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Volume 37 Issue 5
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(5): 1029-1033

Chinese radiotherapy guidelines for primary hepatocellular carcinoma (2020 edition)

DOI: 10.3760/cma.j.cn371439-20201208-00001
  • Received Date: 2021-03-22
  • Accepted Date: 2021-03-22
  • Published Date: 2021-05-20
    Abstract
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  • 在肝细胞癌(HCC)的治疗中，放射治疗日益成为一种重要的治疗策略。然而，对放射治疗的抵抗是成功治疗的主要障碍之一。因此，该研究旨在阐明放射抵抗的机制，并寻找可靠的生物靶点，以提高HCC放射治疗的疗效。

    从无标记的定量蛋白质组筛选中，确定转移RNA(tRNA；鸟嘌呤-N[7]-)甲基转移酶1(METTL1)是N7-甲基鸟苷(M7G)tRNA修饰的关键酶，是HCC细胞辐射抗性的重要驱动因素。通过体外和体内功能丧失及功能获得实验分析，发现METTL1促进DNA双链断裂(DSB)修复，并使HCC细胞对电离辐射产生抵抗。

    在机制上，METTL1介导的M7G tRNA修饰选择性地调节电离辐射处理后DNA依赖的蛋白激酶催化亚基或DNA连接酶Ⅳ的翻译，从而导致非同源末端连接(NHEJ)介导的DNA DSB修复效率提高。临床上，肿瘤组织中METTL1的高表达与接受放射治疗的HCC患者的不良预后显著相关。

    研究表明，METTL1是电离辐射治疗后HCC细胞基于NHEJ的DNA修复的关键增强剂。这些发现有助于了解tRNA修饰在信使RNA翻译控制中的作用。

    摘译自LIAO J, YI Y, YUE X, et al. Methyltransferase 1 is required for nonhomologous end-joining repair and renders hepatocellular carcinoma resistant to radiotherapy[J]. Hepatology, 2022. DOI: 10.1002/hep.32615. [Online ahead of print]

    (吉林大学第一医院感染病中心肝病科  韩雨金  金清龙  报道)

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  • 中国原发性肝细胞癌放射治疗指南（2020年版） 附录1-4.pdf
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    The first journal specializing in hepatobiliary and pancreatic diseases in China

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