中文｜English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 4
Apr.  2021
Turn off MathJax
Article Contents
Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(4): 921-924

Association of hepatitis B and hepatitis C with type 2 diabetes mellitus

DOI: 10.3969/j.issn.1001-5256.2021.04.042

  • Department of Biochemistry and Molecular Biology, Guilin Medical University, Guilin, Guangxi 541004, China

  • Received Date: 2020-11-10
  • Accepted Date: 2020-12-16
  • Published Date: 2021-04-20
    Abstract

  • Hepatitis B, hepatitis C, and type 2 diabetes mellitus (T2DM) are serious public health issues worldwide. This article analyzes the association of hepatitis B and hepatitis C with T2DM. The analysis shows that on the one hand, both hepatitis B and hepatitis C promote the pathogenesis of T2DM, which involves viral infection inhibiting insulin signal transduction as well as glucose uptake and glycogen synthesis in insulin target cells; on the other hand, patients with T2DM are prone to hepatitis B and hepatitis C, which may be associated with multiple organ dysfunction caused by diabetes.

     

    • FullText(HTML)
  • loading
    • References(50)
  • [1]
    World Health Organization. Global hepatitis report, 2017[EB/OL]. [2020-11-10]. https://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/externalicon.
    [2]
    International Diabetes Federation. Diabetes Atlas. 9th Edition. 2019[EB/OL]. [2020-11-10]. https://diabetesatlas.org/data/en/world/International.
    [3]
    FABIANI S, FALLAHI P, FERRARI SM, et al. Hepatitis C virus infection and development of type 2 diabetes mellitus: Systematic review and meta-analysis of the literature[J]. Rev Endocr Metab Disord, 2018, 19(4): 405-420. DOI: 10.1007/s11154-017-9440-1.
    [4]
    HONG YS, CHANG Y, RYU S, et al. Hepatitis B and C virus infection and diabetes mellitus: A cohort study[J]. Sci Rep, 2017, 7(1): 4606. DOI: 10.1038/s41598-017-04206-6.
    [5]
    HAN BF, YUAN QL, LIU J, et al. The risk of hepatitis B virus infection in people with diabetes mellitus: A meta-analysis[J]. Chin J Prevent Med, 2018, 52(7): 748-752. DOI: 10.3760/cma.j.issn.0253-9624.2018.07.013.

    韩冰峰, 袁千里, 刘姜, 等. 糖尿病患者感染HBV风险的Meta分析[J]. 中华预防医学杂志, 2018, 52(7): 748-752. DOI: 10.3760/cma.j.issn.0253-9624.2018.07.013.
    [6]
    SINGH KK, PANDA SK, SHALIMAR, et al. Patients with diabetes mellitus are prone to develop severe hepatitis and liver failure due to hepatitis virus infection[J]. J Clin Exp Hepatol, 2013, 3(4): 275-280. DOI: 10.1016/j.jceh.2013.11.003.
    [7]
    ZHANG J, SHEN Y, CAI H, et al. Hepatitis B virus infection status and risk of type 2 diabetes mellitus: A meta-analysis[J]. Hepatol Res, 2015, 45(11): 1100-1109. DOI: 10.1111/hepr.12481.
    [8]
    CAI C, ZENG J, WU H, et al. Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis[J]. Exp Ther Med, 2015, 10(2): 693-698. DOI: 10.3892/etm.2015.2537.
    [9]
    WU D. Correlation of viral load of hepatitis B with the gestation period and the development of diabetes mellitus[J]. Saudi J Biol Sci, 2019, 26(8): 2022-2025. DOI: 10.1016/j.sjbs.2019.08.009.
    [10]
    GILES ML, DAVEY MA, WALLACE EM. Chronic hepatitis B infection and the risk of gestational diabetes: A cross-sectional study[J]. BJOG, 2020, 127(9): 1147-1152. DOI: 10.1111/1471-0528.16217.
    [11]
    YE J, HU X, WU T, et al. Insulin resistance exhibits varied metabolic abnormalities in nonalcoholic fatty liver disease, chronic hepatitis B and the combination of the two: A cross-sectional study[J]. Diabetol Metab Syndr, 2019, 11: 45. DOI: 10.1186/s13098-019-0440-z.
    [12]
    JI D, HAN P, ZHANG J, et al. Down-regulating effect of hepatitis B virus pre-S2 protein upon insulin receptor gene promoter[J]. Chin J Prevent Med, 2009, 89(43): 3069-3073. DOI: 10.3760/cma.j.issn.0376-2491.2009.43.013.

