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Mar.  2002
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Article Navigation >  Journal of Clinical Hepatology  > 2002  >  18(3): 181-182

抗纤软坚冲剂对转化生长因子β1及其受体的影响

  • Published Date: 2002-03-20
    Abstract
  • To investigate the effect on TGF β1 and the receptors of TGF β1 controlled by KANGXIANRUANJIAN and the effect on anti-fibrosis with the theory. As an animal experiment, a fibrosis model of rats with carbon tetrachloride and bovine serum albumin was made. The effect on anti-fibrosis was determined by pathologic cytology, immune histochemistry and image analysis. KANGXIANRUANJIAN could inhibit HSCs, TGF β1 and the receptors of TGF β1 in the fibrosis model of rats. KANGXIANRUANJIAN could affect in the fibrosis model of rats. The reason may be that the activity of HSCs is inhibited so that TGF β1 and the receptors of TGF β1 are decreased.

     

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    • References(4)
  • [1] 苑淑芳, 张俊富, 崔丽安, 等抗纤软坚冲剂抗肝纤维化临床研究[J]中西医结合肝病杂志, 1999, 9 (4) ∶33-34
    [2] 张俊富, 苑淑芳, 崔丽安, 等抗纤软坚冲剂抗肝纤维化实验研究[J]上海中医药杂志, 2001, (待发表)
    [3]罗瑞红, 杨绍基转化生长因子β1与肝纤维化[J]国外医学内科学分册, 2000, 27 (8) ∶348-350
    [4]谭龙益, 王皓, 孔宪涛HBV基因组表达对TGFβ及其Ⅱ, Ⅲ型受体的转录调控[J]中华消化杂志, 1998, 18 (2) ∶125-126.
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