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ISSN 2097-3497 (Online)
CN 22-1108/R
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2021 No.5
Theme Issue: Advances in research & development and clinical studies of novel anti-HBV drugs
Executive Chief Editor: Zhang Xiaodong 
College of Life Sciences, Nankai University
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Editorial
Perspectives in the development of new drugs against hepatitis B virus
Xiaodong ZHANG, Lina ZHAO
2021, 37(5): 993-998. DOI: 10.3969/j.issn.1001-5256.2021.05.001
Abstract(1378) HTML (329) PDF (2445KB)(241) Cited By (4)
Abstract:
Hepatitis B is a chronic infectious disease caused by hepatitis B virus (HBV) infection, with liver inflammatory lesions as the main clinical manifestation, and continuous replication of HBV can lead to abnormal liver function, liver cirrhosis, and even liver cancer. At present, a variety of anti-HB...
Discussions by experts
Research advances in animal models of hepatitis B virus infection
Weifeng YANG, Zhenchuan MIAO, Xijun SONG, Ming YIN
2021, 37(5): 999-1005. DOI: 10.3969/j.issn.1001-5256.2021.05.002
Abstract(1109) HTML (2314) PDF (1968KB)(361) Cited By (7)
Abstract:
For the ideal preclinical animal model of hepatitis B virus (HBV), its hepatocytes should allow HBV entry and cccDNA generation and have both innate and adaptive immune systems. However, HBV only naturally infects humans and chimpanzees due to highly restricted species specificity, and no effective ...
Clinical studies of new antiviral drugs for chronic hepatitis B
Hong ZHANG, Xiaoxue ZHU, Jiajia MAI, Hong CHEN, Jing ZHOU, Yue HU, Jia XU, Yanhua DING
2021, 37(5): 1006-1010. DOI: 10.3969/j.issn.1001-5256.2021.05.003
Abstract(999) HTML (526) PDF (2154KB)(163) Cited By (3)
Abstract:
Hepatitis B virus (HBV) infection is a major global public health issue. Clinical cure (also known as functional cure) of chronic hepatitis B (CHB) is the ideal therapeutic goal recommended by the latest guidelines for the prevention and treatment of CHB in China and globally. Optimized treatment re...
Current status of the treatment of chronic hepatitis B
Xuefu CHEN, Dongjing ZHANG, Xiaodan LUO, Ren CHEN
2021, 37(5): 1011-1015. DOI: 10.3969/j.issn.1001-5256.2021.05.004
Abstract(1581) HTML (294) PDF (1882KB)(289) Cited By (27)
Abstract:
Chronic hepatitis B caused by hepatitis B virus (HBV) infection is a global public health issue. Antiviral therapy for chronic HBV infection plays a critical role, and the goal of antiviral therapy is mainly defined by virological, serological, and biochemical parameters. As the two types of antivir...
Strategies and advances in targeting adaptive immunity to cure chronic hepatitis B
Wei ZHU, Xiaoyong ZHANG, Daqian ZHANG, Jinlin HOU
2021, 37(5): 1016-1021. DOI: 10.3969/j.issn.1001-5256.2021.05.005
Abstract(721) HTML (177) PDF (1997KB)(138) Cited By (2)
Abstract:
Chronic hepatitis B (CHB) is a major global public health issue, and although direct-acting antiviral agents can control hepatitis B virus (HBV) replication, it is difficult to achieve the cure of CHB. Host adaptive immune response plays a key role in eliminating HBV, and it is expected to achieve t...
