转化生长因子β1及其Ⅰ、Ⅱ型受体在肝细胞癌中的表达

Immunohistochemical technique was used to detect the expression of TGFβ1、TGFβRⅠ and TGFβRⅡ in 36 cases HCC and 42 cases paratumorous liver tissue. There was no difference in the positive rates of TGFβ1 expressioin between HCC tissue (69.4%) and paratumorous liver tissue (81.0%) (P>0.05) . However, by the semi-quantiative analysis, the positive area percentage of TGFβ1 expression decreased in HCC tissue (17.23±11.78%) compared with that in paratumorous liver tissue (38.47±15.34%) (P<0.05) . The positive rate of TGFβRⅠ expression decreased significantly in HCC tissue (41.7%) compared with that in paratumorous liver tissue (73.8%) (P<0.01) . The positive rates of TGFβRⅡ expression decreased significantly in HCC tissue (42.7%) compared with that in paratumorous liver tissue (85.7%) (P<0.01) . Both HCC and paratumorous liver tissue can express high level of TGFβ1, but the positive area percentage of TGFβ1 expression in the former decrease significantly compared with that in the later, which implies the decrease of TGFβ1 expression may be involved in liver cells malignant transformation and uncontrolled growth. Decreasing expression of TGFβRⅠ and TGFβRⅡ in HCC may be the reasons for escaping the negative regulation of TGFβⅠ.