-5256.2021.03.004
Abstract(1422) HTML (276) PDF (1971KB)(127)
Abstract:
Hepatocellular carcinoma (HCC) is a common malignant tumor in clinical practice, and image-guided thermal ablation is a radical treatment method for early-stage HCC and a method for palliative tumor reduction and combination with systematic therapy for advanced HCC. With the advantages of real-time ...
Advances in local ablation therapy for liver cancer with portal hypertension
Wen LUO, Jun TIE
2021, 37(3): 515-521. DOI: 10.3969/j.issn.1001-5256.2021.03.005
Abstract(784) HTML (157) PDF (1871KB)(79)
Abstract:
With the comprehensive application of a variety of treatment methods, the survival time of patients with primary liver cancer is gradually increasing. For patients with early-stage liver cancer and portal hypertension, local ablation therapy can achieve long-term survival and play a positive role in...
Stereotactic ablative radiotherapy for colorectal cancer liver metastasis
Xuemin LI, Hao WANG, Junjie WANG
2021, 37(3): 522-526. DOI: 10.3969/j.issn.1001-5256.2021.03.006
Abstract(812) HTML (435) PDF (1818KB)(57)
Abstract:
Systemic treatment and local treatment of metastatic lesion can improve the survival of patients with colorectal cancer liver metastasis (CRLM). Stereotactic body radiotherapy, also known as stereotactic ablative radiotherapy (SABR), is an effective method for local treatment of metastatic lesion an...
Guidelines
Management algorithm for prevention of mother-to-child transmission of hepatitis B virus(2021)
Chinese Foundation for Hepatitis Prevention and Control, Chinese Society of Infectious Diseases, Chinese Medical Association, Chinese Society of Hepatology, Chinese Medical Association
2021, 37(3): 527-531. DOI: 10.3969/j.issn.1001-5256.2021.03.007
Abstract(1668) HTML (1081) PDF (2202KB)(824)
Abstract:
Consensus on the secondary prevention for primary liver cancer (2021 edition)
Chinese Society of Hepatology, Chinese Medical Association
2021, 37(3): 532-542. DOI: 10.3969/j.issn.1001-5256.2021.03.008
Abstract(1859) HTML (343) PDF (3779KB)(664)
Abstract:
In order to standardize the effective prevention, early screening, and diagnosis of primary liver cancer, Chinese Society of Hepatology, Chinese Medical Association, organized relevant experts to develop consensus on the secondary prevention for primary liver cancer (2021 edition) based on the advan...
China guideline for diagnosis and comprehensive treatment of colorectal liver metastases (2020 edition)
Chinese College of Surgeons, Chinese Medical Doctor Association, Chinese Society Gastrointestinal Surgery, Chinese Society of Surgery, Chinese Medical Association, Chinese Society of Colorectal Surgery, Chinese Society of Surgery, Chinese Medical Association, Section of Colorectal Oncology, Chinese Society of Oncology, Chinese Medical Association, Colorectal Cancer Professional Committee, Chinese Anti-Cancer Association, Colorectal Cancer Professional Committee, Chinese Medical Doctor Association, Colorectal Cancer Expert Committee, Chinese Society of Clinical Oncology, Chinese College of Colorectal Surgeons, Chinese College of Surgeons, Chinese Medical Doctor Association, Metastasis Research Committee, Anorectal Branch of Chinese Medical Doctor Association, Colorectal Liver Metastases Professional Committee, China International Exchange and Promotive Association for Medical and Health Care
2021, 37(3): 543-553. DOI: 10.3969/j.issn.1001-5256.2021.03.009
Abstract(2405) HTML (244) PDF (2560KB)(485)
Abstract:
An excerpt of WGO guidance for the care of patients with COVID-19 and liver disease
Zhe LI, Fangbo GAO, Yanyan WU, Xingshun QI
2021, 37(3): 554-555. DOI: 10.3969/j.issn.1001-5256.2021.03.010
Abstract(673) HTML (109) PDF (1929KB)(49)
Abstract:
Original articles_Viral hepatitis
Influencing factors for low-level viremia in chronic hepatitis B patients treated with long-term entecavir antiviral therapy
He CHEN, Juanjuan FU, Li LI, Guangde YANG, Xiucheng PAN
2021, 37(3): 556-559. DOI: 10.3969/j.issn.1001-5256.2021.03.011
Abstract(910) HTML (503) PDF (1808KB)(152)
Abstract:
Objective To investigate the influencing factors for persistent low-level viremia (LLV) in chronic hepatitis B(CHB) patients receiving long-term entecavir antiviral therapy. Methods The CHB patients who received entecavir antiviral therapy for at least one year in The Affiliated Hospital of Xuzhou M...