Academic contention
Patients in the immune-tolerant phase of chronic HBV infection should be precisely treated with antiviral therapy
Tingting LI, Yanfang JIANG
2021, 37(5): 1022-1023. DOI: 10.3969/j.issn.1001-5256.2021.05.006
Abstract(469) HTML (102) PDF (1839KB)(101) Cited By (2)
Abstract:
Antiviral therapy for patients in the immune-tolerant phase of chronic HBV infection is beneficial for preventing liver cirrhosis and hepatocellular carcinoma
Hongyu JIA, Kezhou LIU
2021, 37(5): 1024-1025. DOI: 10.3969/j.issn.1001-5256.2021.05.007
Abstract(439) HTML (131) PDF (1891KB)(84) Cited By (5)
Abstract:
Patients in the immune-tolerant phase of chronic HBV infection should be actively treated with antiviral therapy
Yuan HUANG
2021, 37(5): 1026-1026. DOI: 10.3969/j.issn.1001-5256.2021.05.008
Abstract(459) HTML (87) PDF (1825KB)(80)
Abstract:
Dynamic measurement of spleen size and liver stiffness helps to judge whether antiviral therapy is needed in the immune-tolerant phase of HBV infection
Fengxia SUN
2021, 37(5): 1027-1027. DOI: 10.3969/j.issn.1001-5256.2021.05.009
Abstract(426) HTML (108) PDF (1828KB)(61)
Abstract:
The concept of individualized reference values of aminotransferases should be considered in treatment of chronic hepatitis B
Chunxi WANG
2021, 37(5): 1028-1028. DOI: 10.3969/j.issn.1001-5256.2021.05.010
Abstract(470) HTML (173) PDF (1827KB)(67) Cited By (3)
Abstract:
Guidelines
Chinese radiotherapy guidelines for primary hepatocellular carcinoma (2020 edition)
Chinese Association for Therapeutic Radiation Oncologists, Chinese Society for Therapeutic Radiology and Oncology, Chinese Medical Association, Committee of Radiation Oncology, Chinese Anti-Cancer Association
2021, 37(5): 1029-1033. DOI: 10.3760/cma.j.cn371439-20201208-00001
Abstract(926) HTML (1012) PDF (1638KB)(517) Cited By (26)
Abstract:
Expert consensus on emergency diagnosis and treatment of acute pancreatitis
Chinese Society for Emergency Medicine, Beijing-Tianjin-Hebei Alliance of Emergency Treatment and First Aid, Emergency Medicine Branch, Beijing Medical Association, Emergency Physicians Branch, Beijing Medical Doctor Association, Emergency Treatment and First Aid Branch, China Health Culture Association
2021, 37(5): 1034-1041. DOI: 10.3969/j.issn.1001-5256.2021.05.012
Abstract(1236) HTML (1455) PDF (1956KB)(1055) Cited By (128)
Abstract:
An excerpt of vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 practice guidance by the American Association for the Study of Liver Diseases
Wentao XU, Yue YIN, Yiling LI, Xingshun QI
2021, 37(5): 1042-1044. DOI: 10.3969/j.issn.1001-5256.2021.05.013
Abstract(653) HTML (132) PDF (1842KB)(99) Cited By (3)
Abstract:
An excerpt of AASLD expert panel consensus statement: Vaccines to prevent COVID-19 infection in patients with liver disease
Lianhui ZHAO, Jidong JIA
2021, 37(5): 1045-1046. DOI: 10.3969/j.issn.1001-5256.2021.05.014
Abstract(779) HTML (172) PDF (1834KB)(98) Cited By (1)
Abstract:
Original articles_Viral hepatitis
Dynamic changes of HBsAg and hepatitis B virus DNA in chronic hepatitis B patients with entecavir monotherapy for 5 years
Fengping WU, Miaoxian LI, Yikai WANG, Rui LU, Yixin LIU, Shuangsuo DANG
2021, 37(5): 1047-1052. DOI: 10.3969/j.issn.1001-5256.2021.05.015
Abstract(1001) HTML (689) PDF (1991KB)(174) Cited By (13)
Abstract:
Objective To investigate the dynamic changes of serum HBsAg and hepatitis B virus (HBV) DNA in chronic hepatitis B patients (CHB) with entecavir (ETV) monotherapy for 5 years. Methods A retrospective analysis was performed for the clinical data of 918 CHB patients who attended the Second Affiliated ...
