The relationship between nonalcoholic fatty liver disease and insulin resistance

Objective o explore the relationship between nonalcoholic fatty liver disease (NAFLD) and insulin resistance.Methods A total of 102 liver disease patients (52 NAFLD and 50 non NAFLD) were included in the study.BMI, WHR, TC, TG, CRP, HDL-C, LDL-C, ALT, Cr, FBG, FINS and HOMA-IR were compared between the two groups were analyzed using logistic regression.Results In NAFLD group, the level of BMI (26.7±2.3 vs 22.4±2.5, P<0.01) , WHR (0.94±0.06 vs 0.83±0.05, P<0.01) , TG (2.4±0.6 vs 1.8±0.6, P<0.01) , ALT (37.3±8.3 vs 28.1±7.2, P<0.05) , FBG (6.2±1.4 vs 5.2±0.7, P<0.01) , FINS (23.6±13.6 vs 8.6±3.5, P<0.01) , HOMA-IR (6.7±4.7 vs 2.0±1.6, P<0.01) were higher than the non NAFLD group.In the logistic regression analysis BMI (P<0.01) , WHR (P<0.01) , TG (P<0.01) , ALT (P<0.05) and HOMA-IR (P<0.01) were independent factors.Conclusion BMI, WHR, TG, ALT and HOMA-IR were independent factors of NAFLD.