Role of coagulation abnormalities in thrombosis in patients with hepatitis B virus-associated acute-on-chronic liver failure
Ying XU, Xiaoping HUANG, Li CHEN, Wei SUN, Yan WANG, Jianhe GAN
2021, 37(3): 560-564. DOI: 10.3969/j.issn.1001-5256.2021.03.012
Abstract(659) HTML (193) PDF (1915KB)(75)
Abstract:
Objective To investigate the role of coagulation function parameters and platelet indices in thrombotic events in patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods A total of 56 patients with HBV-ACLF who were hospitalized in The First Affiliated Hospital ...
Clinical features and risk factors of acute hepatitis E with severe jaundice
Yu LIU, Xue MEI, Yuyi ZHANG, Ying ZOU, Zhengguo ZHANG, Hongying GUO, Wei YUAN, Jiefei WANG, Zhiping QIAN
2021, 37(3): 565-569. DOI: 10.3969/j.issn.1001-5256.2021.03.013
Abstract(668) HTML (163) PDF (1946KB)(60)
Abstract:
Objective To investigate the clinical features of acute hepatitis E (AHE) patients with or without severe jaundice and the risk factors for severe jaundice. Methods A retrospective analysis was performed for the clinical data of 179 AHE patients who were admitted to Shanghai Public Health Clinical C...
Original articles_Liver fibrosis and liver cirrhosis
Value of common clinical indices and noninvasive liver fibrosis scores in the diagnosis of advanced liver fibrosis in hepatic-type Wilson's disease in China
Chen LIANG, Hui LIU, Jie BAI, Yan REN, Tailing WANG, Nianchen LIU, Li BAI, Shuang LIU, Yu CHEN, Zhongping DUAN, Sujun ZHENG
2021, 37(3): 570-574. DOI: 10.3969/j.issn.1001-5256.2021.03.014
Abstract(708) HTML (375) PDF (2262KB)(67)
Abstract:
Objective To investigate the association of common clinical indices and noninvasive liver fibrosis scores with hepatic-type Wilson's disease (WD) in Chinese patients and their ability to identify advanced liver fibrosis. Methods A retrospective analysis was performed for the clinical data of 236 Chi...
Mechanism of action of Xiayuxue decoction in inhibiting liver fibrosis by regulating glial cell line-derived neurotrophic factor
Wei ZHANG, Guangyue YANG, Dongxiao SHEN, Wenting MA, Le TAO, Liu WU, Ping YAN, Cheng LIU
2021, 37(3): 575-581. DOI: 10.3969/j.issn.1001-5256.2021.03.015
Abstract(1093) HTML (628) PDF (2815KB)(66)
Abstract:
Objective To investigate whether Xiayuxue decoction exerts an anti-liver fibrosis effect by inhibiting glial cell line-derived neurotrophic factor (GDNF). Methods A total of 24 C57BL/6 mice were randomly divided into control group, model group, and Xiayuxue decoction group. The mice in the model gro...