    纪冬, 韩萍, 张健, 等. 乙型肝炎病毒前S2蛋白下调胰岛素受体启动子的研究[J]. 中华医学杂志, 2009, 89(43): 3069-3073. DOI: 10.3760/cma.j.issn.0376-2491.2009.43.013.
    [13]
    BARTHEL SR, MEDVEDEV R, HEINRICH T, et al. Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor[J]. Cell Mol Life Sci, 2016, 73(21): 4121-4140. DOI: 10.1007/s00018-016-2259-1.
    [14]
    KIM HY, CHO HK, YOO SK, et al. Hepatic STAMP2 decreases hepatitis B virus X protein-associated metabolic deregulation[J]. Exp Mol Med, 2012, 44(10): 622-632. DOI: 10.3858/emm.2012.44.10.071.
    [15]
    RAWAT S, BOUCHARD MJ. The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival[J]. J Virol, 2015, 89(2): 999-1012. DOI: 10.1128/JVI.02440-14.
    [16]
    CHUNG W, KIM M, de la MONTE S, et al. Activation of signal transduction pathways during hepatic oncogenesis[J]. Cancer Lett, 2016, 370(1): 1-9. DOI: 10.1016/j.canlet.2015.09.016.
    [17]
    ZHU M, GUO J, LI W, et al. HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells[J]. BMC Cancer, 2015, 15: 362. DOI: 10.1186/s12885-015-1384-9.
    [18]
    KHATTAR E, MUKHERJI A, KUMAR V. Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation[J]. FEBS J, 2012, 279(7): 1220-1230. DOI: 10.1111/j.1742-4658.2012.08514.x.
    [19]
    PIRACHA ZZ, KWON H, SAEED U, et al. Sirtuin 2 isoform 1 enhances hepatitis B virus RNA transcription and DNA synthesis through the AKT/GSK-3β/β-catenin signaling pathway[J]. J Virol, 2018, 92(21): e00955-18. DOI: 10.1128/JVI.00955-18.
    [20]
    LI C, LIN C, CONG X, et al. PDK1-WNK1 signaling is affected by HBx and involved in the viability and metastasis of hepatic cells[J]. Oncol Lett, 2018, 15(4): 5940-5946. DOI: 10.3892/ol.2018.8001.
    [21]
    ZHOU Y, CUI Y, DENG H, et al. Association between hepatitis B virus infection and metabolic syndrome: A retrospective cohort study in Shanghai, China[J]. BMC Public Health, 2014, 14: 516. DOI: 10.1186/1471-2458-14-516.
    [22]
    LI Y, ZHAO Y, WU J. Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome: A meta-analysis[J]. PLoS One, 2017, 12(5): e0177713. DOI: 10.1371/journal.pone.0177713.
    [23]
    KUO YH, KEE KM, WANG JH, et al. Association between chronic viral hepatitis and metabolic syndrome in southern Taiwan: A large population-based study[J]. Aliment Pharmacol Ther, 2018, 48(9): 993-1002. DOI: 10.1111/apt.14960.
    [24]
    WANG CC, CHENG PN, KAO JH. Systematic review: Chronic viral hepatitis and metabolic derangement[J]. Aliment Pharmacol Ther, 2020, 51(2): 216-230. DOI: 10.1111/apt.15575.
    [25]
    LIU J, SHI JP. Diagnosis and treatment of hepatitis B virus infection complicated by metabolic syndrome[J]. J Clin Hepatol, 2016, 32(11): 2039-2042. DOI: 10.3969/j.issn.1001-5256.2016.11.004.