Antiviral effect of entecavir in chronic hepatitis B patients with rtA181V/T mutation
Shuqin LI, Jing ZHOU, Yuan GAO, Xiaoyan MA, Liping WANG
2021, 37(5): 1053-1058. DOI: 10.3969/j.issn.1001-5256.2021.05.016
Abstract(555) HTML (122) PDF (1906KB)(51) Cited By (4)
Abstract:
Objective To investigate the clinical effect of entecavir (ETV) rescue treatment in chronic hepatitis B (CHB) patients at the onset of rtA181V/T mutation. Methods A total of 174 CHB patients who were treated in the outpatient and inpatient departments of The Affiliated Hospital of Xuzhou Medical Uni...
Mechanism of gamma-chain cytokines in regulating the expression of T-cell immunoglobulin and mucin domain-containing molecule 3 in CD8+ T cells of chronic hepatitis B patients
Xiaofei YANG, Linxu WANG, Changxing HUANG, Jie DONG, Haifeng HU, Zhanhu BI, Jianqi LIAN, Ye ZHANG
2021, 37(5): 1059-1064. DOI: 10.3969/j.issn.1001-5256.2021.05.017
Abstract(657) HTML (186) PDF (3290KB)(31) Cited By (4)
Abstract:
Objective To investigate the mechanism of gamma-chain (γC) cytokines in regulating the expression of T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) in CD8+ T cells of chronic hepatitis B (CHB) patients. Methods A total of 23 CHB patients who attended Tangdu Hospital, Fourth Mil...
Clinical effect of Jiedu Liangxue Jianpi prescription in treatment of patients with hepatitis B virus-associated acute-on-chronic liver failure in early and middle stages
Ke SHI, Yixin HOU, Jie HOU, Yuxin LI, Chongping RAN, Xianbo WANG
2021, 37(5): 1065-1069. DOI: 10.3969/j.issn.1001-5256.2021.05.018
Abstract(799) HTML (155) PDF (1888KB)(39) Cited By (9)
Abstract:
Objective To investigate the clinical effect of Jiedu Liangxue Jianpi prescription in the treatment of patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) in early and middle stages. Methods A total of 75 patients who were diagnosed with HBV-ACLF in early and middle ...
Value of Model for End-Stage Liver Disease score combined with platelet-to-white blood cell ratio in predicting the prognosis of patients with hepatitis B virus-associated acute-on-chronic liver failure
Xinyi GAO, Li CHEN, Jianhe GAN
2021, 37(5): 1070-1074. DOI: 10.3969/j.issn.1001-5256.2021.05.019
Abstract(891) HTML (148) PDF (1967KB)(80) Cited By (20)
Abstract:
Objective To investigate the value of Model for End-Stage Liver Disease (MELD) score combined with platelet-to-white blood cell ratio (PWR) in predicting the short-term prognosis of patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Methods A retrospective analysis...
Clinical significance of serum protoporphyrin Ⅸ measurement in patients with HBV-related chronic liver diseases
Ying ZHANG, Ruochen CHENG, Rui GUO, Xia WANG, Kaige LIU
2021, 37(5): 1075-1080. DOI: 10.3969/j.issn.1001-5256.2021.05.020
Abstract(533) HTML (207) PDF (2602KB)(34) Cited By (3)
Abstract:
Objective To investigate the value of serum protoporphyrin Ⅸ (PPIX) measurement in evaluating liver damage in patients with HBV-related chronic liver diseases. Methods A total of 110 patients who were diagnosed with HBV-related chronic liver diseases in The First Affiliated Hospital of Xi'an Medical...
Original articles_Liver fibrosis and liver cirrhosis
Clinical value of two-dimensional shear wave elastography in predicting esophageal varices in patients with hepatitis B cirrhosis by evaluating liver and spleen stiffness
Xuemei WANG, Yao ZHANG, Xueping YANG, Yue WANG, Mixue WANG
2021, 37(5): 1081-1084. DOI: 10.3969/j.issn.1001-5256.2021.05.021
Abstract(924) HTML (172) PDF (2305KB)(50) Cited By (13)
Abstract:
Objective To investigate the value of two-dimensional shear wave elastography (2D-SWE) in the noninvasive evaluation of the presence or absence of esophageal varices (EV) in patients with hepatitis B cirrhosis by liver stiffness measurement (LSM) and spleen stiffness measurement (SSM). Methods A tot...