Mechanism of Xiaozheng Huoluo prescription in preventing liver fibrosis in rats via the ERK5 pathway: An analysis based on network pharmacology
Le TIAN, Yinghang WANG, Zhi PAN
2021, 37(3): 582-589. DOI: 10.3969/j.issn.1001-5256.2021.03.016
Abstract(619) HTML (263) PDF (5010KB)(34)
Abstract:
Objective To investigate the mechanism of Xiaozheng Huoluo prescription (XZHLF) in the prevention and treatment of liver fibrosis based on network pharmacology. Methods TCMSP database, Chemistry Database, ETCM database, chemical source network database, ChemSrc database, and PubChem database were se...
Value of albumin-bilirubin score in predicting the prognosis of cirrhotic patients with esophagogastric variceal bleeding
Mengyuan SUN, Xiaoxing XIANG
2021, 37(3): 590-594. DOI: 10.3969/j.issn.1001-5256.2021.03.017
Abstract(923) HTML (523) PDF (2118KB)(100)
Abstract:
Objective To investigate the value of albumin-bilirubin (ALBI) score in predicting the prognosis of cirrhotic patients with esophagogastric variceal bleeding, and to identify risk stratification and increase clinical applicability. Methods A retrospective analysis was performed for the clinical data...
Clinical effect of laparoscopic splenectomy and pericardial devascularization in portal hypertension patients with Child-Pugh A/B liver function
Changxu LI, Luyao XU, Na RU, Xuekang REN, Chaohui TANG, Yingchao WANG
2021, 37(3): 596-600. DOI: 10.3969/j.issn.1001-5256.2021.03.018
Abstract(571) HTML (145) PDF (1806KB)(39)
Abstract:
Objective To investigate the clinical effect of laparoscopic splenectomy and pericardial devascularization (LSPD) in patients with portal hypertension and the long-term effect of LSPD. Methods A total of 40 portal hypertension patients with Child-Pugh A/B liver function who received LSPD in The Firs...
Original articles_Liver neoplasms
Effect of entecavir antiviral therapy on the prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after transcatheter arterial chemoembolization
Weimeng HE, Zhiming ZHANG, Jinlin HOU, Yajing HE
2021, 37(3): 601-605. DOI: 10.3969/j.issn.1001-5256.2021.03.019
Abstract(484) HTML (172) PDF (2406KB)(41)
Abstract:
Objective To investigate the effect of entecavir (ETV) antiviral therapy on the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) receiving transcatheter arterial chemoembolization (TACE). Methods A total of 170 HCC patients who received TACE for the first tim...
Clinical effect of programmed cell death-1 inhibitor combined with lenvatinib in treatment of advanced primary liver cancer and related adverse events
Ying TENG, Xiaoyan DING, Wendong LI, Jinglong CHEN
2021, 37(3): 606-610. DOI: 10.3969/j.issn.1001-5256.2021.03.020
Abstract(1002) HTML (349) PDF (1942KB)(73)
Abstract:
Objective To investigate the clinical effect of domestic programmed cell death-1 (PD-1) inhibitor combined with lenvatinib in the treatment of advanced primary liver cancer and related adverse events. Methods A retrospective analysis was performed for the clinical data of 24 patients with advanced p...
Clinical effect of transcatheter arterial chemoembolization in treatment of patients with hepatocellular carcinoma and portal vein tumor thrombus and an analysis of prognostic evaluation models
Qiaoyi YANG, Enxin WANG, Zhexuan WANG, Dongdong XIA, Wei BAI, Xiaomei LI, Guohong HAN
2021, 37(3): 611-615. DOI: 10.3969/j.issn.1001-5256.2021.03.021
Abstract(816) HTML (240) PDF (2117KB)(52)
Abstract:
Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) in the treatment of patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus and the value of existing prognostic evaluation models for HCC. Methods Screening was performed for HCC pati...
Value of Modified Response Evaluation Criteria in Solid Tumors response in predicting the prognosis of patients with unresectable hepatocellular carcinoma patients after transarterial chemoembolization
Dandan HAN, Zhexuan WANG, Enxin WANG, Dongdong XIA, Qiuhe WANG, Wei BAI, Yong CHEN, Guohong HAN
2021, 37(3): 616-620. DOI: 10.3969/j.issn.1001-5256.2021.03.022
Abstract(1238) HTML (382) PDF (1927KB)(47)
Abstract:
Objective To investigate the association of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) response with the prognosis of patients with unresectable hepatocellular carcinoma (HCC) after transarterial embolization (TACE). Methods A retrospective analysis was performed for the clinica...