    刘静, 施军平. HBV感染合并代谢综合征的诊治[J]. 临床肝胆病杂志, 2016, 32(11): 2039-2042. DOI: 10.3969/j.issn.1001-5256.2016.11.004.
    [26]
    ZHANG X, ZHU X, JI Y, et al. Increased risk of hepatitis B virus infection amongst individuals with diabetes mellitus[J]. Biosci Rep, 2019, 39(3): BSR20181715. DOI: 10.1042/BSR20181715.
    [27]
    YOUNOSSI Z, STEPANOVA M, SAAB S, et al. The association of hepatitis C virus infection and post-liver transplant diabetes: Data from 17: BSR20181715000 HCV-infected transplant recipients[J]. Aliment Pharmacol Ther, 2015, 41(2): 209-217. DOI: 10.1111/apt.13027.
    [28]
    BANKS DE, BOGLER Y, BHUKET T, et al. Significant disparities in risks of diabetes mellitus and metabolic syndrome among chronic hepatitis C virus patients in the U. S[J]. Diabetes Metab Syndr, 2017, 11 Suppl 1: s153-s158. DOI: 10.1016/j.dsx.2016.12.025.
    [29]
    CHEN Y, JI H, SHAO J, et al. Different hepatitis C virus infection statuses show a significant risk of developing type 2 diabetes mellitus: A network meta-analysis[J]. Dig Dis Sci, 2020, 65(7): 1940-1950. DOI: 10.1007/s10620-019-05918-7.
    [30]
    GUO X, JIN M, YANG M, et al. Type 2 diabetes mellitus and the risk of hepatitis C virus infection: A systematic review[J]. Sci Rep, 2013, 3: 2981. DOI: 10.1038/srep02981.
    [31]
    GEBREKRISTOS G, TEWELDEMEDHIN M, HAGOS L, et al. Hepatitis C virus infections and associated risk factors in patients with diabetes mellitus; case control study in North West Tigray, Ethiopia[J]. BMC Res Notes, 2018, 11(1): 873. DOI: 10.1186/s13104-018-3983-4.
    [32]
    BANERJEE S, SAITO K, AIT-GOUGHOULTE M, et al. Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance[J]. J Virol, 2008, 82(6): 2606-2612. DOI: 10.1128/JVI.01672-07.
    [33]
    KAWAGUCHI T, YOSHIDA T, HARADA M, et al. Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3[J]. Am J Pathol, 2004, 165(5): 1499-1508. DOI: 10.1016/S0002-9440(10)63408-6.
    [34]
    PARVAIZ F, MANZOOR S, IQBAL J, et al. Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis[J]. World J Gastroenterol, 2015, 21(43): 12361-12369. DOI: 10.3748/wjg.v21.i43.12361.
    [35]
    HETTA HF, ELKADY A, MORSY KH, et al. Serum level of IL17a among cirrhotic hepatitis C virus infected patients with incidence of diabetes mellitus[J]. Egypt J Immunol, 2017, 24(1): 79-88. http://europepmc.org/abstract/MED/29120580
    [36]
    LEMOINE M, CHEVALIEZ S, BASTARD JP, et al. Association between IL28B polymorphism, TNFα and biomarkers of insulin resistance in chronic hepatitis C-related insulin resistance[J]. J Viral Hepat, 2015, 22(11): 890-896. DOI: 10.1111/jvh.12408.
    [37]
    SHINTANI Y, FUJIE H, MIYOSHI H, et al. Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance[J]. Gastroenterology, 2004, 126(3): 840-848. DOI: 10.1053/j.gastro.2003.11.056.
    [38]
    KASAI D, ADACHI T, DENG L, et al. HCV replication suppresses cellular glucose uptake through down-regulation of cell surface expression of glucose transporters[J]. J Hepatol, 2009, 50(5): 883-894. DOI: 10.1016/j.jhep.2008.12.029.
    [39]
    DAS P, BISWAS S, MUKHERJEE S, et al. Association of oxidative stress and obesity with insulin resistance in type 2 diabetes mellitus[J]. Mymensingh Med J, 2016, 25(1): 148-152. http://www.ncbi.nlm.nih.gov/pubmed/26931265