Value of albumin-bilirubin score in predicting the prognosis of patients with liver cirrhosis and esophagogastric variceal bleeding
Dezhao LI, Jian LI, Xiaolin GUO
2021, 37(5): 1085-1090. DOI: 10.3969/j.issn.1001-5256.2021.05.022
Abstract(881) HTML (290) PDF (2209KB)(92) Cited By (20)
Abstract:
Objective To investigate the value of albumin-bilirubin (ALBI) score in evaluating the prognosis of patients with liver cirrhosis and esophagogastric variceal bleeding, and to compare it with Child-Turcotte-Pugh (CTP) score and Model for End-stage Liver Disease combined with serum sodium concentrati...
Original articles_Liver neoplasms
Effect of the expression level of diacylglycerol kinase gamma in paracancerous tissue on postoperative survival in patients with hepatocellular carcinoma
Xiangjun QIAN, Zhengyang GUO, Li WANG, Hanxiao NIE, Tao HE, Xiaoqian WANG, Baishun WAN, Mingjie YAO, Ling ZHANG
2021, 37(5): 1091-1096. DOI: 10.3969/j.issn.1001-5256.2021.05.023
Abstract(640) HTML (132) PDF (2110KB)(34)
Abstract:
Objective To investigate the effect of the expression level of diacylglycerol kinase gamma (DGKγ) in paracancerous tissue on the postoperative prognosis of patients with hepatocellular carcinoma (HCC) and its clinical value. Methods Related clinical data were collected from 78 HCC patients who were ...
Effect of aspirin on the incidence rate of liver cancer in patients with viral hepatitis: A Meta-analysis
Shun ZHU, Zhiguo LI, Shuo LI, Xu CAO, Xiaobin LI, Xiaoke LI, Yongan YE
2021, 37(5): 1097-1102. DOI: 10.3969/j.issn.1001-5256.2021.05.024
Abstract(709) HTML (234) PDF (2235KB)(67) Cited By (1)
Abstract:
Objective To evaluate the effect of the use of aspirin on the incidence rate of liver cancer in patients with viral hepatitis. Methods English databases including PubMed, Web of Science, and Cochrane Library were searched for studies on the use of aspirin and the incidence rate of liver cancer in pa...
Clinical effect of re-hepatic resection versus radiofrequency ablation in treatment of recurrent hepatocellular carcinoma in Asia: A Meta-analysis
Minjun LI, Zhujian DENG, Haotian LIU, Yuxian TENG, Rongrui HUO, Xiumei LIANG, Bangde XIANG, Lequn LI, Jianhong ZHONG
2021, 37(5): 1103-1109. DOI: 10.3969/j.issn.1001-5256.2021.05.025
Abstract(964) HTML (203) PDF (2595KB)(49) Cited By (4)
Abstract:
Objective To investigate the safety and efficacy of re-hepatic resection (rHR) versus radiofrequency ablation (RFA) in the treatment of recurrent hepatocellular carcinoma (RHCC) in Asia through a meta-analysis. Methods PubMed, CNKI, and Wanfang Data were searched for related studies published up to ...
Value of a microRNA risk score model in predicting the prognosis of hepatocellular carcinoma
Xiuhong HUANG, Xiaoli XIE, Huiqing JIANG
2021, 37(5): 1110-1115. DOI: 10.3969/j.issn.1001-5256.2021.05.026
Abstract(620) HTML (304) PDF (4272KB)(39) Cited By (1)
Abstract:
Objective To screen out the microRNAs (miRNAs) associated with the prognosis of hepatocellular carcinoma (HCC) through data mining of miRNA transcriptome data of HCC downloaded from The Cancer Genome Atlas (TCGA) database, to establish a miRNA risk score model, and to investigate its value in predic...