Influence of high-density lipoprotein cholesterol on the prognosis of patients with alcohol-related hepatocellular carcinoma after radical treatment
Rui ZHANG, Xiujuan CHANG, Jiamin CHENG, Zhiqin ZHAO, Yinyin LI, Yinying LU, Zhen ZENG
2021, 37(3): 621-626. DOI: 10.3969/j.issn.1001-5256.2021.03.023
Abstract(594) HTML (108) PDF (1860KB)(21)
Abstract:
Objective To investigate the association of high-density lipoprotein cholesterol (HDL-C) with the prognosis of patients with alcohol-related hepatocellular carcinoma (HCC) after radical treatment. Methods A retrospective analysis was performed for the clinical data of 43 patients with alcohol-relate...
Original articles_Other liver diseases
Relationship between vitamin D level in children and adolescents with nonalcoholic fatty liver disease: A Meta-analysis
Tingpeng HU, Sudan TANG, Zebo YU
2021, 37(3): 627-631. DOI: 10.3969/j.issn.1001-5256.2021.03.024
Abstract(700) HTML (178) PDF (2011KB)(50)
Abstract:
Objective To systematically evaluate the association between vitamin D level and nonalcoholic fatty liver disease (NAFLD) in children and adolescents. Methods Related English and Chinese databases, including PubMed, Cochrane Library, Embase, CNKI, CBM, Wanfang Data, and VIP, were searched for studie...
Clinical features of patients with different types of acute drug-induced liver injury: A comparative analysis
Yu WANG, Lixia QIU, Zuopeng FAN, Jingjing SONG, Jing ZHANG, Yutao ZHAN
2021, 37(3): 632-635. DOI: 10.3969/j.issn.1001-5256.2021.03.025
Abstract(712) HTML (150) PDF (1808KB)(87)
Abstract:
Objective To investigate the clinical features of patients with different types of acute drug-induced liver injury (DILI) through a retrospective analysis. Methods Clinical data were collected from 790 patients who were diagnosed with acute DILI in Beijing YouAn Hospital and Beijing Tongren Hospital...
Features of liver injury in adolescents and adults with infectious mononucleosis: A single-center retrospective clinical study of 274 cases
Yanan FAN, Yiyi SHI, Jinghang XU, Niuniu LI, Ran CHENG, Lixia QIN, Tongtong JI, Xueying LI, Yanyan YU
2021, 37(3): 636-640. DOI: 10.3969/j.issn.1001-5256.2021.03.026
Abstract(1248) HTML (547) PDF (1838KB)(69)
Abstract:
Objective To investigate the features of liver injury and related influencing factors in adolescents and adults with infectious mononucleosis (IM). Methods A retrospective analysis was performed to investigate the features of liver injury in adolescents and adults with IM who were hospitalized in Pe...
Role and mechanism of hepatic stellate cells in the pathogenesis of mice with acute-on-chronic liver failure
Zhen TIAN, Lisha WANG, Naijuan YAO, Yingren ZHAO, Litao RUAN
2021, 37(3): 642-647. DOI: 10.3969/j.issn.1001-5256.2021.03.027
Abstract(1043) HTML (339) PDF (4302KB)(65)
Abstract:
Objective To investigate the role of hepatic stellate cell (HSC) inflammation in the pathogenesis of acute-on-chronic liver failure (ACLF). Methods A total of 45 male Kunming mice were randomly divided into control group, model group, and N-acetylcysteine (NAC) group. The mice in the model group and...