    [40]
    DENG L, SHOJI I, OGAWA W, et al. Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway[J]. J Virol, 2011, 85(17): 8556-8568. DOI: 10.1128/JVI.00146-11.
    [41]
    SMIRNOVA OA, IVANOVA ON, BARTOSCH B, et al. Hepatitis C virus NS5A protein triggers oxidative stress by inducing NADPH oxidases 1 and 4 and cytochrome P450 2E1[J]. Oxid Med Cell Longev, 2016, 2016: 8341937. DOI: 10.1155/2016/8341937.
    [42]
    YANG Y, WANG Y, KONG Y, et al. Carnosine prevents type 2 diabetes-induced osteoarthritis through the ROS/NF-κB pathway[J]. Front Pharmacol, 2018, 9: 598. DOI: 10.3389/fphar.2018.00598.
    [43]
    ANTICOLI S, AMATORE D, MATARRESE P, et al. Erratum to "Counteraction of HCV-induced oxidative stress concurs to establish chronic infection in liver cell cultures"[J]. Oxid Med Cell Longev, 2019, 2019: 3712969. DOI: 10.1155/2019/3712969.
    [44]
    SHOJI I, DENG L, MATSUI C, et al. Hepatitis C virus-induced glucose metabolic disorder[J]. Uirusu, 2015, 65(2): 263-268. DOI: 10.2222/jsv.65.263.
    [45]
    CHOI HY, KIM Y, CHO H, et al. Risk of diabetes in viral hepatitis B or C patients compared to that in noninfected individuals in Korea, 2002-2013: A population-based cohort study[J]. J Viral Hepat, 2018, 25(3): 272-280. DOI: 10.1111/jvh.12815.
    [46]
    CHEN YY, FANG WH, WANG CC, et al. Increased body fat percentage in patients with hepatitis B and C virus infection[J]. PLoS One, 2018, 13(7): e0200164. DOI: 10.1371/journal.pone.0200164.
    [47]
    LIN PY, CHEN SC, LO TC, et al. Dual infection with hepatitis B virus and hepatitis C virus correlated with type 2 diabetes mellitus[J]. Exp Clin Endocrinol Diabetes, 2020, 128(1): 38-42. DOI: 10.1055/a-0794-6135
    [48]
    JIN Y, GAO H, CHEN H, et al. Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues[J]. Cancer Lett, 2013, 335(2): 447-454. DOI: 10.1016/j.canlet.2013.03.001.
    [49]
    SHIKE H, KADRY Z, IMAMURA-KAWASAWA Y, et al. Hepatitis C virus (HCV) RNA level in plasma and kidney tissue in HCV antibody-positive donors: Quantitative comparison[J]. Clin Transplant, 2018, 32(9): e13358. DOI: 10.1111/ctr.13358.
    [50]
    GUO CH, SUN TT, WENG XD, et al. The investigation of glucose metabolism and insulin secretion in subjects of chronic hepatitis B with cirrhosis[J]. Int J Clin Exp Pathol, 2015, 8(10): 13381-13386. http://europepmc.org/abstract/MED/26722544
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (641) PDF downloads(60) Cited by()
    Proportional views
    Related
        

    The first journal specializing in hepatobiliary and pancreatic diseases in China

    Supervisor：Ministry of Education of the People's Republic of China

    Sponsor：Jilin University

    Academic Support: Chinese Society of Hepatology，Chinese Medical Association

    Address: 461 Xinjiang Road, Changchun

    Submit：0431-88782044

    Peer review：0431-88783542

    Email：lcgdb@vip.163.com

    About Journal

    Submission Guideline

    Journal Online

    Hepatobiliary College

    Guidelines

    YesterdayIP[]YesterdayPV[]TodayIP[]TodayPV[]Online[]

    Website Design © 2020 Editorial Board of Journal of Clinical Hepatology 吉ICP备10000617号-1 Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return