Effect of AU-rich element RNA-binding factor 1 on the level of glypican 3 in hepatocellular carcinoma
Ting ZHANG, Guiwen GUAN, Jing ZHANG, Fengmin LU, Xiangmei CHEN
2021, 37(5): 1116-1120. DOI: 10.3969/j.issn.1001-5256.2021.05.027
Abstract(685) HTML (154) PDF (3927KB)(26) Cited By (3)
Abstract:
Objective To investigate the effect of AU-rich element RNA-binding factor 1 (AUF1) on glypican 3 (GPC3) in hepatocellular carcinoma (HCC) and its possible mechanism. Methods TCGA-HCC gene expression data were downloaded from Broad Institute Genome Data Analysis Center, and finally 371 HCC tissue sam...
Value of preoperative microRNA-192 in peripheral blood mononuclear cells in predicting microvascular invasion of solitary hepatocellular carcinoma
Xuemei DING, Shilun WU, Wenbing SUN
2021, 37(5): 1121-1125. DOI: 10.3969/j.issn.1001-5256.2021.05.028
Abstract(669) HTML (147) PDF (1989KB)(24)
Abstract:
Objective To investigate the value of preoperative microRNA-192 (miR-192) in peripheral blood mononuclear cells (PBMCs) in predicting microvascular invasion (MVI) of solitary hepatocellular carcinoma (HCC). Methods A total of 136 patients with HCC who underwent surgical treatment in Department of He...
Effect of circRNA hsa_circ_0091579 on the proliferation, migration, and invasion of hepatoma cells
Weikai YU, Tingting FENG, Xiaobing CHEN, Jiye LUO, Wanwen FENG, Yanli WANG
2021, 37(5): 1126-1131. DOI: 10.3969/j.issn.1001-5256.2021.05.029
Abstract(1385) HTML (203) PDF (4588KB)(56) Cited By (3)
Abstract:
Objective To investigate the expression of circular RNA (cirRNA) hsa_circ_0091579 in human hepatocellular carcinoma (HCC) cell lines and its effect on the proliferation, migration, and invasion of HCC cells. Methods Human HCC cell lines SMMC-7721, Huh-7, MHCC-97H, and HepG2 and normal human liver ce...
Original articles_Other liver diseases
Association between liver fibrosis and C-peptide in patients with type 2 diabetes and nonalcoholic fatty liver disease
Jiao LIU, Caiqin REN, Yali FENG, Jirui HE
2021, 37(5): 1132-1136. DOI: 10.3969/j.issn.1001-5256.2021.05.030
Abstract(905) HTML (147) PDF (1916KB)(40) Cited By (12)
Abstract:
Objective To investigate the effect of serum C-peptide level on the progression of liver fibrosis in patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Methods A total of 484 patients with T2DM who were admitted to Department of Geriatrics, The Second Hospita...
Association between monocyte-to-high-density lipoprotein cholesterol ratio and nonalcoholic fatty liver disease
Juan WANG, Yingchun WANG, Chunyu WANG
2021, 37(5): 1137-1141. DOI: 10.3969/j.issn.1001-5256.2021.05.031
Abstract(685) HTML (119) PDF (2065KB)(48) Cited By (5)
Abstract:
Objective To investigate the association between monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and nonalcoholic fatty liver disease (NAFLD). Methods A total of 208 patients who were admitted to Department of Gastroenterology, Zhongshan Hospital Affiliated to Dalian University, from Ja...
Influencing factors for the clinical effect of emergency endoscopic therapy in treatment of acute-on-chronic liver failure with gastroesophageal variceal bleeding
Li LI, Pengpeng DING, Jianhong CHEN, Yadan WANG, Chunmei GUO, Mingming MENG, Yanling WANG, Xiaobao QI, Wenhui ZHANG, Hong LIU
2021, 37(5): 1142-1146. DOI: 10.3969/j.issn.1001-5256.2021.05.032
Abstract(625) HTML (177) PDF (1883KB)(35) Cited By (2)
Abstract:
Objective To investigate the influencing factors for the clinical effect of emergency endoscopic therapy in the treatment of patients with acute-on-chronic liver failure and gastroesophageal variceal bleeding. Methods A total of 51 patients with acute-on-chronic liver failure and gastroesophageal va...
