Comparative study of the effect of two different herbal compounds on CCl4 induced liver fibrosis in rats.

Zhao XinYan; Wang BaoEn; Wang TaiLing; Jia JiDong; Ma XueMei

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Jan. 2005

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Article Navigation > Journal of Clinical Hepatology > 2005 > 21(1): 21-24

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复方中药861与961抗肝纤维化疗效比较的实验研究

Published Date: 2005-01-20

Abstract

Abstract

To compare the anti-fibrotic effects of two Recipes of commonly used Chinese traditional herbal compounds.Sixty male Wistar rats were divided into four groups:control group (10 rats) , model group (20 rats) , group treated with compound 861 (15 rats) and group treated with compound 961 (15 rats) .Hepatic fibrosis was induced by carbon tetrachloride (CCl4) subcutaneous injection for 8 weeks.Herbal compounds 861 and 961 were administered by gastric gavage respectively.At the end of 8 weeks, the gene mRNA level of procollagen Ⅰ, procollagen Ⅲ and transforming growth factor beta one (TGF-β1) and tissue inhibitor of metalloproteinase one (TIMP-1) was examined by means of reverse transcription polymerase chain reaction (RT-PCR) .Histopathology of each group was assessed with HE, Masson and Sirus red staining.Compound 861 and 961 could decrease all mRNA level: procollagen Ⅰ, procollagen Ⅲ mRNA level, TGF-β1 and TIMP-mRNA level (P<0.01) .Compound 861 and Compound 961 could significantly suppress the fibrotic proliferation by pathological assays.It concluded that Compound 861 has the similar antifibotic effect with Compocmd 961.
- carbon tetrachloride,
- liver fibrosis,
- herbal compounds,
- transforming growth factor beta one (TGF-β1) ,
- tissue inhibitor of metalloproteinase one (TIMP-1)

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沈阳化工大学材料科学与工程学院沈阳 110142

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复方中药861与961抗肝纤维化疗效比较的实验研究

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复方中药861与961抗肝纤维化疗效比较的实验研究

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