Original articles_Biliary diseases
Construction and verification of a new nomogram for predicting stone recurrence after endoscopic minimally invasive gallbladder-preserving cholecystolithotomy at high altitude
Xuepeng MEI, Xiaobin CHEN, Shizheng PI, Yichong CHEN, Junhua XING, Haijiu WANG, Shuai GAO, Ying ZHOU
2021, 37(3): 648-653. DOI: 10.3969/j.issn.1001-5256.2021.03.028
Abstract(586) HTML (212) PDF (2761KB)(37)
Abstract:
Objective To investigate related factors for stone recurrence after endoscopic minimally invasive gallbladder-preserving cholecystolithotomy, and to establish a nomogram model for predicting the risk of stone recurrence after surgery based on independent risk factors. Methods A retrospective analysi...
Original articles_Pancreatic diseases
Association of the duration of systemic inflammatory response syndrome with infectious pancreatic necrosis at the initial stage of acute pancreatitis
Yongfeng YAN, Xin JIANG, Rui ZHONG, Huan XU, Yan PENG, Xiaowei TANG
2021, 37(3): 654-659. DOI: 10.3969/j.issn.1001-5256.2021.03.029
Abstract(742) HTML (134) PDF (2124KB)(59)
Abstract:
Objective To investigate the potential association between early-stage inflammatory response and late-stage infectious pancreatic necrosis (IPN) in patients with acute pancreatitis (AP). Methods A retrospective analysis was performed for the clinical data of 219 patients with moderate-severe acute p...
Value of neutrophil-lymphocyte ratio combined with apolipoprotein A-I level in predicting the severity of acute pancreatitis in the early stage after admission
Jin XU, Yan PENG, Chuankang TANG
2021, 37(3): 660-665. DOI: 10.3969/j.issn.1001-5256.2021.03.030
Abstract(678) HTML (161) PDF (1991KB)(71)
Abstract:
Objective To investigate the value of neutrophil-lymphocyte ratio (NLR) combined with apolipoprotein A-I (ApoA-I) level in predicting the severity of acute pancreatitis (AP). Methods A retrospective analysis was performed for 460 patients with AP who were admitted to The Affiliated Hospital of South...
Original articles_Case reports
Multidisciplinary treatment of hepatocellular carcinoma with tumor thrombosis in the left portal vein: A case report
Jihong YANG, Guoxiang CHEN, Mo ZHOU, Jisen ZHAO, Yuan WANG, Yuanlong ZHOU
2021, 37(3): 666-679. DOI: 10.3969/j.issn.1001-5256.2021.03.031
Abstract(814) HTML (430) PDF (3239KB)(53)
Abstract:
Anti-PD-1 monoclonal antibody combined with apatinib in treatment of rare primary squamous cell carcinoma of the liver: A case report
Yuchen FEI, Donglai LYU
2021, 37(3): 670-672. DOI: 10.3969/j.issn.1001-5256.2021.03.032
Abstract(526) HTML (147) PDF (2972KB)(31)
Abstract:
A case of adult infectious mononucleosis with chickenpox
Yanan DONG, Yinhua ZHANG, Yahua GONG, Huiqin TENG, Wei LIU, Jianjie CHEN
2021, 37(3): 673-675. DOI: 10.3969/j.issn.1001-5256.2021.03.033
Abstract(758) HTML (146) PDF (1821KB)(32)
Abstract:
Primary biliary cholangitis with gastric diffuse large B-cell lymphoma: A case report
Lina FENG, Jianjie HUANG, Zhixin TU, Yan WANG, Xiaoxue ZHANG, Bo MA, Xiaoyu WEN, Qinglong JIN
2021, 37(3): 676-678. DOI: 10.3969/j.issn.1001-5256.2021.03.034
Abstract(523) HTML (155) PDF (2353KB)(33)
Abstract:
Severe hemolytic jaundice caused by glucose-6-phosphate dehydrogenase deficiency: A case report
Yipin LYU, Yong ZHANG, Shanhong TANG
2021, 37(3): 679-680. DOI: 10.3969/j.issn.1001-5256.2021.03.035
Abstract(651) HTML (207) PDF (1812KB)(38)
Abstract:
Reviews
Research advances in infection of renal tubular cells by hepatitis B virus
Yingjuan LI, Guohe FENG
2021, 37(3): 681-684. DOI: 10.3969/j.issn.1001-5256.2021.03.036
Abstract(526) HTML (131) PDF (1812KB)(64)
Abstract:
The kidney plays a key role in hepatitis B virus (HBV) infection of liver cells. The pathogenesis of HBV-associated glomerulonephritis (HBV-GN) remains unclear, and the mechanism of HBV directly causing the injury of renal tubules has been taken seriously in recent years. HBV can induce the apoptosi...
