Role of circular RNA in the development and progression of hepatocellular carcinoma

Xin CAI; Juanjuan CHEN; Dongling TANG; Pingan ZHANG

doi:10.3969/j.issn.1001-5256.2021.03.039

Volume 37 Issue 3

Mar. 2021

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2021 > 37(3): 695-698

PDF( 1810 KB)

Role of circular RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.03.039

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China

Received Date: 2020-08-14
Accepted Date: 2020-09-14
Published Date: 2021-03-20

Abstract

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the study on the regulatory mechanisms of the invasion and migration of HCC is of great significance to clinical diagnosis and treatment. Circular RNA (circRNA), as an important member of the non-coding RNA family, plays the role of microRNA (miRNA) sponge in hepatocytes due to its highly stable circular structure. It also plays an important role in HCC progression by regulating miRNA or promoting the expression of target genes through the competitive endogenous RNA mechanism. This article explores the mechanism of action of circRNA in the pathogenesis of HCC, so as to help with the screening for diagnostic markers of HCC and the development of effective therapeutic targets for HCC.
- Carcinoma, Hepatocellular,
- CircRNA,
- Diagnosis,
- Therapeutics

FullText(HTML)

References(42)

References

[1]	Bureau of Medical Administration, National Health Commission of the People's Republic of China. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)[J]. J Clin Hepatol, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007 中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗规范(2019年版)[J]. 临床肝胆病杂志, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007
[2]	HSU MT, COCA-PRADOS M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells[J]. Nature, 1979, 280(5720): 339-340. DOI: 10.1038/280339a0
[3]	ASHWAL-FLUSS R, MEYER M, PAMUDURTI NR, et al. circRNA biogenesis competes with pre-mRNA splicing[J]. Mol Cell, 2014, 56(1): 55-66. DOI: 10.1016/j.molcel.2014.08.019
[4]	QU S, YANG X, LI X, et al. Circular RNA: A new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-148. DOI: 10.1016/j.canlet.2015.06.003
[5]	JECK WR, SORRENTINO JA, WANG K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats[J]. RNA, 2013, 19(2): 141-157. DOI: 10.1261/rna.035667.112
[6]	CHEN G, SHI Y, LIU M, et al. circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma[J]. Cell Death Dis, 2018, 9(2): 175. DOI: 10.1038/s41419-017-0204-3
[7]	WU M, DENG X, ZHONG Y, et al. MafF is regulated via the circ-ITCH/miR-224-5p axis and acts as a tumor suppressor in hepatocellular carcinoma[J]. Oncol Res, 2020, 28(3): 299-309. DOI: 10.3727/096504020X15796890809840
[8]	O'GORMAN W, KWEK KY, THOMAS B, et al. Non-coding RNA in transcription initiation[J]. Biochem Soc Symp, 2006, 73: 131-140. DOI: 10.1042/bss0730131
[9]	LI Z, HUANG C, BAO C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. DOI: 10.1038/nsmb.2959
[10]	WANG Y, WANG Z. Efficient backsplicing produces translatable circular mRNAs[J]. RNA, 2015, 21(2): 172-179. DOI: 10.1261/rna.048272.114
[11]	CHEN W, WU XH, SUN SG. CircRNA related databases and its application[J]. Chin J Biochem Mol Biol, 2019, 35(1): 35-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SWHZ201901007.htm 陈伟, 吴仙华, 孙绍光. circRNA相关数据库及其应用[J]. 中国生物化学与分子生物学报, 2019, 35(1): 35-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SWHZ201901007.htm
[12]	PANDEY PR, MUNK R, KUNDU G, et al. Methods for analysis of circular RNAs[J]. Wiley Interdiscip Rev RNA, 2020, 11(1): e1566.
[13]	CHENG Q, NING D, CHEN J, et al. SIX1 and DACH1 influence the proliferation and apoptosis of hepatocellular carcinoma through regulating p53[J]. Cancer Biol Ther, 2018, 19(5): 381-390. DOI: 10.1080/15384047.2018.1423920
[14]	FU L, CHEN Q, YAO T, et al. Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma[J]. Oncotarget, 2017, 8(27): 43878-43888. DOI: 10.18632/oncotarget.16709
[15]	LI MF, LI YH, HE YH, et al. Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC[J]. Biomed Pharmacother, 2018, 99: 848-858. DOI: 10.1016/j.biopha.2018.01.150
[16]	CHEN KH, PAN JF, CHEN ZX, et al. Effects of hsa_circ_0000711 expression level on proliferation and apoptosis of hepatoma cells[J]. Eur Rev Med Pharmacol Sci, 2020, 24(8): 4161-4171.
[17]	FU L, JIANG Z, LI T, et al. Circular RNAs in hepatocellular carcinoma: Functions and implications[J]. Cancer Med, 2018, 7(7): 3101-3109. DOI: 10.1002/cam4.1574
