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Volume 37 Issue 3
Mar.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(3): 695-698

Role of circular RNA in the development and progression of hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2021.03.039

  • Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China

  • Received Date: 2020-08-14
  • Accepted Date: 2020-09-14
  • Published Date: 2021-03-20
    Abstract
  • Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the study on the regulatory mechanisms of the invasion and migration of HCC is of great significance to clinical diagnosis and treatment. Circular RNA (circRNA), as an important member of the non-coding RNA family, plays the role of microRNA (miRNA) sponge in hepatocytes due to its highly stable circular structure. It also plays an important role in HCC progression by regulating miRNA or promoting the expression of target genes through the competitive endogenous RNA mechanism. This article explores the mechanism of action of circRNA in the pathogenesis of HCC, so as to help with the screening for diagnostic markers of HCC and the development of effective therapeutic targets for HCC.

     

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    • References(42)
  • [1]
    Bureau of Medical Administration, National Health Commission of the People's Republic of China. Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)[J]. J Clin Hepatol, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007

    中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗规范(2019年版)[J]. 临床肝胆病杂志, 2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007
    [2]
    HSU MT, COCA-PRADOS M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells[J]. Nature, 1979, 280(5720): 339-340. DOI: 10.1038/280339a0
    [3]
    ASHWAL-FLUSS R, MEYER M, PAMUDURTI NR, et al. circRNA biogenesis competes with pre-mRNA splicing[J]. Mol Cell, 2014, 56(1): 55-66. DOI: 10.1016/j.molcel.2014.08.019
    [4]
    QU S, YANG X, LI X, et al. Circular RNA: A new star of noncoding RNAs[J]. Cancer Lett, 2015, 365(2): 141-148. DOI: 10.1016/j.canlet.2015.06.003
    [5]
    JECK WR, SORRENTINO JA, WANG K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats[J]. RNA, 2013, 19(2): 141-157. DOI: 10.1261/rna.035667.112
    [6]
    CHEN G, SHI Y, LIU M, et al. circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma[J]. Cell Death Dis, 2018, 9(2): 175. DOI: 10.1038/s41419-017-0204-3
    [7]
    WU M, DENG X, ZHONG Y, et al. MafF is regulated via the circ-ITCH/miR-224-5p axis and acts as a tumor suppressor in hepatocellular carcinoma[J]. Oncol Res, 2020, 28(3): 299-309. DOI: 10.3727/096504020X15796890809840
    [8]
    O'GORMAN W, KWEK KY, THOMAS B, et al. Non-coding RNA in transcription initiation[J]. Biochem Soc Symp, 2006, 73: 131-140. DOI: 10.1042/bss0730131
    [9]
    LI Z, HUANG C, BAO C, et al. Exon-intron circular RNAs regulate transcription in the nucleus[J]. Nat Struct Mol Biol, 2015, 22(3): 256-264. DOI: 10.1038/nsmb.2959
    [10]
    WANG Y, WANG Z. Efficient backsplicing produces translatable circular mRNAs[J]. RNA, 2015, 21(2): 172-179. DOI: 10.1261/rna.048272.114
    [11]
    CHEN W, WU XH, SUN SG. CircRNA related databases and its application[J]. Chin J Biochem Mol Biol, 2019, 35(1): 35-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SWHZ201901007.htm

    陈伟, 吴仙华, 孙绍光. circRNA相关数据库及其应用[J]. 中国生物化学与分子生物学报, 2019, 35(1): 35-41. https://www.cnki.com.cn/Article/CJFDTOTAL-SWHZ201901007.htm
    [12]
    PANDEY PR, MUNK R, KUNDU G, et al. Methods for analysis of circular RNAs[J]. Wiley Interdiscip Rev RNA, 2020, 11(1): e1566.
    [13]
    CHENG Q, NING D, CHEN J, et al. SIX1 and DACH1 influence the proliferation and apoptosis of hepatocellular carcinoma through regulating p53[J]. Cancer Biol Ther, 2018, 19(5): 381-390. DOI: 10.1080/15384047.2018.1423920
    [14]
    FU L, CHEN Q, YAO T, et al. Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma[J]. Oncotarget, 2017, 8(27): 43878-43888. DOI: 10.18632/oncotarget.16709
    [15]
    LI MF, LI YH, HE YH, et al. Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC[J]. Biomed Pharmacother, 2018, 99: 848-858. DOI: 10.1016/j.biopha.2018.01.150
    [16]
    CHEN KH, PAN JF, CHEN ZX, et al. Effects of hsa_circ_0000711 expression level on proliferation and apoptosis of hepatoma cells[J]. Eur Rev Med Pharmacol Sci, 2020, 24(8): 4161-4171.
    [17]
    FU L, JIANG Z, LI T, et al. Circular RNAs in hepatocellular carcinoma: Functions and implications[J]. Cancer Med, 2018, 7(7): 3101-3109. DOI: 10.1002/cam4.1574
    [18]
    ZHANG X, XU Y, QIAN Z, et al. circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma[J]. Cell Death Dis, 2018, 9(11): 1091. DOI: 10.1038/s41419-018-1132-6
    [19]
    CHEN D, ZHANG C, LIN J, et al. Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma[J]. Cancer Manag Res, 2018, 10: 1275-1283. DOI: 10.2147/CMAR.S166740
    [20]
    GUAN Z, TAN J, GAO W, et al. Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR-486/CDK4 pathway[J]. J Cell Physiol, 2018, 234(1): 500-508.
    [21]
    YU J, XU QG, WANG ZG, et al. Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma[J]. J Hepatol, 2018, 68(6): 1214-1227. DOI: 10.1016/j.jhep.2018.01.012
    [22]
    QIN M, LIU G, HUO X, et al. Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma[J]. Cancer Biomark, 2016, 16(1): 161-169. DOI: 10.3233/CBM-150552
    [23]
    SONG C, LI D, LIU H, et al. The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1[J]. J Cell Physiol, 2019, 234(3): 2460-2470. DOI: 10.1002/jcp.26764
    [24]
    TANG L, QIU LD, QIN W, et al. Expression of circular RNA FLI1 in patients with hepatocellular carcinoma and its association with prognosis[J]. J Clin Hepatol, 2019, 35(9): 1980-1984. DOI: 10.3969/j.issn.1001-5256.2019.09.019

