Advances in treatment decision-making for extrahepatic recurrence of intrahepatic cholangiocarcinoma

Yihang WANG; Jiangtao LI

doi:10.12449/JCH241204

Volume 40 Issue 12

Dec. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2024 > 40(12): 2361-2365

PDF( 598 KB)

Advances in treatment decision-making for extrahepatic recurrence of intrahepatic cholangiocarcinoma

DOI: 10.12449/JCH241204

Yihang WANG,
Jiangtao LI^{,
,}

Department of Hepato-Biliary-Pancreatic Surgery，The Second Affiliated Hospital of Zhejiang University School of Medicine，Hangzhou 310009，China

Research funding:

Key Research and Development Program of Zhejiang Province (2024C03172)

More Information

Corresponding author: LI Jiangtao， zjulijiangtao@163.com （ORCID： 0000-0001-7538-2910）
Received Date: 2024-10-15
Accepted Date: 2024-11-14
Published Date: 2024-12-25

Abstract

Abstract

There has been a constant increase in the incidence rate of intrahepatic cholangiocarcinoma in China， and as a highly fatal malignancy， it often has an extremely poor prognosis. Surgical resection is the only possible way to cure this disease， but postoperative recurrence rate reaches as high as 50%‍ ‍—‍ ‍70%. While recurrence is commonly observed in the liver， 15%‍ ‍—‍ ‍30% of patients may experience extrahepatic recurrence. There are relatively few studies in the treatment strategies for extrahepatic recurrence， and there are still no clear guidelines for recommendation. Chemotherapy is currently the main treatment method for this disease. Studies have shown that some patients man achieve a prolonged survival time through surgical resection of extrahepatic recurrence sites， and in particular， such surgery is more feasible in patients with single focal lesion during recurrence. Nevertheless， surgery is only suitable to a small number of patients， and most patients still need to rely on systemic therapy and local treatment. Through a comprehensive analysis of related articles， this article summarizes the key influencing factors for extrahepatic recurrence， discusses the indications for surgery， and emphasizes the importance of individualized treatment strategies， in order to provide a reference for future treatment modalities.
- Cholangiocarcinoma,
- Neoplasm Recurrence， Local,
- Therapeutics

FullText(HTML)

References(39)