Value of prognostic nutritional index in predicting the prognosis of patients with hepatic alveolar echinococcosis
Xiaobin CHEN, Jiqi YUAN, Zhaojun XU, Haining FAN, Lizhao HOU, Haijiu WANG, Ying ZHOU, Pengjie CHEN, Zhixin WANG
2021, 37(5): 1147-1151. DOI: 10.3969/j.issn.1001-5256.2021.05.033
Abstract(594) HTML (113) PDF (2428KB)(23) Cited By (8)
Abstract:
Objective To investigate the value of prognostic nutritional index (PNI) in predicting the prognosis of patients with hepatic alveolar echinococcosis. Methods A retrospective analysis was performed for the clinical data of 242 patients who were admitted to Department of Hepatopancreatobiliary Surger...
Effect of pretreatment with adenosine monophosphate-activated protein kinase agonist on a rat model of hepatic ischemia-reperfusion injury and related mechanism
Ningbo PAN, Xuyang ZHANG, Yu ZHANG, Longcan YANG, Xi YU, Jiwei LI, Tianhao TANG, Ping HUANG, Ying ZHANG
2021, 37(5): 1152-1157. DOI: 10.3969/j.issn.1001-5256.2021.05.034
Abstract(956) HTML (256) PDF (2519KB)(48) Cited By (7)
Abstract:
Objective To investigate the effect of pretreatment with adenosine monophosphate-activated protein kinase (AMPK) agonist on rats with hepatic ischemia-reperfusion injury (HIRI) and the possible mechanism. Methods A total of 54 healthy specific pathogen-free male Sprague-Dawley rats were randomly and...
Clinical and genetic features of neonatal intrahepatic cholestasis caused by citrin deficiency in northern China: A single-center analysis of 23 cases
Wenwen LIU, Xin MA, Meijuan WANG, Huijuan NING, Xuemei ZHONG
2021, 37(5): 1158-1163. DOI: 10.3969/j.issn.1001-5256.2021.05.035
Abstract(575) HTML (523) PDF (2205KB)(38) Cited By (1)
Abstract:
Objective To investigate the clinical features and gene mutation characteristics of neonatal intrahepatic cholestasis caused citrin deficiency (NICCD) in northern China. Methods A total of 23 pediatric patients in northern China who were diagnosed with NICCD by blood tandem mass spectrometry and/or ...
Original articles_Pancreatic diseases
Clinical and prognostic features of hypertriglyceridemic pancreatitis during pregnancy
Yuqing CHEN, Peiling LI, Lu ZHANG, Huan XU, Yan PENG, Xiaowei TANG
2021, 37(5): 1164-1168. DOI: 10.3969/j.issn.1001-5256.2021.05.036
Abstract(711) HTML (166) PDF (1881KB)(42) Cited By (7)
Abstract:
Objective To investigate the clinical and prognostic features of hypertriglyceridemic pancreatitis (HTGP) during pregnancy. Methods A total of 77 patients with acute pancreatitis in pregnancy who were admitted to The Affiliated Hospital of Southwest Medical University from January 2013 to June 2020 ...