[18]	ZHANG X, XU Y, QIAN Z, et al. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma[J]. Cell Death Dis, 2018, 9(11): 1091. DOI: 10.1038/s41419-018-1132-6
[19]	CHEN D, ZHANG C, LIN J, et al. Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma[J]. Cancer Manag Res, 2018, 10: 1275-1283. DOI: 10.2147/CMAR.S166740
[20]	GUAN Z, TAN J, GAO W, et al. Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR-486/CDK4 pathway[J]. J Cell Physiol, 2018, 234(1): 500-508.
[21]	YU J, XU QG, WANG ZG, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma[J]. J Hepatol, 2018, 68(6): 1214-1227. DOI: 10.1016/j.jhep.2018.01.012
[22]	QIN M, LIU G, HUO X, et al. Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma[J]. Cancer Biomark, 2016, 16(1): 161-169. DOI: 10.3233/CBM-150552
[23]	SONG C, LI D, LIU H, et al. The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1[J]. J Cell Physiol, 2019, 234(3): 2460-2470. DOI: 10.1002/jcp.26764
[24]	TANG L, QIU LD, QIN W, et al. Expression of circular RNA FLI1 in patients with hepatocellular carcinoma and its association with prognosis[J]. J Clin Hepatol, 2019, 35(9): 1980-1984. DOI: 10.3969/j.issn.1001-5256.2019.09.019 唐凌, 邱露蝶, 秦文, 等. 环状RNA FLI1在肝细胞癌患者中的表达及其与预后的关系[J]. 临床肝胆病杂志, 2019, 35(9): 1980-1984. DOI: 10.3969/j.issn.1001-5256.2019.09.019
[25]	HAN D, LI J, WANG H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J]. Hepatology, 2017, 66(4): 1151-1164. DOI: 10.1002/hep.29270
[26]	WANG L, LONG H, ZHENG Q, et al. Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression[J]. Mol Cancer, 2019, 18(1): 119. DOI: 10.1186/s12943-019-1046-7
[27]	ZHANG PF, WEI CY, HUANG XY, et al. Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression[J]. Mol Cancer, 2019, 18(1): 105. DOI: 10.1186/s12943-019-1031-1
[28]	HU ZQ, ZHOU SL, LI J, et al. Circular RNA sequencing identifies circASAP1 as a key regulator in hepatocellular carcinoma metastasis[J]. Hepatology, 2020, 72(3): 906-922. DOI: 10.1002/hep.31068
[29]	LI Q, PAN X, ZHU D, et al. Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR-338-3p/PKM2 axis under hypoxic stress[J]. Hepatology, 2019, 70(4): 1298-1316. DOI: 10.1002/hep.30671
[30]	WANG YG, WANG T, DING M, et al. hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307[J]. Cancer Lett, 2019, 460: 128-138. DOI: 10.1016/j.canlet.2019.06.007
[31]	WEI Y, CHEN X, LIANG C, et al. A noncoding regulatory RNAs network driven by circ-CDYL acts specifically in the early stages hepatocellular carcinoma[J]. Hepatology, 2020, 71(1): 130-147. DOI: 10.1002/hep.30795
[32]	CAO Y, TAO Q, KAO X, et al. Hsa-circRNA-103809 promotes hepatocellular carcinoma development via microRNA-1270/PLAG1 like zinc finger 2 axis[J]. Dig Dis Sci, 2020. [Online ahead of print]
[33]	JIANG QL, FENG SJ, YANG ZY, et al. CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism[J]. Chin Med J (Engl), 2020, 133(15): 1774-1785. DOI: 10.1097/CM9.0000000000000917
[34]	LIU W, YIN C, LIU Y. Circular RNA circ_0091579 promotes hepatocellular carcinoma proliferation, migration, invasion, and glycolysis through miR-490-5p/CASC3 axis[J]. Cancer Biother Radiopharm, 2020. [Online ahead of print]
[35]	LIU X, YANG L, JIANG D, et al. Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway[J]. Cancer Cell Int, 2020, 20: 295. DOI: 10.1186/s12935-020-01346-0
[36]	JIA C, YAO Z, LIN Z, et al. circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression[J]. J Cell Physiol, 2021, 236(2): 1252-1269. DOI: 10.1002/jcp.29931
[37]	WANG M, YANG Y, YANG J, et al. circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1[J]. Life Sci, 2020, 257: 118082. DOI: 10.1016/j.lfs.2020.118082
[38]	ZHANG W, ZHU L, YANG G, et al. Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p[J]. Biosci Rep, 2020, 40(7): BSR20191418. DOI: 10.1042/BSR20191418
[39]	CHEN W, QUAN Y, FAN S, et al. Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression[J]. Cancer Lett, 2020, 475: 119-128. DOI: 10.1016/j.canlet.2020.01.022
[40]	XIONG DD, FENG ZB, LAI ZF, et al. High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma[J]. Cell Death Dis, 2019, 10(9): 658. DOI: 10.1038/s41419-019-1890-9
[41]	CHEN L, KONG R, WU C, et al. Circ-MALAT1 functions as both an mRNA translation brake and a microRNA sponge to promote self-renewal of hepatocellular cancer stem cells[J]. Adv Sci (Weinh), 2020, 7(4): 1900949. DOI: 10.1002/advs.201900949
[42]	HUANG XY, ZHANG PF, WEI CY, et al. Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis[J]. Mol Cancer, 2020, 19(1): 92. DOI: 10.1186/s12943-020-01213-6

