To investigate the effect on TGF β1 and the receptors of TGF β1 controlled by KANGXIANRUANJIAN and the effect on anti-fibrosis with the theory. As an animal experiment, a fibrosis model of rats with carbon tetrachloride and bovine serum albumin was made. The effect on anti-fibrosis was determined by pathologic cytology, immune histochemistry and image analysis. KANGXIANRUANJIAN could inhibit HSCs, TGF β1 and the receptors of TGF β1 in the fibrosis model of rats. KANGXIANRUANJIAN could affect in the fibrosis model of rats. The reason may be that the activity of HSCs is inhibited so that TGF β1 and the receptors of TGF β1 are decreased.
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