Case reports
Acute severe hepatitis C after surgery for lung cancer: A case report
Xiaofeng LI, Yanyan ZHAO, Yongtao SUN, Wen KANG
2021, 37(5): 1169-1170. DOI: 10.3969/j.issn.1001-5256.2021.05.037
Abstract(495) HTML (195) PDF (1844KB)(24) Cited By (3)
Abstract:
Two cases of ulcerative colitis with liver injury
Hao WU, Man LIU, Na LI, Dan CHEN, Lei ZHU
2021, 37(5): 1171-1173. DOI: 10.3969/j.issn.1001-5256.2021.05.038
Abstract(611) HTML (196) PDF (3754KB)(38) Cited By (3)
Abstract:
Successful treatment of thyroid storm with liver failure and heart failure using the double plasma molecular absorption system: A case report
Tao WANG, Fenghui LI, Jing LIANG
2021, 37(5): 1174-1176. DOI: 10.3969/j.issn.1001-5256.2021.05.039
Abstract(550) HTML (192) PDF (2180KB)(31) Cited By (2)
Abstract:
A case of hereditary hemochromatosis with diabetic ketoacidosis as the manifestation
Yingyue HU, Lisha LU, Zhenmao LI, Liangping LI, Lei LEI
2021, 37(5): 1177-1179. DOI: 10.3969/j.issn.1001-5256.2021.05.040
Abstract(655) HTML (221) PDF (3389KB)(36) Cited By (1)
Abstract:
Hereditary hemochromatosis caused by mutation in the SLC40A1 gene: A case report
Chengyu ZHU, Qi CHEN, Zhongxin FENG
2021, 37(5): 1180-1182. DOI: 10.3969/j.issn.1001-5256.2021.05.041
Abstract(802) HTML (307) PDF (2385KB)(44) Cited By (1)
Abstract:
Hepatic alveolar echinococcosis misdiagnosed as intrahepatic cholangiocarcinoma: A case report
Kai ZHAO, Zhixin WANG, Shengbao WEN, Haijiu WANG, Haining FAN, Li REN
2021, 37(5): 1183-1185. DOI: 10.3969/j.issn.1001-5256.2021.05.042
Abstract(605) HTML (253) PDF (2157KB)(37) Cited By (1)
Abstract:
A case of splenic arteriovenous fistula with abdominal pain and gastrointestinal bleeding as the first symptoms
Yuanyuan CAI, Zhongwen WU, Juan LU
2021, 37(5): 1186-1188. DOI: 10.3969/j.issn.1001-5256.2021.05.043
Abstract(651) HTML (157) PDF (2876KB)(29) Cited By (1)
Abstract:
Reviews
Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA
Yiying WANG, Xichen LIU, Rongli PIAO, Junjie QIN
2021, 37(5): 1189-1192. DOI: 10.3969/j.issn.1001-5256.2021.05.044
Abstract(733) HTML (401) PDF (2143KB)(76) Cited By (1)
Abstract:
The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected...
Application of sofosbuvir in HCV-infected patients with end-stage renal disease undergoing hemodialysis
Zujiang YU, Ye ZHANG, Jianqi LIAN
2021, 37(5): 1193-1196. DOI: 10.3969/j.issn.1001-5256.2021.05.045
Abstract(681) HTML (144) PDF (1884KB)(45) Cited By (1)
Abstract:
For chronic hepatitis C patents with end-stage renal disease (ESRD) undergoing hemodialysis, most guidelines recommend the use of direct-acting antivirals containing protease inhibitor (PI), yet dialysis patients with severe liver injury are often unable to receive such treatment due to contraindica...
Influence of glucose metabolism disorder on complications associated with liver cirrhosis
Caiyun TIAN, Han HU, Guoyuan ZHANG, Shide LIN
2021, 37(5): 1197-1200. DOI: 10.3969/j.issn.1001-5256.2021.05.046
Abstract(636) HTML (205) PDF (1874KB)(56) Cited By (5)
Abstract:
Both diabetes mellitus and liver cirrhosis have high incidence rate and mortality rate around the world, and in recent ten years, scholars in China and globally have conducted many studies on the association between diabetes mellitus and liver cirrhosis. This article systematically reviews the advan...
Current status of research on hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
Gonghai CHEN, Guangchuan WANG, Chunqing ZHANG
2021, 37(5): 1201-1204. DOI: 10.3969/j.issn.1001-5256.2021.05.047
Abstract(879) HTML (236) PDF (1876KB)(83) Cited By (9)
Abstract:
Hepatic encephalopathy (HE) is a common complication after transjugular intrahepatic portosystemic shunt (TIPS), and there are still no systematic strategies for prevention and treatment at present. Based on recent studies in China and foreign countries, this article analyzes and summarizes the risk...
