中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 1
Jan.  2005

转化生长因子β1及其Ⅰ、Ⅱ型受体在肝细胞癌中的表达

Research funding:

 

  • Published Date: 2005-01-20
  • Immunohistochemical technique was used to detect the expression of TGFβ1、TGFβRⅠ and TGFβRⅡ in 36 cases HCC and 42 cases paratumorous liver tissue. There was no difference in the positive rates of TGFβ1 expressioin between HCC tissue (69.4%) and paratumorous liver tissue (81.0%) (P>0.05) . However, by the semi-quantiative analysis, the positive area percentage of TGFβ1 expression decreased in HCC tissue (17.23±11.78%) compared with that in paratumorous liver tissue (38.47±15.34%) (P<0.05) . The positive rate of TGFβRⅠ expression decreased significantly in HCC tissue (41.7%) compared with that in paratumorous liver tissue (73.8%) (P<0.01) . The positive rates of TGFβRⅡ expression decreased significantly in HCC tissue (42.7%) compared with that in paratumorous liver tissue (85.7%) (P<0.01) . Both HCC and paratumorous liver tissue can express high level of TGFβ1, but the positive area percentage of TGFβ1 expression in the former decrease significantly compared with that in the later, which implies the decrease of TGFβ1 expression may be involved in liver cells malignant transformation and uncontrolled growth. Decreasing expression of TGFβRⅠ and TGFβRⅡ in HCC may be the reasons for escaping the negative regulation of TGFβⅠ.

     

  • [1] LutgensE , gijbelsM , SmookM , etal.Transforminggrowthfactor- (beta) mediatesbalancebetweeninflammationandfibrosisduringplaqueprogression.Arteriosclerosis, ThrombosisandVascularBiology[J].Dallas, 2002, 22 (6) ∶975-78.
    [2]钱建民, 王学浩.肝癌患者转化生长因子β1及其受体的表达意义[J].中华实验外科杂志, 2000, 17 (6) ∶535-536.
    [3]刘超, 区庆嘉.TGF -β1抑制肝癌细胞株BEL -7402的增殖[J].肝胆外科杂志, 1999, 7 (3) ∶219-221.
    [4] RomieeuR , LacabanneV , KayibandaM , etal.Criticalstagesoftu morgrowthregulationtransgenicmiceharboringahepatocellularcar cinomarevealedbydistinctpatternsoftumornecrosisfactor-alphaandtransforminggrowthfactor-betamRNAproduction[J].InIm munol, 1997, 9∶1409-1412.
    [5]刘超, 陈双, 区庆嘉.转化生长因子β1及其Ⅱ型受体在肝细胞癌中的基因表达[J].中华外科杂志, 1999, 37 (12) ∶740-742.
    [6] BedossaP , PeltierE , TerrisB , etal.Transforminggrowthfactor-betal (TGF -β1) andTGF -β1receptorsinnormal, cirrhotic, andneoplastichumanlivers[J].Hepatology, 1995, 21∶760.
    [7] KehrlJH , WakefieldLM , KobertsAB , etal.TransforminggrowthfacotrβisanimportantimmunomodulatoryproteinforhumanB -lymphocytes[J].JImmunol, 1986, 137∶3855.
    [8] RobertsAB , SpornMB , AssoianPK , etal.Transforminggrowthfactortype-β:Rapidinductionoffibrosisandangiogenesisinvivoandstimulationcollagenformatoninvitro[J].ProNatlAcadSciUSA , 1986, 83∶4167.
    [9] WangJ, HanW , ZborowskaJL , etal.Reducedexpressionoftrans forminggrowthfactorβtypeⅠreceptorcontributestothemalignancyofhumancoloncarcinomacells[J].JBiolChem, 1996, 271∶17366-17371.
    [10] KimIY , AhnHJ, ZelherDJ, etal.Geneticchangintransforminggrowthfactorbeta (TGF -beta) receptortypeⅠgenecorrelateswithinsensitivitytoTGF -beta1inhumanprostatecancercells[J].CanRes, 1996, 56∶44.
    [11] InagakiM , MoustakasA , LinHY , etal.Growthinhibitionbytransforminggrowthfactorbeta (TGF -beta) typeIisrestoredinTGF -beta-resistanthepatomacellsafterexpressionofTGF -betareceptortypeⅡcDNA[J].ProcNatlAcadSci, 1993, 90 (11) ∶5359-5363.
    [12] KnausPI , LindemanD , DeCoteauJF , etal.AdominantinhibitorymutantofthetypeⅡtransforminggrowthfactorbetareceptorinthemalignantprogressionofacutaeousT -celllymphoma[J].MolCellBiol, 1996, 16 (7) ∶3480-3489.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2257) PDF downloads(731) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return