Adjuvant therapies after surgery for hepatocellular carcinoma with microvascular invasion
Tianle GONG, Ping YUE, Jun YAN, Xun LI
2021, 37(3): 685-688. DOI: 10.3969/j.issn.1001-5256.2021.03.037
Abstract(720) HTML (465) PDF (1853KB)(62)
Abstract:
The high recurrence rate of hepatocellular carcinoma (HCC) after surgery cannot be ignored, but there are still no consensus statements and guideline recommendations for adjuvant therapies after HCC surgery. Current studies have shown that microvascular invasion is one of the high-risk factors for p...
Research advances in hepatocellular carcinoma-related imbalance of bile acid metabolism and related regulatory mechanism
Zherui LIU, Xiaodong JIA, Yinying LU
2021, 37(3): 690-694. DOI: 10.3969/j.issn.1001-5256.2021.03.038
Abstract(1186) HTML (262) PDF (1817KB)(111)
Abstract:
Bile acid metabolism, gut microbiota, and bile acid receptors are involved in the development and progression of hepatocellular carcinoma (HCC). There are substantial increases in the levels of some bile acids, such as glycocholic acid, taurocholic acid, and taurochenodeoxycholic acid, in the liver ...
Role of circular RNA in the development and progression of hepatocellular carcinoma
Xin CAI, Juanjuan CHEN, Dongling TANG, Pingan ZHANG
2021, 37(3): 695-698. DOI: 10.3969/j.issn.1001-5256.2021.03.039
Abstract(923) HTML (211) PDF (1810KB)(42)
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the study on the regulatory mechanisms of the invasion and migration of HCC is of great significance to clinical diagnosis and treatment. Circular RNA (circRNA), as an important member of the non-coding RNA f...
Mechanism of action of non-coding RNA in sorafenib resistance in hepatocellular carcinoma
Guoxiang CHEN, Mo ZHOU, Sheng CHEN, Yuan WANG, Yuanlong ZHOU, Jihong YANG
2021, 37(3): 699-703. DOI: 10.3969/j.issn.1001-5256.2021.03.040
Abstract(1070) HTML (213) PDF (2217KB)(49)
Abstract:
Sorafenib, as the first-line treatment drug for advanced hepatocellular carcinoma (HCC), can effectively improve the prognosis of patients with HCC, but sorafenib resistance has become a major obstacle to the therapeutic outcome of HCC. Recent studies have shown that non-coding RNA plays a key role ...
Role of long non-coding RNA MALAT1 in the development and progression of hepatocellular carcinoma
Yongkang SUN, Xuebo YAN, Zemin ZHU, Dingcheng SHEN, Zhiqin XIE, Zhijian ZHAO, Caixi TANG
2021, 37(3): 704-708. DOI: 10.3969/j.issn.1001-5256.2021.03.041
Abstract(718) HTML (338) PDF (1820KB)(54)
Abstract:
Hepatocellular carcinoma (HCC) has the features of high incidence rate, low survival rate, poor treatment outcome, and complex pathogenesis. In recent years, many studies have shown that long non-coding RNA (lncRNA) MALAT1 is upregulated in HCC and can promote the proliferation, invasion, and metast...
