Safety and effectiveness of pioglitazone in the treatment of non-alcoholic fatty liver disease

Xiang Yang; Ye JiaRun; Li XinPing

Issue 6

Jun. 2007

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Article Navigation > Journal of Clinical Hepatology > 2007 > 23(6): 434-435

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吡格列酮对非酒精性脂肪肝的疗效观察

Published Date: 2007-06-20

Abstract

Abstract

Objective To find out a safe and effective treatment of non-alcoholic fatty liver disease (NAFLD) ;Methods 43 cases of NAFLD were randomized divided into tow group;pioglitazone group (n=22) and control group (n=21) , ALT, GGT, TG, HOMA-IR, BMI were compared between the two group.Results At the end of the 3rd month, the parameters were all improved, but have no statistical difference. (P>0.05) ;At the end of the 6th months, ALT, GGT, TG, HOMA-IR and effectiveness in pioglitazone group were much better than that in the control;the differences were significant (P<0.05) .Conclusion Pioglitazone is safe and effective in the treatment of NAFLD.
- fatty liver,
- non-alcoholic,
- insulin resistance

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[1]丁效蕙, 赵景民.非酒精性脂肪性肝炎的发病机制及治疗的研究进展[J].世界华人消化杂志, 2005, 13∶371-375.

[2]Marchesini G, Brizi M, Biachi G, et al.Nonalcoholic fatty liver dis-ease:a feature of the metabolic syndrome[J].Diabetes, 2001, 50 (8) ∶1844-1850.

[3]Yoon D, Lee SH, Park HS, et al.Hypoadiponectinemia and insulin-resistance are associated with nonalcoholic fatty liver disease[J].Ko-rean Med Sci, 2005, 20∶421-426.

[4]中华医学会.肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪肝病诊断标准[J].中华肝脏病杂志, 2003, 1∶71.

[5]Day CP.Non-alcoholic fatty liver disease:current concepts andmanagement strategies[J].Clin Med, 2006, 6∶19-25.

[6]范建高.非酒精性脂肪肝的临床流行病学研究[J].中华消化杂志, 2002, 22∶106-107.

[7]Donati G, Stagni B, Piscaglia F, et al.Increased prevalence of fattyliver in arteria hypertensive with normal liver enzymes:role of insulinresistance[J].Gut, 2004, 53 (7) ∶923-924.

[8]Day CP, James OF.Steatohepatitis:a tale of two“hits”?[J].Gas-troenterology, 1998, 114∶842-845.

[9]张冬梅, 张桂英.改善胰岛素抵抗药物治疗大鼠非酒精性脂肪肝病的实验研究[J].中华医学杂志, 2006, 18∶1279-1283.

[10]王俊宏, 宋基中.罗格列酮在糖调节受损合并非酒精性脂肪肝病中的应用体会[J].中国医师杂志, 2006, 1∶122-123.

[11]蒙碧辉, 梁世坤.国产罗格列酮对实验性鼠肝脂肪变性的保护作用[J].中华消化杂志, 2003, 12∶718-722.

[12]Sanyal AJ, Mofrad PS, Contos MJ, et al.Apilot study of vitamin Eversus vitamin E and pioglitazone for the treatment of nonalcoholicsteatohepatitis[J].Clin Gastronenterol hepatol, 2004, 2∶1107-1015.

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沈阳化工大学材料科学与工程学院沈阳 110142

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吡格列酮对非酒精性脂肪肝的疗效观察

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吡格列酮对非酒精性脂肪肝的疗效观察

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