References

[1]	XIE CB, SHI D, LIN HL, et al. Spatial patterns of gallbladder and biliary tract carcinoma in China from 1990 to 2019: An analysis at the provincial level[J]. Cureus, 2023, 15( 8): e42796. DOI: 10.7759/cureus.42796.
[2]	WU L, TSILIMIGRAS DI, PAREDES AZ, et al. Trends in the incidence, treatment and outcomes of patients with intrahepatic cholangiocarcinoma in the USA: Facility type is associated with margin status, use of lymphadenectomy and overall survival[J]. World J Surg, 2019, 43( 7): 1777- 1787. DOI: 10.1007/s00268-019-04966-4.
[3]	MORIS D, PALTA M, KIM C, et al. Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians[J]. CA Cancer J Clin, 2023, 73( 2): 198- 222. DOI: 10.3322/caac.21759.
[4]	RAZUMILAVA N, GORES GJ. Cholangiocarcinoma[J]. Lancet, 2014, 383( 9935): 2168- 2179. DOI: 10.1016/S0140-6736(13)61903-0.
[5]	GRAVELY AK, VIBERT E, SAPISOCHIN G. Surgical treatment of intrahepatic cholangiocarcinoma[J]. J Hepatol, 2022, 77( 3): 865- 867. DOI: 10.1016/j.jhep.2022.01.004.
[6]	MAZZAFERRO V, GORGEN A, ROAYAIE S, et al. Liver resection and transplantation for intrahepatic cholangiocarcinoma[J]. J Hepatol, 2020, 72( 2): 364- 377. DOI: 10.1016/j.jhep.2019.11.020.
[7]	MAVROS MN, ECONOMOPOULOS KP, ALEXIOU VG, et al. Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: Systematic review and meta-analysis[J]. JAMA Surg, 2014, 149( 6): 565- 574. DOI: 10.1001/jamasurg.2013.5137.
[8]	TSILIMIGRAS DI, SAHARA K, WU L, et al. Very early recurrence after liver resection for intrahepatic cholangiocarcinoma: Considering alternative treatment approaches[J]. JAMA Surg, 2020, 155( 9): 823- 831. DOI: 10.1001/jamasurg.2020.1973.
[9]	SPOLVERATO G, KIM Y, ALEXANDRESCU S, et al. Management and outcomes of patients with recurrent intrahepatic cholangiocarcinoma following previous curative-intent surgical resection[J]. Ann Surg Oncol, 2016, 23( 1): 235- 243. DOI: 10.1245/s10434-015-4642-9.
[10]	VOGEL A, BRIDGEWATER J, EDELINE J, et al. Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up[J]. Ann Oncol, 2023, 34( 2): 127- 140. DOI: 10.1016/j.annonc.2022.10.506.
[11]	BENSON AB, D’ANGELICA MI, ABRAMS T, et al. NCCN Guidelines^® Insights: Biliary tract cancers, version 2.2023[J]. J Natl Compr Canc Netw, 2023, 21( 7): 694- 704. DOI: 10.6004/jnccn.2023.0035.
[12]	BARTSCH F, EBERHARD J, RÜCKERT F, et al. Repeated resection for recurrent intrahepatic cholangiocarcinoma: A retrospective German multicentre study[J]. Liver Int, 2021, 41( 1): 180- 191. DOI: 10.1111/liv.14682.
[13]	RAMOUZ A, ALI-HASAN-AL-SAEGH S, SHAFIEI S, et al. Repeat liver resection for recurrent intrahepatic cholangiocarcinoma: Meta-analysis[J]. Br J Surg, 2022, 109( 7): 580- 587. DOI: 10.1093/bjs/znac075.
[14]	SI AF, LI J, XING XL, et al. Effectiveness of repeat hepatic resection for patients with recurrent intrahepatic cholangiocarcinoma: Factors associated with long-term outcomes[J]. Surgery, 2017, 161( 4): 897- 908. DOI: 10.1016/j.surg.2016.10.024.
[15]	YAMASHITA YI, SHIRABE K, BEPPU T, et al. Surgical management of recurrent intrahepatic cholangiocarcinoma: Predictors, adjuvant chemotherapy, and surgical therapy for recurrence: A multi-institutional study by the Kyushu study group of liver surgery[J]. Ann Gastroenterol Surg, 2017, 1( 2): 136- 142. DOI: 10.1002/ags3.12018.
[16]	PAWLIK TM. ASO author reflections: Understanding recurrence patterns and time courses of intrahepatic cholangiocarcinoma after surgery helps in postoperative surveillance and treatment[J]. Ann Surg Oncol, 2019, 26( 8): 2558- 2559. DOI: 10.1245/s10434-019-07437-1.
[17]	BAGANTE F, MERATH K, SQUIRES MH, et al. The limitations of standard clinicopathologic features to accurately risk-stratify prognosis after resection of intrahepatic cholangiocarcinoma[J]. J Gastrointest Surg, 2018, 22( 3): 477- 485. DOI: 10.1007/s11605-018-3682-4.
[18]	ZHANG XF, BEAL EW, BAGANTE F, et al. Early versus late recurrence of intrahepatic cholangiocarcinoma after resection with curative intent[J]. Br J Surg, 2018, 105( 7): 848- 856. DOI: 10.1002/bjs.10676.
[19]	KOJIMA T, UMEDA Y, FUJI T, et al. Efficacy of surgical management for recurrent intrahepatic cholangiocarcinoma: A multi-institutional study by the Okayama study group of HBP surgery[J]. PLoS One, 2020, 15( 9): e0238392. DOI: 10.1371/journal.pone.0238392.
[20]	BEKKI Y, VON AHRENS D, TAKAHASHI H, et al. Recurrent intrahepatic cholangiocarcinoma-review[J]. Front Oncol, 2021, 11: 776863. DOI: 10.3389/fonc.2021.776863.
[21]	CHAN KM, TSAI CY, YEH CN, et al. Characterization of intrahepatic cholangiocarcinoma after curative resection: Outcome, prognostic factor, and recurrence[J]. BMC Gastroenterol, 2018, 18( 1): 180. DOI: 10.1186/s12876-018-0912-x.
[22]	WANG C, PANG S, SI-MA H, et al. Specific risk factors contributing to early and late recurrences of intrahepatic cholangiocarcinoma after curative resection[J]. World J Surg Oncol, 2019, 17( 1): 2. DOI: 10.1186/s12957-018-1540-1.