Current developmental status of non-surgical treatment of hepatocellular carcinoma
Zhiyuan YU, Shiyu YANG, Jiaqi LI, Yan SUN
2021, 37(5): 1205-1207. DOI: 10.3969/j.issn.1001-5256.2021.05.048
Abstract(669) HTML (125) PDF (1865KB)(57) Cited By (4)
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality in clinical practice. With the development of imaging and interventional techniques, transcatheter arterial chemoembolization and local ablation are more and more widely used for treatment and can even achi...
Pathogenesis and prevention strategy of hepatocellular carcinoma in acute intermittent porphyria
Xixi CAO, Yi REN, Simin LIU, Jing YANG
2021, 37(5): 1208-1211. DOI: 10.3969/j.issn.1001-5256.2021.05.049
Abstract(605) HTML (323) PDF (1876KB)(30) Cited By (2)
Abstract:
With the development of genetics and molecular biology, the research on acute intermittent porphyria (AIP) has been gradually deepened, and its complication hepatocellular carcinoma (HCC) has attracted more and more attention. This article mainly summarizes the research advances in the pathogenesis ...
Application of stereotactic body radiotherapy in small hepatocellular carcinoma
Wenjun LIU, Dan DU, Baojie CHEN, Ting YAO, Xianfu LI
2021, 37(5): 1212-1215. DOI: 10.3969/j.issn.1001-5256.2021.05.050
Abstract(653) HTML (481) PDF (1879KB)(46) Cited By (8)
Abstract:
At present, hepatic resection (HR) and radiofrequency ablation of (RFA) are the main radical treatment methods for small hepatocellular carcinoma (sHCC), while stereotactic body radiotherapy (SBRT) is developing rapidly and there is an increasing number of reports on the effective treatment of sHCC ...
Advances of traditional Chinese medicine in prevention and treatment of recurrence and metastasis of liver cancer
Liu LIU, Qiuluo CHENG, Changchuan BAI, Ying ZHU
2021, 37(5): 1216-1220. DOI: 10.3969/j.issn.1001-5256.2021.05.051
Abstract(1346) HTML (221) PDF (2109KB)(92) Cited By (15)
Abstract:
Great achievements have been made in traditional Chinese medicine in the prevention and treatment of liver cancer in recent years. Studies have shown that traditional Chinese medicine can reduce the recurrence and metastasis of liver cancer and prolong the survival time of patients by inhibiting cel...
Role of ghrelin and obestatin in the progression of nonalcoholic fatty liver disease
Bingbing GAO, Honghua GUO
2021, 37(5): 1221-1225. DOI: 10.3969/j.issn.1001-5256.2021.05.052
Abstract(614) HTML (227) PDF (1885KB)(36) Cited By (2)
Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a disease caused by multiple factors and can progress to liver cirrhosis and hepatocellular carcinoma. At present, the pathogenesis of NAFLD remains unclear and there are still no effective therapeutic drugs in clinical practice; therefore, it is particula...
Role of interleukin-1β in the pathogenesis of alcoholic liver disease
Hui QUAN, Yuyong JIANG
2021, 37(5): 1226-1228. DOI: 10.3969/j.issn.1001-5256.2021.05.053
Abstract(880) HTML (101) PDF (1866KB)(54) Cited By (7)
Abstract:
Alcoholic liver disease (ALD) has become the second largest liver disease after viral liver disease in China. Chronic alcohol exposure increases the production of proinflammatory factors including interleukin-1β (IL-1β), which is closely associated with the main symptoms of alcoholic hepatitis such ...
Advances in clinical research on liver disease during pregnancy
Peng XIAO, Taotao BA, Mengmeng DING, Yanhang GAO
2021, 37(5): 1229-1232. DOI: 10.3969/j.issn.1001-5256.2021.05.054
Abstract(824) HTML (316) PDF (1867KB)(139) Cited By (4)
Abstract:
According to the association between liver injury and pregnancy, liver diseases during pregnancy can be classified as pregnancy-specific liver diseases and liver diseases with pregnancy. Pregnancy-specific liver diseases refer to the liver diseases that only occur during pregnancy, while liver disea...
    

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