转化生长因子β1对慢乙肝细胞免疫功能的影响

We observed the relationship between serum transforming growth factor-β1 (TGF-β1) and T lymphocyte subsets to search its role in cellular immune function. Serum TGF-β1 was detected by ELISA, meanwhile T lymphocyte subsets were detected. 1.Serum TGF-β1 levels in CHB and LC were notable higher than that in NC (P<0.01) and increased successively in mild, moderate, severe degree of CHB and LC. 2. CD 3 +T cells, CD 4 +T cells, CD 4 +/CD 8 + in CHB and LC were notable lower than those in NC and CD 8 +T cells were notable higher than that in NC. There was significantly negative correlation between TGF-β1 and CD 4 +T cells, CD 4 +/CD 8 + and positive correlation between TGF-β1 and CD 8 + T cells. Serum TGF-β1 levels in creased significantly in CHB and LC, but cellular immune function decreases. TGF-β1 may restrain cellular immune, this may be one of the causes of hypofunction of cellular immune in CHB and LC.