Relative Articles

[1]	Zhao ZHOU, Abulaiti ABUDUREXITI, Zhiqiang GU, Jing CHANG, Xin LIU, Fengmin LU. Early initiation of antiviral therapy reduces the risk of hepatocellular carcinoma in individuals with chronic hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2023, 39(1): 31-36. doi: 10.3969/j.issn.1001-5256.2023.01.005
[2]	Yi LE, Hao YANG, Hu LIU, Zhaoyang CUI, Xiangning ZHAO, Liang AN, Haizhu LI, Shaogeng ZHANG. Advances in the diagnosis and treatment of gallbladder carcinoma[J]. Journal of Clinical Hepatology, 2023, 39(11): 2738-2744. doi: 10.3969/j.issn.1001-5256.2023.11.032
[3]	Shuying MIAO, Jun YANG, Wenyan GUAN, Biao ZHANG, Lu HE, Zhiwen FAN. Role of circular RNA in the development, progression, diagnosis, and treatment of hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2023, 39(8): 1983-1991. doi: 10.3969/j.issn.1001-5256.2023.08.033
[4]	Xiaomei QIN, Shuangjie LI. Etiology, diagnosis, and treatment of acute liver failure in neonates[J]. Journal of Clinical Hepatology, 2022, 38(2): 260-263. doi: 10.3969/j.issn.1001-5256.2022.02.002
[5]	Xue WU, Weike CHU, Hui ZHOU, Bin NIU, Peng ZHANG, Jing FENG, Yuqiang MI, Ping LI. Value of external validation of REAL-B score in predicting the risk of hepatocellular carcinoma in chronic hepatitis B patients treated by antiviral therapy[J]. Journal of Clinical Hepatology, 2022, 38(8): 1768-1773. doi: 10.3969/j.issn.1001-5256.2022.08.010
[6]	Kailing XIE, Feng XU. Mechanism of action of Huaier granules in treatment of hepatocellular carcinoma and advances in its clinical application[J]. Journal of Clinical Hepatology, 2022, 38(3): 676-681. doi: 10.3969/j.issn.1001-5256.2022.03.038
[7]	Huijuan FENG, Yu ZHANG, Chuanshang ZHUO, Chenjun HUANG, Meng FANG, Lijuan LIU. Value of multi-glycan in the auxiliary diagnosis of dual-phenotype hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2022, 38(6): 1317-1322. doi: 10.3969/j.issn.1001-5256.2022.06.019
[8]	Yu WANG, Min WANG, Guanhua ZHANG, Fuliang HE, Xiaojuan OU, Jidong JIA. Clinical diagnosis, staging, and therapeutic principles of liver cirrhosis[J]. Journal of Clinical Hepatology, 2021, 37(1): 17-21. doi: 10.3969/j.issn.1001-5256.2021.01.004
[9]	Radiology of Infection Sub-branch, Radiology Branch, Chinese Medical Association, Committee on Radiology of Infection, Radiology Branch, Chinese Medical Doctor Association, Radiology Committee on Infectious and Inflammatory Disease, Chinese Research Hospital Association, Radiology of Infection Branch, Working and Treating Committee of HIV/AIDS and STD Association, Radiology of Infectious Disease Management Sub-branch, Infectious Disease Management Branch, Hospital Management Association in China, Beijing Imaging Diagnosis and Treatment Technology Innovation Alliance. Consensus on imaging techniques and diagnostic criteria for hepatitis B virus related early hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(4): 787-791. doi: 10.3969/j.issn.1001-5256.2021.04.013
[10]	Fengming YI, Longxiang XIN, Long FENG. Screening of differentially expressed circular RNAs in intrahepatic cholangiocarcinoma based on microarray technique and potential mechanism of circRNA_000585[J]. Journal of Clinical Hepatology, 2021, 37(10): 2343-2347. doi: 10.3969/j.issn.1001-5256.2021.10.017
