肝硬化患者肿瘤坏死因子水平变化与胰岛素抵抗的关系

To investigate the changes of tumor necrosis factor-α (TNF-α) with liver cirrhosis and the relationship between TNF-α and insulin resistance (IR) , 23 liver cirrhosis (groupA) ; 21 health without liver cirrhosis (groupB) were selected to compare fasting blood-glucose (FBG) , fasting blood-insulin (FINS) and serum TNF-α by oxidase method, RIA and ELISA, Insulin sensitivity index (ISI) was also calculated. Analysis of variance revealed that FINS, TNF-α were significantly higher while ISI lover in group A than those in group B. Correlation analysis showed that TNF-α was negatively correlated to ISI, and positively associated with TNF-α and FINS. The study indicates that significantly hight level of TNF-α and IR play an important role in the liver cirrhosis and glucose metabolic disorder.