2024 No. 12

Vol.40 No.12 (290 in total) Dec. 2024

Theme Issue: Surgical Treatment of Biliary Tract Malignancies: Opportunities and Challenges

Executive Chief Editor: TANG Zhaohui

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

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Editorial

The research on early-onset intrahepatic cholangiocarcinoma should be taken seriously

Delong QIN, Jialu CHEN, Yue TANG, Zonglong LI, Zhaohui TANG, Zhiwei QUAN

2024, 40(12): 2345-2350. DOI: 10.12449/JCH241201

Abstract(350)

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Abstract:
Intrahepatic cholangiocarcinoma （ICC） is a highly malignant biliary tumor， and early-onset ICC （EOICC） refers to ICC with an age of ≤50 years at the time of confirmed diagnosis and often has a higher clinical stage and more significant biological invasiveness. At present， the incidence rate of EOICC...

Expert Forum

Several issues in the surgical treatment of intrahepatic cholangiocarcinoma

Anfeng SI, Zhengqing LEI, Zhangjun CHENG

2024, 40(12): 2351-2357. DOI: 10.12449/JCH241202

Abstract(297)

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Abstract:
Intrahepatic cholangiocarcinoma （ICC） ranks second among malignant liver tumors and has high malignancy and poor prognosis. Currently， surgical treatment remains the only potentially curative therapy for ICC， but with a relatively low R0 resection rate and a short recurrence-free survival time after...

Feasibility and safety of laparoscopic radical surgery for intrahepatic cholangiocarcinoma

Qihui ZENG, Fuyu LI

2024, 40(12): 2358-2360. DOI: 10.12449/JCH241203

Abstract(289)

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Abstract:
Endoscopic techniques has been widely used in radical surgical resection of various tumors， but there are still controversies over the application of laparoscopy in radical treatment of intrahepatic cholangiocarcinoma. In recent years， major medical centers have made many attempts to solve this prob...

Advances in treatment decision-making for extrahepatic recurrence of intrahepatic cholangiocarcinoma

Yihang WANG, Jiangtao LI

2024, 40(12): 2361-2365. DOI: 10.12449/JCH241204

Abstract(335)

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There has been a constant increase in the incidence rate of intrahepatic cholangiocarcinoma in China， and as a highly fatal malignancy， it often has an extremely poor prognosis. Surgical resection is the only possible way to cure this disease， but postoperative recurrence rate reaches as high as 50%...

Surgical treatment of gallbladder cancer： Current status and advances

Xiaoyu YIN, Qiongcong XU

2024, 40(12): 2366-2370. DOI: 10.12449/JCH241205

Abstract(412)

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Abstract:
Gallbladder cancer is a malignant tumor with an extremely poor prognosis， and radical surgery remains the only potentially curative treatment method for this disease. For stage Tis and T1a gallbladder cancer， cholecystectomy alone can achieve a curative effect； for stage T1b-T2 gallbladder cancer， r...

Guideline

Guideline for diagnosis and treatment of liver failure （2024 version）

Liver Failure and Artificial Liver Group， Chinese Society of Infectious Diseases， Chinese Medical Association, Severe Liver Disease and Artificial Liver Group， Chinese Society of Hepatology， Chinese Medical Association

2024, 40(12): 2371-2387. DOI: 10.12449/JCH241206

Abstract(1148)

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Abstract:
Liver failure is a severe clinical syndrome of liver disease with an extremely high mortality rate. Over the years， scholars worldwide have continuously investigated various aspects of liver failure， including its definition， etiology， classification， types， diagnosis and treatment， and prognostic a...

Guideline Interpretation

Interpretation of guideline for diagnosis and treatment of liver failure （2024 version）

Tao HAN

2024, 40(12): 2388-2391. DOI: 10.12449/JCH241207

Abstract(1273)

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Abstract:
In 2024， Liver Failure and Artificial Liver Group， Chinese Society of Infectious Diseases， Chinese Medical Association and Chinese Society of Hepatology， Chinese Medical Association updated Guideline for diagnosis and treatment of liver failure （2018 version）. Guideline for diagnosis and treatment o...

Viral Hepatitis

Noninvasive diagnostic indicators for histologically defined immune tolerance state in patients with chronic HBV infection and establishment and assessment of related models

Xinyu DU, Jia LI, Bei JIANG, Kunyu ZHAO, Yue HU, Fengmei WANG, Fengmin LU

2024, 40(12): 2392-2398. DOI: 10.12449/JCH241208

Abstract(319)

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Abstract:
Objective The natural history of chronic HBV infection often involves a histologically defined immune tolerance state， and once such immune tolerance state is broken， antiviral therapy should be initiated immediately. This study aims to investigate the correlation between immune-mediated liver injur...