[11]	Guoxiang CHEN, Mo ZHOU, Sheng CHEN, Yuan WANG, Yuanlong ZHOU, Jihong YANG. Mechanism of action of non-coding RNA in sorafenib resistance in hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(3): 699-703. doi: 10.3969/j.issn.1001-5256.2021.03.040
[12]	Huijun XIE, Nasot Rashed, Yong NING, Chuan GAO. Current status of research on circulating microRNAs as diagnostic markers for hepatocellular carcinoma[J]. Journal of Clinical Hepatology, 2021, 37(2): 448-451. doi: 10.3969/j.issn.1001-5256.2021.02.042
[13]	Weikai YU, Tingting FENG, Xiaobing CHEN, Jiye LUO, Wanwen FENG, Yanli WANG. Effect of circRNA hsa_circ_0091579 on the proliferation, migration, and invasion of hepatoma cells[J]. Journal of Clinical Hepatology, 2021, 37(5): 1126-1131. doi: 10.3969/j.issn.1001-5256.2021.05.029
[14]	Shiyan YAN, Jiangao FAN. Diagnosis and treatment of hepatocellular carcinoma associated with nonalcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2021, 37(8): 1748-1752. doi: 10.3969/j.issn.1001-5256.2021.08.002
[15]	Shengnan DU, Jingjing GAO, Tao WANG, Yuanye JIANG, Qin CAO. Value of circular RNA in the diagnosis and treatment of nonalcoholic fatty liver disease[J]. Journal of Clinical Hepatology, 2021, 37(11): 2684-2688. doi: 10.3969/j.issn.1001-5256.2021.11.043
[16]	Zhu HongMei, Wang QinYing. Advances in the diagnosis and treatment of nonalcoholic fatty liver disease-related liver fibrosis[J]. Journal of Clinical Hepatology, 2020, 36(1): 178-181. doi: 10.3969/j.issn.1001-5256.2020.01.042
[17]	YANG Xu, SUN WenBing, GAO Jun. Diagnosis and treatment of hepatic vascular tumors[J]. Journal of Clinical Hepatology, 2020, 36(11): 2569-2573. doi: 10.3969/j.issn.1001-5256.2020.11.039
[18]	Xu XiaoLei, Gao CanCan, Wang ZhiXin, Wang Zhan, ZHOU Ying, Wang HaiJiu, Ye HaiWen, Pang MingQuan, Zhou Hu, Hou YaJun, Guo Bing, Fan HaiNing. Advances in the diagnosis and treatment of cystic space-occupying lesions in the liver[J]. Journal of Clinical Hepatology, 2019, 35(5): 1118-1122. doi: 10.3969/j.issn.1001-5256.2019.05.043
[19]	Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association. Consensus on the diagnosis and therapy of hepatic fibrosis(2019)[J]. Journal of Clinical Hepatology, 2019, 35(10): 2163-2172. doi: 10.3969/j.issn.1001-5256.2019.10.007
[20]	Tang Ling, Qiu LuDie, Qin Wen, Wu Gang. Expression of circular RNA FLI1 in patients with hepatocellular carcinoma and its association with prognosis[J]. Journal of Clinical Hepatology, 2019, 35(9): 1980-1984. doi: 10.3969/j.issn.1001-5256.2019.09.019

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	符仲标，陈琼，王勇，刘昌江，唐明亮，吴智明. 环状RNA TADA2A在肝癌组织中的表达及其对肝癌细胞凋亡的影响. 中西医结合肝病杂志. 2022(11): 992-994 .
2.	刘洁兰，李钰颖，卢诗丽，侯沅林，胡婷，唐玉莲. 基于生物信息学分析NAA15在肝脏肝细胞癌中的表达及其预后价值. 中国医药科学. 2022(23): 153-156+177 .

Other cited types(2)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(1)

Get Citation

PDF

XML

Article Metrics

Article views (911) PDF downloads(41)

Role of circular RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.03.039