Research advances in dietary intervention in the treatment of metabolic associated fatty liver disease
Junzhao YE, Yansong LIN, Bihui ZHONG
2021, 37(3): 709-713. DOI: 10.3969/j.issn.1001-5256.2021.03.042
Abstract(804) HTML (405) PDF (1816KB)(107)
Abstract:
Poor dietary habit is an important cause of the global prevalence of metabolic associated fatty liver disease (MAFLD), and the adjustment of dietary pattern is the cornerstone of MAFLD management. In recent years, a large number of new dietary intervention methods have been proposed and applied in t...
Role of HCO3- umbrella in the pathogenesis of primary biliary cholangitis
Yinghao CHANG, Dan JING, Wenjiao XU, Xiaolei ZHOU, Xiaoping WANG, Shanhong TANG
2021, 37(3): 714-717. DOI: 10.3969/j.issn.1001-5256.2021.03.043
Abstract(774) HTML (317) PDF (1807KB)(48)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune disease. Although PBC has the features of autoimmune disease, it has poor response to immunosuppressants and good response to the drugs participating in bile acid metabolism, such as ursodeoxycholic acid. Studies have shown that the bicarbonate secr...
Role of anion exchanger 2 in the pathogenesis of primary biliary cholangitis
Xi CHU, Lianjun XING
2021, 37(3): 718-720. DOI: 10.3969/j.issn.1001-5256.2021.03.044
Abstract(582) HTML (106) PDF (1952KB)(32)
Abstract:
The etiology and pathogenesis of primary biliary cholangitis (PBC) remain unclear at present, and it is believed that the change in bile duct microenvironment and autoimmune response are the main factors for the onset of this disease. Anion exchanger 2 (AE2) is an HCO3-/Cl- exchange protein located ...
Effect of statins on the progression and prognosis of chronic liver diseases
Shuai WANG, Yonggui ZHANG, Jiangbin WANG, Yan XU
2021, 37(3): 721-724. DOI: 10.3969/j.issn.1001-5256.2021.03.045
Abstract(659) HTML (350) PDF (1803KB)(77)
Abstract:
Chronic liver diseases can progress to liver fibrosis and cirrhosis and may lead to portal hypertension and even hepatocellular carcinoma. In recent years, more and more studies have shown that statins can improve liver histology, delay progression to liver fibrosis, and reduce the risk of decompens...
Role of microRNA-125b in the development and progression of various chronic liver diseases
Nengyuan LU, Jiahui WANG, Fangfei ZHONG, Lei WANG, Yue PENG, Tiejian ZHAO, Yang ZHENG
2021, 37(3): 725-728. DOI: 10.3969/j.issn.1001-5256.2021.03.046
Abstract(719) HTML (153) PDF (1811KB)(34)
Abstract:
MicroRNA (miRNA) is a type of small non-coding RNA and acts as a post-transcriptional regulator of gene expression. This article briefly describes the etiology of various chronic liver diseases, including metabolic dysfunction-associated fatty liver disease, chronic hepatitis B, chronic hepatitis C,...
Association between nonalcoholic fatty liver disease and acute pancreatitis
Tingting WANG, Jiajun HE, Chuting YANG, Yuanhao LI, Weiwei CHEN, Jun LIU
2021, 37(3): 729-732. DOI: 10.3969/j.issn.1001-5256.2021.03.047
Abstract(915) HTML (143) PDF (1806KB)(59)
Abstract:
Acute pancreatitis (AP) is a common acute abdominal disease in clinical practice. As the hepatic manifestation of metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) is closely associated with the severity and prognosis of AP. This article elaborates on the mechanism of action of NAFLD in t...
Advances in radiotherapy for pancreatic cancer from 2019 to 2020
Gang REN, Yingjie WANG
2021, 37(3): 733-736. DOI: 10.3969/j.issn.1001-5256.2021.03.048
Abstract(1166) HTML (603) PDF (1806KB)(118)
Abstract:
With the rapid development of radiotherapy equipment, imaging technology, and artificial intelligence, radiotherapy has entered the era of precision therapy. Radiotherapy is one of the important methods for the treatment of pancreatic cancer, and rapid progress has been made in related concepts and ...
    

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