    唐凌, 邱露蝶, 秦文, 等. 环状RNA FLI1在肝细胞癌患者中的表达及其与预后的关系[J]. 临床肝胆病杂志, 2019, 35(9): 1980-1984. DOI: 10.3969/j.issn.1001-5256.2019.09.019
    [25]
    HAN D, LI J, WANG H, et al. Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression[J]. Hepatology, 2017, 66(4): 1151-1164. DOI: 10.1002/hep.29270
    [26]
    WANG L, LONG H, ZHENG Q, et al. Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression[J]. Mol Cancer, 2019, 18(1): 119. DOI: 10.1186/s12943-019-1046-7
    [27]
    ZHANG PF, WEI CY, HUANG XY, et al. Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression[J]. Mol Cancer, 2019, 18(1): 105. DOI: 10.1186/s12943-019-1031-1
    [28]
    HU ZQ, ZHOU SL, LI J, et al. Circular RNA sequencing identifies circASAP1 as a key regulator in hepatocellular carcinoma metastasis[J]. Hepatology, 2020, 72(3): 906-922. DOI: 10.1002/hep.31068
    [29]
    LI Q, PAN X, ZHU D, et al. Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR-338-3p/PKM2 axis under hypoxic stress[J]. Hepatology, 2019, 70(4): 1298-1316. DOI: 10.1002/hep.30671
    [30]
    WANG YG, WANG T, DING M, et al. hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307[J]. Cancer Lett, 2019, 460: 128-138. DOI: 10.1016/j.canlet.2019.06.007
    [31]
    WEI Y, CHEN X, LIANG C, et al. A noncoding regulatory RNAs network driven by circ-CDYL acts specifically in the early stages hepatocellular carcinoma[J]. Hepatology, 2020, 71(1): 130-147. DOI: 10.1002/hep.30795
    [32]
    CAO Y, TAO Q, KAO X, et al. Hsa-circRNA-103809 promotes hepatocellular carcinoma development via microRNA-1270/PLAG1 like zinc finger 2 axis[J]. Dig Dis Sci, 2020. [Online ahead of print]
    [33]
    JIANG QL, FENG SJ, YANG ZY, et al. CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism[J]. Chin Med J (Engl), 2020, 133(15): 1774-1785. DOI: 10.1097/CM9.0000000000000917
    [34]
    LIU W, YIN C, LIU Y. Circular RNA circ_0091579 promotes hepatocellular carcinoma proliferation, migration, invasion, and glycolysis through miR-490-5p/CASC3 axis[J]. Cancer Biother Radiopharm, 2020. [Online ahead of print]
    [35]
    LIU X, YANG L, JIANG D, et al. Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway[J]. Cancer Cell Int, 2020, 20: 295. DOI: 10.1186/s12935-020-01346-0
    [36]
    JIA C, YAO Z, LIN Z, et al. circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression[J]. J Cell Physiol, 2021, 236(2): 1252-1269. DOI: 10.1002/jcp.29931
    [37]
    WANG M, YANG Y, YANG J, et al. circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1[J]. Life Sci, 2020, 257: 118082. DOI: 10.1016/j.lfs.2020.118082
    [38]
    ZHANG W, ZHU L, YANG G, et al. Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p[J]. Biosci Rep, 2020, 40(7): BSR20191418. DOI: 10.1042/BSR20191418
    [39]
    CHEN W, QUAN Y, FAN S, et al. Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression[J]. Cancer Lett, 2020, 475: 119-128. DOI: 10.1016/j.canlet.2020.01.022
    [40]
    XIONG DD, FENG ZB, LAI ZF, et al. High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma[J]. Cell Death Dis, 2019, 10(9): 658. DOI: 10.1038/s41419-019-1890-9
    [41]
    CHEN L, KONG R, WU C, et al. Circ-MALAT1 functions as both an mRNA translation brake and a microRNA sponge to promote self-renewal of hepatocellular cancer stem cells[J]. Adv Sci (Weinh), 2020, 7(4): 1900949. DOI: 10.1002/advs.201900949
    [42]
    HUANG XY, ZHANG PF, WEI CY, et al. Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis[J]. Mol Cancer, 2020, 19(1): 92. DOI: 10.1186/s12943-020-01213-6
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