[23]	LIN QZ, LIU HZ, ZHOU WP, et al. Effect of postoperative adjuvant chemotherapy on prognosis of patients with intrahepatic cholangiocarcinoma: A multicenter retrospective study[J]. Chin J Surg, 2023, 61( 4): 305- 312. DOI: 10.3760/cma.j.cn112139-20230106-00010. 林起柱, 刘红枝, 周伟平, 等. 术后辅助化疗对肝内胆管癌预后影响的多中心回顾性研究[J]. 中华外科杂志, 2023, 61( 4): 305- 312. DOI: 10.3760/cma.j.cn112139-20230106-00010.
[24]	ASAOKA T, KOBAYASHI S, HANAKI T, et al. Clinical significance of preoperative CA19-9 and lymph node metastasis in intrahepatic cholangiocarcinoma[J]. Surg Today, 2020, 50( 10): 1176- 1186. DOI: 10.1007/s00595-020-01992-x.
[25]	HU LS, WEISS M, POPESCU I, et al. Impact of microvascular invasion on clinical outcomes after curative-intent resection for intrahepatic cholangiocarcinoma[J]. J Surg Oncol, 2019, 119( 1): 21- 29. DOI: 10.1002/jso.25305.
[26]	ZHANG SJ, HU P, WANG N, et al. Thermal ablation versus repeated hepatic resection for recurrent intrahepatic cholangiocarcinoma[J]. Ann Surg Oncol, 2013, 20( 11): 3596- 3602. DOI: 10.1245/s10434-013-3035-1.
[27]	SOUCHE R, ADDEO P, OUSSOULTZOGLOU E, et al. First and repeat liver resection for primary and recurrent intrahepatic cholangiocarcinoma[J]. Am J Surg, 2016, 212( 2): 221- 229. DOI: 10.1016/j.amjsurg.2015.07.016.
[28]	LANGELLA S, RUSSOLILLO N, OSSOLA P, et al. Recurrence after curative resection for intrahepatic cholangiocarcinoma: How to predict the chance of repeat hepatectomy?[J]. J Clin Med, 2021, 10( 13): 2820. DOI: 10.3390/jcm10132820.
[29]	YOH T, HATANO E, SEO S, et al. Long-term survival of recurrent intrahepatic cholangiocarcinoma: The impact and selection of repeat surgery[J]. World J Surg, 2018, 42( 6): 1848- 1856. DOI: 10.1007/s00268-017-4387-7.
[30]	SAKATA J, NOMURA T, AONO T, et al. Oncological outcomes of surgery for recurrent biliary tract cancer: Who are the best candidates?[J]. HPB(Oxford), 2021, 23( 9): 1371- 1382. DOI: 10.1016/j.hpb.2021.01.007.
[31]	KITANO Y, YAMASHITA YI, NAKAGAWA S, et al. Effectiveness of surgery for recurrent cholangiocarcinoma: A single center experience and brief literature review[J]. Am J Surg, 2020, 219( 1): 175- 180. DOI: 10.1016/j.amjsurg.2019.02.015.
[32]	YOH T, HATANO E, NISHIO T, et al. Significant improvement in outcomes of patients with intrahepatic cholangiocarcinoma after surgery[J]. World J Surg, 2016, 40( 9): 2229- 2236. DOI: 10.1007/s00268-016-3583-1.
[33]	SUN W, DING XY, CHEN JL, et al. Clinical effect and safety of radiofrequency ablation combined with systemic chemotherapy in treatment of unresectable or postoperative recurrent intrahepatic cholangiocellular carcinoma[J]. J Clin Hepatol, 2018, 34( 8): 1717- 1722. DOI: 10.3969/j.issn.1001-5256.2018.08.025. 孙巍, 丁晓燕, 陈京龙, 等. 射频消融联合系统化疗治疗不可切除或术后复发肝内胆管癌的效果和安全性[J]. 临床肝胆病杂志, 2018, 34( 8): 1717- 1722. DOI: 10.3969/j.issn.1001-5256.2018.08.025.
[34]	LIN JZ, YANG X, LONG JY, et al. Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma[J]. Hepatobiliary Surg Nutr, 2020, 9( 4): 414- 424. DOI: 10.21037/hbsn-20-338.
[35]	GOYAL L, MERIC-BERNSTAM F, HOLLEBECQUE A, et al. Updated results of the FOENIX-CCA2 trial: Efficacy and safety of futibatinib in intrahepatic cholangiocarcinoma(iCCA) harboring FGFR2 fusions/rearrangements[J]. J Clin Oncol, 2022, 40( 16_suppl): 4009. DOI: 10.1200/jco.2022.40.16_suppl.4009.
[36]	SUI MH, LI Y, WANG HG, et al. Two cases of intrahepatic cholangiocellular carcinoma with high insertion-deletion ratios that achieved a complete response following chemotherapy combined with PD-1 blockade[J]. J Immunother Cancer, 2019, 7( 1): 125. DOI: 10.1186/s40425-019-0596-y.
[37]	YU W, HU CX, SHUI YJ, et al. Failure patterns after curative resection for intrahepatic cholangiocarcinoma: Possible implications for postoperative radiotherapy[J]. BMC Cancer, 2019, 19( 1): 1108. DOI: 10.1186/s12885-019-6328-3.
[38]	JUNG DH, KIM MS, CHO CK, et al. Outcomes of stereotactic body radiotherapy for unresectable primary or recurrent cholangiocarcinoma[J]. Radiat Oncol J, 2014, 32( 3): 163- 169. DOI: 10.3857/roj.2014.32.3.163.
[39]	SMART AC, GOYAL L, HORICK N, et al. Hypofractionated radiation therapy for unresectable/locally recurrent intrahepatic cholangiocarcinoma[J]. Ann Surg Oncol, 2020, 27( 4): 1122- 1129. DOI: 10.1245/s10434-019-08142-9.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (107) PDF downloads(27)

Advances in treatment decision-making for extrahepatic recurrence of intrahepatic cholangiocarcinoma

DOI: 10.12449/JCH241204

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Advances in treatment decision-making for extrahepatic recurrence of intrahepatic cholangiocarcinoma

DOI: 10.12449/JCH241204

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content