慢乙肝病人尿中转化生长因子-β1水平测定的意义

To examine urine transforming growth factor-β 1 concentration so as to ascertain the significance in hepatic fibrosis. Urine TGF-β 1 concentration and the level of serum PCⅢ, ⅣC, HA and LN were detected by sandwich enzymelinked immunosorbent assay (ELISA) and radioimunoassay (RIA) from 15 patient with chronic active hepatitis B and 15 with cirrhosis.The levels of urine TGF-β 1/Cr and serum PCⅢ, ⅣC, HA, LN in patients with cirrhosis were higher than those of chronic active hepatitis and normal group.Between them existed a positive correlation P<0.05 or P<0.01) .And urine TGF-β 1/Cr also showed a positive relationship with globulin and indirect bilirubin (IBil) (P<0.05) , but a negative with albumin (P<0.05) .Higher urine TGF-β 1/Cr levels correlate with more severe hepatic fibrosis.So it may be used as a useful marker for hepatic fibrogenesis.