Value of Δtotal bilirubin-alpha-fetoprotein scoring model in predicting the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

Yuqi CHEN, Chunyan LI, Shanhong TANG

2024, 40(12): 2399-2405. DOI: 10.12449/JCH241209

Abstract(348)

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Abstract:
Objective To investigate the association of the dynamic changes of serum total bilirubin （ΔTBil） and alpha-fetoprotein （AFP） with the short-term prognosis of patients with hepatitis B virus-associated acute-on-chronic liver failure （HBV-ACLF）， to establish a new scoring model， and to investigate the...

Fatty Liver Disease

Quality assessment of randomized controlled trials of compound traditional Chinese medicine prescriptions in treatment of nonalcoholic steatohepatitis in 2018—2023

Weiwei YAO, Ruimin JIAO, Kejia LIU, Shuai XU, Li LI, Hong YOU, Jingjie ZHAO

2024, 40(12): 2406-2414. DOI: 10.12449/JCH241210

Abstract(342)

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Abstract:
Objective To assess the quality of randomized controlled trials （RCTs） of compound traditional Chinese medicine （TCM） prescriptions in the treatment of nonalcoholic steatohepatitis （NASH）， and to provide recommendations for standardizing the design and reporting of RCTs in this field. Methods Databa...

Autoimmune Liver Disease

Effect of ganoderic acid A on a mouse model of concanavalin A-induced acute immune liver injury and its mechanism

Yi CUI, Fengjie QIAO, Jiahao QIU, Yufei LIU, Zhujun GAO, Zhi SHANG, Yueqiu GAO

2024, 40(12): 2415-2423. DOI: 10.12449/JCH241211

Abstract(284)

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Abstract:
Objective To investigate the therapeutic effect of ganoderic acid A （GA-A） on a mouse model of concanavalin A （ConA）-induced autoimmune hepatitis （AIH）. Methods A total of 35 mice were randomly divided into control group （NC group）， model group （ConA group）， and low-， middle-， and high-dose GA-A tre...

Liver Fibrosis and Liver Cirrhosis

Effectiveness of fibrosis-4 versus aspartate aminotransferase-to-platelet ratio index in evaluating liver fibrosis degree in patients with chronic HBV infection

Xiaoting LI, Bobin HU, Hongyu LIU, Chao JIN, Cailian CAI, Keshan WANG, Yanchun WEI, Jianning JIANG, Minghua SU

2024, 40(12): 2424-2429. DOI: 10.12449/JCH241212

Abstract(310)

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Abstract:
Objective To investigate the performance of fibrosis-4 （FIB-4） versus aspartate aminotransferase-to-platelet ratio index （APRI） in predicting advanced liver fibrosis and disease progression in patients with chronic HBV infection. Methods A total of 497 patients with chronic HBV infection who underwe...

Influencing factors for rebleeding after endoscopic therapy in patients with liver cirrhosis receiving secondary prevention of gastroesophageal varices

Shuang ZHAO, Yuxuan ZHU, Yue LIU, Jing WANG, Qun LI, Minghui WANG, Qianqian DONG, Feifei FAN, Xiaofeng LIU

2024, 40(12): 2430-2440. DOI: 10.12449/JCH241213

Abstract(280)

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Objective To investigate the influencing factors for rebleeding after endoscopic therapy and the effect of the number of sequential treatment sessions on postoperative rebleeding in patients with liver cirrhosis receiving secondary prevention of gastroesophageal varices （GOV）. Methods A total of 1 7...

Liver Neoplasm

Risk factors for liver cancer in chronic hepatitis B patients and construction of a nomogram prediction model

Yichen ZHU, Chunxia SHA, Chunsun FAN, Tiejun ZHANG

2024, 40(12): 2441-2449. DOI: 10.12449/JCH241214

Abstract(413)

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Abstract:
Objective To investigate the risk factors for liver cancer in patients with chronic hepatitis B （CHB） in the Qidong Chronic Hepatitis B cohort， and to construct a nomogram model for predicting the risk of liver cancer in CHB patients. Methods A structured questionnaire survey was conducted among t...

Value of modified albumin-bilirubin grade in predicting the prognosis of patients with Child-Pugh class A unresectable hepatocellular carcinoma after transcatheter arterial chemoembolization combined with immunotherapy and anti-angiogenic drugs

Jiaqing LI, Xiaoyang XU, Zexin HU, Shen ZHANG, Binyan ZHONG, Xiaoli ZHU

2024, 40(12): 2450-2456. DOI: 10.12449/JCH241215

Abstract(270)

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Abstract:
Objective To investigate the ability of the modified albumin-bilirubin （mALBI） grade in predicting the prognosis of patients with Child-Pugh A unresectable hepatocellular carcinoma （uHCC） after transcatheter arterial chemoembolization （TACE） combined with immunotherapy and anti-angiogenic drugs （her...

Efficacy of drug-eluting beads-transarterial chemoembolization combined with infusion chemotherapy via superior mesenteric artery in treatment of hepatocellular carcinoma complicated by portal vein tumor thrombus

Qianxin HUANG, Bin SHEN, Jinchang XIAO, Zhikang GAO, Duntao LYU, Yan LI, Hao XU, Qingqiao ZHANG

2024, 40(12): 2457-2463. DOI: 10.12449/JCH241216

Abstract(232)

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Abstract:
Objective To investigate the efficacy of drug-eluting beads-transarterial chemoembolization （D-TACE） combined with infusion chemotherapy via superior mesenteric artery versus D-TACE alone in the treatment of hepatocellular carcinoma （HCC） complicated by portal vein tumor thrombus （PVTT）. Methods A r...

Clinical efficacy of liver venous deprivation versus portal vein embolization in treatment of liver cancer with insufficient residual liver volume： A Meta-analysis

Kaifeng YAN, Xiaojie HU, Hong LIU

2024, 40(12): 2464-2472. DOI: 10.12449/JCH241217

Abstract(226)

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Objective To systematically evaluate the efficacy and prognosis of liver venous deprivation （LVD） versus portal vein embolization （PVE） in the treatment of hepatic malignancies with insufficient residual liver volume. Methods This study was conducted according to PRISMA guidelines， with a PROSPERO r...

Establishment of a risk model based on immunogenic cell death-related genes and its value in predicting the prognosis and tumor microenvironment characteristics of hepatocellular carcinoma

Jun LIU, Ling WANG, Yuhuan JIANG, Jingzhi WANG, Huiming LI

2024, 40(12): 2473-2483. DOI: 10.12449/JCH241218

Abstract(252)

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Objective To identify immunogenic cell death （ICD）-related genes in hepatocellular carcinoma （HCC）， and to establish a scoring model based on these genes for predicting the prognosis and tumor microenvironment characteristics of HCC. Methods The Cancer Genome Atlas database was used to obtain HCC da...

Other Liver Disease

Efficacy and safety of N-acetylcysteine in treatment of severe alcoholic hepatitis

Fangjiao SONG, Tianjiao XU, Yirui YIN, Hua TIAN, Sa LYU, Shaoli YOU, Shaojie XIN, Bing ZHU

2024, 40(12): 2484-2491. DOI: 10.12449/JCH241219

Abstract(324)

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Objective To investigate the efficacy and safety of N-acetylcysteine （NAC） in the treatment of severe alcoholic hepatitis （SAH）， and to provide a basis for clinical medication for SAH. Methods A prospective randomized controlled trial was conducted among 172 SAH patients with a Maddrey discriminant ...

Pancreatic Disease

Influence of serum cumulative triglyceride exposure on the risk of acute pancreatitis

Afang SU, Xiaozhong JIANG, Yunshui ZHANG, Shouling WU, Guangjian LI

2024, 40(12): 2492-2498. DOI: 10.12449/JCH241220

Abstract(290)

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Objective To investigate the association between cumulative triglyceride （cumTG） exposure and the risk of acute pancreatitis （AP）. Methods A prospective study was conducted for a cohort of 56 883 workers from Kailuan Group who participated in annual physical examination for three consecutive times i...

Review

Research advances in chronic hepatitis B with metabolic dysfunction-associated steatotic liver disease

Ke YIN, Yuyun SONG, Feng LIU

2024, 40(12): 2499-2504. DOI: 10.12449/JCH241221

Abstract(390)

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Abstract:
Chronic hepatitis B （CHB） and fatty liver disease are common chronic liver diseases in China. With the changes in lifestyle， the number of patients with CHB and metabolic dysfunction-associated steatotic liver disease （MASLD） is increasing year by year. Both CHB and MASLD may lead to adverse events ...

Role of peripheral clock genes in the progression， prevention， and treatment of nonalcoholic steatohepatitis

Siyan LIU, Jingyi TIAN, Yuyang HUANG, Tianqi GU, Mingyue DENG, Pan YANG

2024, 40(12): 2505-2512. DOI: 10.12449/JCH241222

Abstract(241)

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Abstract:
As a severe clinical manifestation of nonalcoholic fatty liver disease， nonalcoholic steatohepatitis （NASH） is characterized by lipid deposition and inflammatory damage in the liver. At present， clinical medications for NASH are still in the exploratory phase， and it is urgent to make progress. Rece...

Mechanism of action of disulfidptosis in nonalcoholic fatty liver disease

Lisha YAN, Yu CHEN, Xueshi WANG, Xianmin FENG, Jie SUN

2024, 40(12): 2513-2517. DOI: 10.12449/JCH241223

Abstract(240)

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Abstract:
Disulfidptosis is a novel pattern of cell death caused by disulfide stress and inadequate NADPH. Nonalcoholic fatty liver disease （NAFLD） is a group of metabolic diseases with the main pathological feature of fatty infiltration， and it is closely associated with insulin resistance and genetic suscep...

Role of neuroimmune communication via the gut-brain axis in the pathogenesis of hepatic encephalopathy

Yong LIN, Jiongfen LI, Feiyan LI, Yuanqin DU, Meiyan LIU, Minggang WANG, Fuli LONG, Na WANG, Dewen MAO

2024, 40(12): 2518-2523. DOI: 10.12449/JCH241224

Abstract(431)

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Hepatic encephalopathy （HE） is a common severe liver disease syndrome in clinical practice and is one of the critical and severe diseases in internal medicine， and more than half of liver failure patients diagnosed with overt HE have a survival time of less than 1 year. A comprehensive analysis of t...

Molecular mechanism of lenvatinib resistance in hepatocellular carcinoma

Xiaomeng YAO, Keke SUN, Yunkai LIN, Hui WANG, Liwei DONG, Lei CHEN, Heping HU

2024, 40(12): 2524-2530. DOI: 10.12449/JCH241225

Abstract(400)

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Hepatocellular carcinoma is the most common malignancy of the liver and poses serious health burdens on China and the whole world. However， most patients with hepatocellular carcinoma are already in the advanced stage at the time of diagnosis， with fewer opportunities for surgery and limited treatme...

Effect of amino acid metabolic reprogramming on immune microenvironment of hepatocellular carcinoma

Xiaoli LIU, Qinwen TAN, Jian XU, Huanling CHEN, Jie YU, Lu LU, Mingkan DAI, Jingjing HUANG, Hongna HUANG, Dewen MAO

2024, 40(12): 2531-2537. DOI: 10.12449/JCH241226

Abstract(327)

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Tumor immune microenvironment is a local external tumor environment composed of tumor immune cells and the cytokines secreted by these cells， and it plays a regulatory role in the development and progression of tumors. In the treatment of hepatocellular carcinoma， amino acid metabolism and its repro...

Immunological mechanism of drug-induced liver injury

Yu WANG, Shuang LI, Chenghai LIU

2024, 40(12): 2538-2542. DOI: 10.12449/JCH241227

Abstract(304)

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Drug-induced liver injury （DILI） has a complex mechanism involving various pathways with a synergistic effect on each other and a causal relationship with each other， among which immune response plays an important role in the pathogenesis of DILI. In the context of genetic background， drug active me...

Current status of ex vivo liver resection and autotransplantation in treatment of benign liver lesions

Shuai ZHANG, Fazhu FEI, Zhixin WANG, Haining FAN, Haijiu WANG, Lizhao HOU

2024, 40(12): 2543-2547. DOI: 10.12449/JCH241228

Abstract(257)

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Benign liver lesions mainly include hepatic hemangioma， focal nodular hyperplasia of the liver， hepatocellular adenoma， and hepatic angiomyolipoma. Hepatic alveolar echinococcosis is a type of parasitic disease， and since it mainly occurs in the liver， it is also a benign lesion of the liver. The cl...

Comprehensive treatment of pancreatic cancer based on multidisciplinary diagnosis and treatment

Tantu MA, Xingfei LI, Tao LI

2024, 40(12): 2548-2552. DOI: 10.12449/JCH241229

Abstract(248)

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Pancreatic cancer is a common malignant tumor of the digestive tract， and the incidence of pancreatic cancer has been gradually increasing in recent years. The main pathological types of pancreatic cancer include ductal adenocarcinoma， small gland carcinoma， and acinar cell carcinoma， among which du...

Introduction of High - quality Articles in Foreign Journals

Hepatology International｜Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses

2024, 40(12): 2360-2360. DOI: 10.12449/JCH2412.gwqkjpwzjj1

Abstract(147)

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Hepatology International｜Clinical characteristics and managements of congenital hepatic hemangioma: A cohort study of 211 cases

2024, 40(12): 2440-2440. DOI: 10.12449/JCH2412.gwqkjpwzjj2

Abstract(153)

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